PDB entry 6jk8

View 6jk8 on RCSB PDB site
Description: cryo-em structure of the full-length human igf-1r in complex with insulin
Deposited on 2019-02-27, released 2020-03-04
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-02.
Experiment type: EM
Resolution: 4.7 Å
R-factor: N/A
AEROSPACI score: 0.06 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: insulin-like growth factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: IGF1R
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6jk8A (A:)
mksgsgggsptslwgllflsaalslwptsgeicgpgidirndyqqlkrlenctviegylh
illiskaedyrsyrfpkltviteylllfrvagleslgdlfpnltvirgwklfynyalvif
emtnlkdiglynlrnitrgairieknadlcylstvdwslildavsnnyivgnkppkecgd
lcpgtmeekpmcekttinneynyrcwttnrcqkmcpstcgkractennecchpeclgscs
apdndtacvacrhyyyagvcvpacppntyrfegwrcvdrdfcanilsaessdsegfvihd
gecmqecpsgfirngsqsmycipcegpcpkvceeekktktidsvtsaqmlqgctifkgnl
linirrgnniaselenfmglievvtgyvkirhshalvslsflknlrlilgeeqlegnysf
yvldnqnlqqlwdwdhrnltikagkmyfafnpklcvseiyrmeevtgtkgrqskgdintr
nngerascesdvlhftstttsknriiitwhryrppdyrdlisftvyykeapfknvteydg
qdacgsnswnmvdvdlppnkdvepgillhglkpwtqyavyvkavtltmvendhirgakse
ilyirtnasvpsipldvlsasnsssqlivkwnppslpngnlsyyivrwqrqpqdgylyrh
nycskdkipirkyadgtidieevtenpktevcggekgpccacpkteaekqaekeeaeyrk
vfenflhnsifvprperkrrdvmqvanttmssrsrnttaadtynitdpeeleteypffes
rvdnkertvisnlrpftlyridihscnheaeklgcsasnfvfartmpaegaddipgpvtw
eprpensiflkwpepenpnglilmyeikygsqvedqrecvsrqeyrkyggaklnrlnpgn
ytariqatslsgngswtdpvffyvqaktgyenfihliialpvavllivgglvimlyvfhr
krnnsrlgngvlyasvnpeyfsaadvyvpdewevarekitmsrelgqgsfgmvyegvakg
vvkdepetrvaiktvneaasmrerieflneasvmkefnchhvvrllgvvsqgqptlvime
lmtrgdlksylrslrpemennpvlappslskmiqmageiadgmaylnankfvhrdlaarn
cmvaedftvkigdfgmtrdiyetdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgv
vlweiatlaeqpyqglsneqvlrfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfl
eiissikeemepgfrevsfyyseenklpepeeldlepenmesvpldpsasssslplpdrh
sghkaengpgpgvlvlrasfderqpyahmnggrkneralplpqsstc

    Sequence, based on observed residues (ATOM records):
    >6jk8A (A:)
eicgpgidirndyqqlkrlenctviegylhillisrsyrfpkltviteylllfrvagles
lgdlfpnltvirgwklfynyalvifemtnlkdiglynlrnitrgairieknadlcylstv
dwslildavsnnyivgnkppkecgdlcpcekttinneynyrcwttnrcqkmcpstcacte
nnecchpeclgscsapdndtacvacrhyyyagvcvpacppntyrfegwrcvdrdfcanil
saessdsegfvihdgecmqecpsgfirngsqsmycipcegpcpkvceeekktktidsvts
aqmlqgctifkgnllinirrgnniaselenfmglievvtgyvkirhshalvslsflknlr
lilgeeqlegnysfyvldnqnlqqlwdwdhrnltikagkmyfafnpklcvseiyrmeevt
gtkgrqskgdintrnngerascesdvlhftstttsknriiitwhryrppdyrdlisftvy
ykeapfknvteydgqdacgsnswnmvdvdlppnkdvepgillhglkpwtqyavyvkavtl
tmvendhirgakseilyirtnasvpsipldvlsasnsssqlivkwnppslpngnlsyyiv
rwqrqpqdgylyrhnycskdkipirkyagpccacpkteaekqaekeeaeyrkvfenflhn
sifvprpypffesrvdnkertvisnlrpftlyridihscnheaeklgcsasnfvfartmp
aegaddipgpvtweprpensiflkwpepenpnglilmyeikygsqvedqrecvsrqeyrk
yggaklnrlnpgnytariqatslsgngswtdpvffyvqaktgy

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6jk8B (B:)
mksgsgggsptslwgllflsaalslwptsgeicgpgidirndyqqlkrlenctviegylh
illiskaedyrsyrfpkltviteylllfrvagleslgdlfpnltvirgwklfynyalvif
emtnlkdiglynlrnitrgairieknadlcylstvdwslildavsnnyivgnkppkecgd
lcpgtmeekpmcekttinneynyrcwttnrcqkmcpstcgkractennecchpeclgscs
apdndtacvacrhyyyagvcvpacppntyrfegwrcvdrdfcanilsaessdsegfvihd
gecmqecpsgfirngsqsmycipcegpcpkvceeekktktidsvtsaqmlqgctifkgnl
linirrgnniaselenfmglievvtgyvkirhshalvslsflknlrlilgeeqlegnysf
yvldnqnlqqlwdwdhrnltikagkmyfafnpklcvseiyrmeevtgtkgrqskgdintr
nngerascesdvlhftstttsknriiitwhryrppdyrdlisftvyykeapfknvteydg
qdacgsnswnmvdvdlppnkdvepgillhglkpwtqyavyvkavtltmvendhirgakse
ilyirtnasvpsipldvlsasnsssqlivkwnppslpngnlsyyivrwqrqpqdgylyrh
nycskdkipirkyadgtidieevtenpktevcggekgpccacpkteaekqaekeeaeyrk
vfenflhnsifvprperkrrdvmqvanttmssrsrnttaadtynitdpeeleteypffes
rvdnkertvisnlrpftlyridihscnheaeklgcsasnfvfartmpaegaddipgpvtw
eprpensiflkwpepenpnglilmyeikygsqvedqrecvsrqeyrkyggaklnrlnpgn
ytariqatslsgngswtdpvffyvqaktgyenfihliialpvavllivgglvimlyvfhr
krnnsrlgngvlyasvnpeyfsaadvyvpdewevarekitmsrelgqgsfgmvyegvakg
vvkdepetrvaiktvneaasmrerieflneasvmkefnchhvvrllgvvsqgqptlvime
lmtrgdlksylrslrpemennpvlappslskmiqmageiadgmaylnankfvhrdlaarn
cmvaedftvkigdfgmtrdiyetdyyrkggkgllpvrwmspeslkdgvfttysdvwsfgv
vlweiatlaeqpyqglsneqvlrfvmegglldkpdncpdmlfelmrmcwqynpkmrpsfl
eiissikeemepgfrevsfyyseenklpepeeldlepenmesvpldpsasssslplpdrh
sghkaengpgpgvlvlrasfderqpyahmnggrkneralplpqsstc

    Sequence, based on observed residues (ATOM records):
    >6jk8B (B:)
eicgpgidirndyqqlkrlenctviegylhilliskarsyrfpkltviteylllfrvagl
eslgdlfpnltvirgwklfynyalvifemtnlkdiglynlrnitrgairieknadlcyls
tvdwslildavsnnyivgnkppkecgdlcpgcekttinneynyrcwttnrcqkmcpstcg
kractennecchpeclgscsapdndtacvacrhyyyagvcvpacppntyrfegwrcvdrd
fcanilsaessdsegfvihdgecmqecpsgfirngsqsmycipcegpcpkvceeekktkt
idsvtsaqmlqgctifkgnllinirrgnniaselenfmglievvtgyvkirhshalvsls
flknlrlilgeeqlegnysfyvldnqnlqqlwdwdhrnltikagkmyfafnpklcvseiy
rmeevtgtkgrqskgdintrnngerascesdvlhftstttsknriiitwhryrppdyrdl
isftvyykeapfknvteynswnmvdvdlppnkdvepgillhglkpwtqyavyvkavtltm
vendhirgakseilyirtnasvpsipldvlsasnsssqlivkwnppslpngnlsyyivrw
qrqpqdgylyrhnycskdkipirkekqaekeeaeyrkvfenflhnsieypffesrvdnke
rtvisnlrpftlyridihscnheaeklgcsasnfvfartmpaegaddipgpvtweprpen
siflkwpepenpnglilmyeikygsqvedqrecvsrqeyrkyggaklnrlnpgnytariq
atslsgngswtdpvffyvqak

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6jk8C (C:)
malwmrllpllallalwgpdpaaafvnqhlcgshlvealylvcgergffytpktrreaed
lqvgqvelgggpgagslqplalegslqkrgiveqcctsicslyqlenycn

    Sequence, based on observed residues (ATOM records):
    >6jk8C (C:)
giveqcctsicslyqlenycn

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6jk8D (D:)
malwmrllpllallalwgpdpaaafvnqhlcgshlvealylvcgergffytpktrreaed
lqvgqvelgggpgagslqplalegslqkrgiveqcctsicslyqlenycn

    Sequence, based on observed residues (ATOM records):
    >6jk8D (D:)
nqhlcgshlvealylvcgergffyt