PDB entry 6jib

View 6jib on RCSB PDB site
Description: Human MTHFD2 in complex with DS44960156
Class: oxidoreductase
Keywords: inhibitor, folate, cofactor, dehydrogenase, oxidoreductase
Deposited on 2019-02-20, released 2019-06-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-10, with a file datestamp of 2019-07-05.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: MTHFD2, NMDMC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jiba1, d6jiba2
  • Chain 'B':
    Compound: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: MTHFD2, NMDMC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jibb1, d6jibb2
  • Heterogens: BQF, PO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6jibA (A:)
mgsshhhhhhssgenlyfqgeavvisgrklaqqikqevrqeveewvasgnkrphlsvilv
genpashsyvlnktraaavvginsetimkpasiseeellnlinklnnddnvdgllvqlpl
pehiderricnavspdkdvdgfhvinvgrmcldqysmlpatpwgvweiikrtgiptlgkn
vvvagrsknvgmpiamllhtdgaherpggdatvtishrytpkeqlkkhtiladivisaag
ipnlitadmikegaavidvginrvhdpvtakpklvgdvdfegvrqkagyitpvpggvgpm
tvamlmkntiiaakkvlrleere

    Sequence, based on observed residues (ATOM records): (download) 
    >6jibA (A:)
eavvisgrklaqqikqevrqeveewvasgnkrphlsvilvgenpashsyvlnktraaavv
ginsetimkpasiseeellnlinklnnddnvdgllvqlplpehiderricnavspdkdvd
gfhvinvgrmcldqysmlpatpwgvweiikrtgiptlgknvvvagrsknvgmpiamllht
dgaherpggdatvtishrytpkeqlkkhtiladivisaagipnlitadmikegaavidvg
inrvhkpklvgdvdfegvrqkagyitpvpggvgpmtvamlmkntiiaakkvlr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6jibB (B:)
mgsshhhhhhssgenlyfqgeavvisgrklaqqikqevrqeveewvasgnkrphlsvilv
genpashsyvlnktraaavvginsetimkpasiseeellnlinklnnddnvdgllvqlpl
pehiderricnavspdkdvdgfhvinvgrmcldqysmlpatpwgvweiikrtgiptlgkn
vvvagrsknvgmpiamllhtdgaherpggdatvtishrytpkeqlkkhtiladivisaag
ipnlitadmikegaavidvginrvhdpvtakpklvgdvdfegvrqkagyitpvpggvgpm
tvamlmkntiiaakkvlrleere

    Sequence, based on observed residues (ATOM records): (download) 
    >6jibB (B:)
eavvisgrklaqqikqevrqeveewvasgnkrphlsvilvgenpashsyvlnktraaavv
ginsetimkpasiseeellnlinklnnddnvdgllvqlplpehiderricnavspdkdvd
gfhvinvgrmcldqysmlpatpwgvweiikrtgiptlgknvvvagrsknvgmpiamllht
dgaherpggdatvtishrytpkeqlkkhtiladivisaagipnlitadmikegaavidvg
inrvhdkpklvgdvdfegvrqkagyitpvpggvgpmtvamlmkntiiaakkvlr