PDB entry 6jke
View 6jke on RCSB PDB site
Description: Discovery and the crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2.
Class: transcription
Keywords: BET family, BET inhibitor, Bromodomain Inhibitor, BRD2-BD1 inhibitor, Transcription
Deposited on
2019-02-28, released
2020-07-01
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-07-08, with a file datestamp of
2020-07-03.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.49
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Bromodomain-containing protein 2
Species: Homo sapiens [TaxId:9606]
Gene: BRD2, KIAA9001, RING3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6jkea_ - Chain 'B':
Compound: Bromodomain-containing protein 2
Species: Homo sapiens [TaxId:9606]
Gene: BRD2, KIAA9001, RING3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6jkeb_ - Chain 'C':
Compound: Bromodomain-containing protein 2
Species: Homo sapiens [TaxId:9606]
Gene: BRD2, KIAA9001, RING3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6jkec_ - Heterogens: BUX, SO4, DTT, GOL, DMS, PGE, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6jkeA (A:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn
Sequence, based on observed residues (ATOM records): (download)
>6jkeA (A:)
vtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlenny
ywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6jkeB (B:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn
Sequence, based on observed residues (ATOM records): (download)
>6jkeB (B:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq
- Chain 'C':
Sequence, based on SEQRES records: (download)
>6jkeC (C:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn
Sequence, based on observed residues (ATOM records): (download)
>6jkeC (C:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq