PDB entry 6jfb

View 6jfb on RCSB PDB site
Description: crystal structure of human pyruvate kinase m2 isoform
Deposited on 2019-02-08, released 2020-04-01
The last revision was dated 2020-04-01, with a file datestamp of 2020-03-27.
Experiment type: XRAY
Resolution: 2.12 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pyruvate kinase PKM Isoform M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Pyruvate kinase PKM Isoform M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Pyruvate kinase PKM Isoform M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Pyruvate kinase PKM Isoform M2
    Species: Homo sapiens [TaxId:9606]
    Gene: PKM, OIP3, PK2, PK3, PKM2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SER, PO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6jfbA (A:)
mgsshhhhhhssglvprgshmmskphseagtafiqtqqlhaamadtflehmcrldidspp
itarntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfa
sdpilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwl
dyknickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlp
avsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrr
fdeileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkpr
ptraegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelr
rlapitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqt
arqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgs
gftntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6jfbA (A:)
eagtafiqtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemik
sgmnvarlnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglikg
aevelkkgatlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkg
adflvtevenggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkas
dvhevrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvfla
qkmmigrcnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgd
ypleavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaii
vltksgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlr
vnfamnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6jfbB (B:)
mgsshhhhhhssglvprgshmmskphseagtafiqtqqlhaamadtflehmcrldidspp
itarntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfa
sdpilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwl
dyknickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlp
avsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrr
fdeileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkpr
ptraegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelr
rlapitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqt
arqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgs
gftntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6jfbB (B:)
seagtafiqtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemi
ksgmnvarlnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglik
evelkkgatlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqkga
dflvtevenggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasd
vhevrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaq
kmmigrcnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdy
pleavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiiv
ltksgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrv
nfamnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6jfbC (C:)
mgsshhhhhhssglvprgshmmskphseagtafiqtqqlhaamadtflehmcrldidspp
itarntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfa
sdpilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwl
dyknickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlp
avsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrr
fdeileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkpr
ptraegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelr
rlapitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqt
arqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgs
gftntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6jfbC (C:)
seagtafiqtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemi
ksgmnvarlnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtglik
taevelkkgatlkitldnaymekcdenilwldyknickvvevgskiyvddglislqvkqk
gadflvtevenggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirka
sdvhevrkvlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvfl
aqkmmigrcnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakg
dypleavrmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgai
ivltksgrsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdl
rvnfamnvgkargffkkgdvvivltgwrpgsgftntmrvvpvp

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6jfbD (D:)
mgsshhhhhhssglvprgshmmskphseagtafiqtqqlhaamadtflehmcrldidspp
itarntgiictigpasrsvetlkemiksgmnvarlnfshgtheyhaetiknvrtatesfa
sdpilyrpvavaldtkgpeirtglikgsgtaevelkkgatlkitldnaymekcdenilwl
dyknickvvevgskiyvddglislqvkqkgadflvtevenggslgskkgvnlpgaavdlp
avsekdiqdlkfgveqdvdmvfasfirkasdvhevrkvlgekgknikiiskienhegvrr
fdeileasdgimvargdlgieipaekvflaqkmmigrcnragkpvicatqmlesmikkpr
ptraegsdvanavldgadcimlsgetakgdypleavrmqhliareaeaaiyhlqlfeelr
rlapitsdpteatavgaveasfkccsgaiivltksgrsahqvaryrprapiiavtrnpqt
arqahlyrgifpvlckdpvqeawaedvdlrvnfamnvgkargffkkgdvvivltgwrpgs
gftntmrvvpvp

    Sequence, based on observed residues (ATOM records):
    >6jfbD (D:)
eagtafiqtqqlhaamadtflehmcrldidsppitarntgiictigpasrsvetlkemik
sgmnvarlnfshgtheyhaetiknvrtatesfasdpilyrpvavaldtkgpeirtgliae
velkkgatlkitldnkcdenilwldyknickvvevgskiyvddglislqvkqkgadflvt
evenggslgskkgvnlpgaavdlpavsekdiqdlkfgveqdvdmvfasfirkasdvhevr
kvlgekgknikiiskienhegvrrfdeileasdgimvargdlgieipaekvflaqkmmig
rcnragkpvicatqmlesmikkprptraegsdvanavldgadcimlsgetakgdypleav
rmqhliareaeaaiyhlqlfeelrrlapitsdpteatavgaveasfkccsgaiivltksg
rsahqvaryrprapiiavtrnpqtarqahlyrgifpvlckdpvqeawaedvdlrvnfamn
vgkargffkkgdvvivltgwrpgsgftntmrvvpvp