PDB entry 6jjp

View 6jjp on RCSB PDB site
Description: Crystal structure of Fab of a PD-1 monoclonal antibody MW11-h317 in complex with PD-1
Class: immune system
Keywords: PD-1, monoclonal antibody, cancer treatment, IMMUNE SYSTEM
Deposited on 2019-02-26, released 2019-10-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-02.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heavy chain of MW11-h317
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6JJP (0-219)
    Domains in SCOPe 2.08: d6jjpa_
  • Chain 'B':
    Compound: light chain of MW11-h317
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6JJP (0-213)
    Domains in SCOPe 2.08: d6jjpb1, d6jjpb2
  • Chain 'C':
    Compound: Programmed cell death protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Pdcd1, Pd1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jjpc_
  • Chain 'D':
    Compound: Heavy chain of MW11-h317
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6JJP (0-219)
    Domains in SCOPe 2.08: d6jjpd_
  • Chain 'E':
    Compound: light chain of MW11-h317
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6JJP (0-End)
    Domains in SCOPe 2.08: d6jjpe1, d6jjpe2
  • Chain 'F':
    Compound: Programmed cell death protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Pdcd1, Pd1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jjpf_
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6jjpA (A:)
evqlvesggglvkpggslrlscaasgftfssydmswvrqapgkglewvatisgggsytyy
pdsvkgrftisrdnaknslylqmnslraedtavyycaspdssgvaywgqgtlvtvssast
kgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6jjpB (B:)
divmtqsplslpvtpgepasitckasqdvetvvawylqkpgqsprlliywastrhtgvpd
rfsgsgsgtdftlkisrveaedvgvyycqqysrypwtfgqgtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6jjpC (C:)
pgwfldspdrpwnpptfspallvvtegdnatftcsfsntsesfvlnwyrmspsnqtdkla
afpedrsqpgqdcrfrvtqlpngrdfhmsvvrarrndsgtylcgaislapkaqikeslra
elrvterraevptahpspsprpagqfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6jjpC (C:)
rpwnpptfspallvvtegdnatftcsfsntsesfvlnwyrmspsnqtdklaafpedrsqp
gqdcrfrvtqlpngrdfhmsvvrarrndsgtylcgaislapkaqikeslraelrvte

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6jjpD (D:)
evqlvesggglvkpggslrlscaasgftfssydmswvrqapgkglewvatisgggsytyy
pdsvkgrftisrdnaknslylqmnslraedtavyycaspdssgvaywgqgtlvtvssast
kgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssgly
slssvvtvpssslgtqtyicnvnhkpsntkvdkkvepksc

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6jjpE (E:)
divmtqsplslpvtpgepasitckasqdvetvvawylqkpgqsprlliywastrhtgvpd
rfsgsgsgtdftlkisrveaedvgvyycqqysrypwtfgqgtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6jjpE (E:)
divmtqsplslpvtpgepasitckasqdvetvvawylqkpgqsprlliywastrhtgvpd
rfsgsgsgtdftlkisrveaedvgvyycqqysrypwtfgqgtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6jjpF (F:)
pgwfldspdrpwnpptfspallvvtegdnatftcsfsntsesfvlnwyrmspsnqtdkla
afpedrsqpgqdcrfrvtqlpngrdfhmsvvrarrndsgtylcgaislapkaqikeslra
elrvterraevptahpspsprpagqfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6jjpF (F:)
drpwnpptfspallvvtegdnatftcsfsntsesfvlnwyrmspsnqtdklaafpedrsq
pgqdcrfrvtqlpngrdfhmsvvrarrndsgtylcgaislapkaqikeslraelrvte