PDB entry 6jke

View 6jke on RCSB PDB site
Description: Discovery and the crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2.
Class: transcription
Keywords: BET family, BET inhibitor, Bromodomain Inhibitor, BRD2-BD1 inhibitor, Transcription
Deposited on 2019-02-28, released 2020-07-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-08, with a file datestamp of 2020-07-03.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jkea_
  • Chain 'B':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jkeb_
  • Chain 'C':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jkec_
  • Heterogens: BUX, SO4, DTT, GOL, DMS, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6jkeA (A:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn

    Sequence, based on observed residues (ATOM records): (download) 
    >6jkeA (A:)
vtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlenny
ywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6jkeB (B:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn

    Sequence, based on observed residues (ATOM records): (download) 
    >6jkeB (B:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6jkeC (C:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn

    Sequence, based on observed residues (ATOM records): (download) 
    >6jkeC (C:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq