PDB entry 6je4

View 6je4 on RCSB PDB site
Description: crystal structure of nme1cas9-sgrna-dsdna dimer mediated by double protein inhibitor acriic3 monomers
Deposited on 2019-02-04, released 2019-11-06
The last revision was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 3.07 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: CRISPR-associated endonuclease Cas9
    Species: Neisseria meningitidis 8013 [TaxId:604162]
    Gene: cas9, NMV_1993
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9X1G5 (Start-1082)
      • engineered mutation (16)
      • engineered mutation (588)
  • Chain 'B':
    Compound: sgrna
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'C':
    Compound: target DNA strand
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'D':
    Compound: non-target DNA strand
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'E':
    Compound: CRISPR-associated endonuclease Cas9
    Species: Neisseria meningitidis 8013 [TaxId:604162]
    Gene: cas9, NMV_1993
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9X1G5 (Start-1082)
      • engineered mutation (16)
      • engineered mutation (588)
  • Chain 'F':
    Compound: sgrna
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'G':
    Compound: target DNA strand
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'H':
    Compound: non-target DNA strand
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'I':
    Compound: AcrIIC3
    Species: Neisseria meningitidis 8013 [TaxId:604162]
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: AcrIIC3
    Species: Neisseria meningitidis 8013 [TaxId:604162]
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: CRISPR-associated endonuclease Cas9
    Species: Neisseria meningitidis 8013 [TaxId:604162]
    Gene: cas9, NMV_1993
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9X1G5 (Start-1082)
      • engineered mutation (16)
      • engineered mutation (588)
  • Chain 'L':
    Compound: sgrna
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'M':
    Compound: target DNA strand
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'N':
    Compound: non-target DNA strand
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'O':
    Compound: CRISPR-associated endonuclease Cas9
    Species: Neisseria meningitidis 8013 [TaxId:604162]
    Gene: cas9, NMV_1993
    Database cross-references and differences (RAF-indexed):
    • Uniprot C9X1G5 (Start-1082)
      • engineered mutation (16)
      • engineered mutation (588)
  • Chain 'P':
    Compound: sgrna
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'Q':
    Compound: target DNA strand
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'R':
    Compound: non-target DNA strand
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'S':
    Compound: AcrIIC3
    Species: Neisseria meningitidis 8013 [TaxId:604162]
    Database cross-references and differences (RAF-indexed):
  • Chain 'T':
    Compound: AcrIIC3
    Species: Neisseria meningitidis 8013 [TaxId:604162]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: EDO, PEG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6je4A (A:)
    smaafkpnsinyilglaigiasvgwamveideeenpirlidlgvrvferaevpktgdsla
    marrlarsvrrltrrrahrllrtrrllkregvlqaanfdenglikslpntpwqlraaald
    rkltplewsavllhlikhrgylsqrknegetadkelgallkgvagnahalqtgdfrtpae
    lalnkfekesghirnqrsdyshtfsrkdlqaelillfekqkefgnphvsgglkegietll
    mtqrpalsgdavqkmlghctfepaepkaakntytaerfiwltklnnlrileqgserpltd
    teratlmdepyrkskltyaqarkllgledtaffkglrygkdnaeastlmemkayhaisra
    lekeglkdkksplnlspelqdeigtafslfktdeditgrlkdriqpeileallkhisfdk
    fvqislkalrrivplmeqgkrydeacaeiygdhygkknteekiylppipadeirnpvvlr
    alsqarkvingvvrrygsparihietarevgksfkdrkeiekrqeenrkdrekaaakfre
    yfpnfvgepkskdilklrlyeqqhgkclysgkeinlgrlnekgyveidaalpfsrtwdds
    fnnkvlvlgsenqnkgnqtpyeyfngkdnsrewqefkarvetsrfprskkqrillqkfde
    dgfkernlndtryvnrflcqfvadrmrltgkgkkrvfasngqitnllrgfwglrkvraen
    drhhaldavvvacstvamqqkitrfvrykemnafdgktidketgevlhqkthfpqpweff
    aqevmirvfgkpdgkpefeeadtleklrtllaeklssrpeavheyvtplfvsrapnrkms
    gqghmetvksakrldegvsvlrvpltqlklkdlekmvnrerepklyealkarleahkddp
    akafaepfykydkagnrtqqvkavrveqvqktgvwvrnhngiadnatmvrvdvfekgdky
    ylvpiyswqvakgilpdravvqgkdeedwqliddsfnfkfslhpndlvevitkkarmfgy
    faschrgtgninirihdldhkigkngilegigvktalsfqkyqidelgkeirpcrlkkrp
    pvr
    

    Sequence, based on observed residues (ATOM records):
    >6je4A (A:)
    sinyilglaigiasvgwamveideeenpirlidlgvrvferaevpktgdslamarrlars
    vrrltrrrahrllrtrrllkregvlqaanfdenglikslpntpwqlraaaldrkltplew
    savllhlikhrgylsqrknelgallkgvagnahalqtgdfrtpaelalnkfekesghirn
    qrsdyshtfsrkdlqaelillfekqkefgnphvsgglkegietllmtqrpalsgdavqkm
    lghctfepaepkaakntytaerfiwltklnnlrileqgserpltdteratlmdepyrksk
    ltyaqarkllgledtaffkglrygkdnaeastlmemkayhaisralekeglkdkksplnl
    spelqdeigtafslfktdeditgrlkdriqpeileallkhisfdkfvqislkalrrivpl
    meqgkrydeacaeiygdnteekiylppipadeirnpvvlralsqarkvingvvrrygspa
    rihietarevgksfkdrkeiekrqeenrkdrekaaakfreyfpnfvgepkskdilklrly
    eqqhgkclysgkeinlgrlnekgyveidaalpfsrtwddsfnnkvlvlgsenqnkgnqtp
    yeyfngkdnsrewqefkarvetsrfprskkqrillqkfdedgfkernlndtryvnrflcq
    fvadrmrltgkgkkrvfasngqitnllrgfwglrkvraendrhhaldavvvacstvamqq
    kitrfvrykemnahqkthfpqpweffaqevmirvfgkpdgkpefeeadtleklrtllaek
    lssrpeavheyvtplfvsrapnrkmsgqghmetvksakrldegvsvlrvpltqlklkdle
    kmvnrerepklyealkarleahkddpakafaepfykydkagnrtqqvkavrveqvqktgv
    wvrnhngiadnatmvrvdvfekgdkyylvpiyswqvakgilpdravvqgkdeedwqlidd
    sfnfkfslhpndlvevitkkarmfgyfaschrgtgninirihdldhkigkngilegigvk
    talsfqkyqidelgkeirpcrlkkrppvr
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6je4E (E:)
    smaafkpnsinyilglaigiasvgwamveideeenpirlidlgvrvferaevpktgdsla
    marrlarsvrrltrrrahrllrtrrllkregvlqaanfdenglikslpntpwqlraaald
    rkltplewsavllhlikhrgylsqrknegetadkelgallkgvagnahalqtgdfrtpae
    lalnkfekesghirnqrsdyshtfsrkdlqaelillfekqkefgnphvsgglkegietll
    mtqrpalsgdavqkmlghctfepaepkaakntytaerfiwltklnnlrileqgserpltd
    teratlmdepyrkskltyaqarkllgledtaffkglrygkdnaeastlmemkayhaisra
    lekeglkdkksplnlspelqdeigtafslfktdeditgrlkdriqpeileallkhisfdk
    fvqislkalrrivplmeqgkrydeacaeiygdhygkknteekiylppipadeirnpvvlr
    alsqarkvingvvrrygsparihietarevgksfkdrkeiekrqeenrkdrekaaakfre
    yfpnfvgepkskdilklrlyeqqhgkclysgkeinlgrlnekgyveidaalpfsrtwdds
    fnnkvlvlgsenqnkgnqtpyeyfngkdnsrewqefkarvetsrfprskkqrillqkfde
    dgfkernlndtryvnrflcqfvadrmrltgkgkkrvfasngqitnllrgfwglrkvraen
    drhhaldavvvacstvamqqkitrfvrykemnafdgktidketgevlhqkthfpqpweff
    aqevmirvfgkpdgkpefeeadtleklrtllaeklssrpeavheyvtplfvsrapnrkms
    gqghmetvksakrldegvsvlrvpltqlklkdlekmvnrerepklyealkarleahkddp
    akafaepfykydkagnrtqqvkavrveqvqktgvwvrnhngiadnatmvrvdvfekgdky
    ylvpiyswqvakgilpdravvqgkdeedwqliddsfnfkfslhpndlvevitkkarmfgy
    faschrgtgninirihdldhkigkngilegigvktalsfqkyqidelgkeirpcrlkkrp
    pvr
    

    Sequence, based on observed residues (ATOM records):
    >6je4E (E:)
    aafkpnsinyilglaigiasvgwamveideeenpirlidlgvrvferaevpktgdslama
    rrlarsvrrltrrrahrllrtrrllkregvlqaanfdenglikslpntpwqlraaaldrk
    ltplewsavllhlikhrgylsqrknelgallkgvagnahalqtgdfrtpaelalnkfeke
    sghirnqrsdyshtfsrkdlqaelillfekqkefgnphvsgglkegietllmtqrpalsg
    davqkmlghctfepaepkaakntytaerfiwltklnnlrileqgserpltdteratlmde
    pyrkskltyaqarkllgledtaffkglrygkdnaeastlmemkayhaisralekeglkdk
    ksplnlspelqdeigtafslfktdeditgrlkdriqpeileallkhisfdkfvqislkal
    rrivplmeqgkrydeacaeiygdnteekiylppipadeirnpvvlralsqarkvingvvr
    rygsparihietarevgksfkdrkeiekrqeenrkdrekaaakfreyfpnfvgepkskdi
    lklrlyeqqhgkclysgkeinlgrlnekgyveidaalpfsrtwddsfnnkvlvlgsenqn
    kgnqtpyeyfngkdnsrewqefkarvetsrfprskkqrillqkfdedgfkernlndtryv
    nrflcqfvadrmrltgkgkkrvfasngqitnllrgfwglrkvraendrhhaldavvvacs
    tvamqqkitrfvrykemnalhqkthfpqpweffaqevmirvfgkpdgkpefeeadtlekl
    rtllaeklssrpeavheyvtplfvsrapnrkmsgqghmetvksakrldegvsvlrvpltq
    lklkdlekmvnrerepklyealkarleahkddpakafaepfykydkagnrtqqvkavrve
    qvqktgvwvrnhngiadnatmvrvdvfekgdkyylvpiyswqvakgilpdravvqgkdee
    dwqliddsfnfkfslhpndlvevitkkarmfgyfaschrgtgninirihdldhkigkngi
    legigvktalsfqkyqidelgkeirpcrlkkrppvr
    

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records:
    >6je4I (I:)
    smfkraiiftsfngfekvsrtekrrlakiinarvsiideylrakdtnasldgqyraflfn
    despamteflaklkafaesctgisidaweieeseyvrlpverrdflaaangkeifki
    

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records:
    >6je4J (J:)
    smfkraiiftsfngfekvsrtekrrlakiinarvsiideylrakdtnasldgqyraflfn
    despamteflaklkafaesctgisidaweieeseyvrlpverrdflaaangkeifki
    

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6je4K (K:)
    smaafkpnsinyilglaigiasvgwamveideeenpirlidlgvrvferaevpktgdsla
    marrlarsvrrltrrrahrllrtrrllkregvlqaanfdenglikslpntpwqlraaald
    rkltplewsavllhlikhrgylsqrknegetadkelgallkgvagnahalqtgdfrtpae
    lalnkfekesghirnqrsdyshtfsrkdlqaelillfekqkefgnphvsgglkegietll
    mtqrpalsgdavqkmlghctfepaepkaakntytaerfiwltklnnlrileqgserpltd
    teratlmdepyrkskltyaqarkllgledtaffkglrygkdnaeastlmemkayhaisra
    lekeglkdkksplnlspelqdeigtafslfktdeditgrlkdriqpeileallkhisfdk
    fvqislkalrrivplmeqgkrydeacaeiygdhygkknteekiylppipadeirnpvvlr
    alsqarkvingvvrrygsparihietarevgksfkdrkeiekrqeenrkdrekaaakfre
    yfpnfvgepkskdilklrlyeqqhgkclysgkeinlgrlnekgyveidaalpfsrtwdds
    fnnkvlvlgsenqnkgnqtpyeyfngkdnsrewqefkarvetsrfprskkqrillqkfde
    dgfkernlndtryvnrflcqfvadrmrltgkgkkrvfasngqitnllrgfwglrkvraen
    drhhaldavvvacstvamqqkitrfvrykemnafdgktidketgevlhqkthfpqpweff
    aqevmirvfgkpdgkpefeeadtleklrtllaeklssrpeavheyvtplfvsrapnrkms
    gqghmetvksakrldegvsvlrvpltqlklkdlekmvnrerepklyealkarleahkddp
    akafaepfykydkagnrtqqvkavrveqvqktgvwvrnhngiadnatmvrvdvfekgdky
    ylvpiyswqvakgilpdravvqgkdeedwqliddsfnfkfslhpndlvevitkkarmfgy
    faschrgtgninirihdldhkigkngilegigvktalsfqkyqidelgkeirpcrlkkrp
    pvr
    

    Sequence, based on observed residues (ATOM records):
    >6je4K (K:)
    aafkpnsinyilglaigiasvgwamveideeenpirlidlgvrvferaevpktgdslama
    rrlarsvrrltrrrahrllrtrrllkregvlqaanfdenglikslpntpwqlraaaldrk
    ltplewsavllhlikhrgylsqrknetadkelgallkgvagnahalqtgdfrtpaelaln
    kfekesghirnqrsdyshtfsrkdlqaelillfekqkefgnphvsgglkegietllmtqr
    palsgdavqkmlghctfepaepkaakntytaerfiwltklnnlrileqgserpltdtera
    tlmdepyrkskltyaqarkllgledtaffkglrygkdnaeastlmemkayhaisraleke
    glkdkksplnlspelqdeigtafslfktdeditgrlkdriqpeileallkhisfdkfvqi
    slkalrrivplmeqgkrydeacaeiygdnteekiylppipadeirnpvvlralsqarkvi
    ngvvrrygsparihietarevgksfkdrkeiekrqeenrkdrekaaakfreyfpnfvgep
    kskdilklrlyeqqhgkclysgkeinlgrlnekgyveidaalpfsrtwddsfnnkvlvlg
    senqnkgnqtpyeyfngkdnsrewqefkarvetsrfprskkqrillqkfdedgfkernln
    dtryvnrflcqfvadrmrltgkgkkrvfasngqitnllrgfwglrkvraendrhhaldav
    vvacstvamqqkitrfvrykemnahqkthfpqpweffaqevmirvfgkpdgkpefeeadt
    leklrtllaeklssrpeavheyvtplfvsrapnrkmsgqghmetvksakrldegvsvlrv
    pltqlklkdlekmvnrerepklyealkarleahkddpakafaepfykydkagnrtqqvka
    vrveqvqktgvwvrnhngiadnatmvrvdvfekgdkyylvpiyswqvakgilpdravvqg
    kdeedwqliddsfnfkfslhpndlvevitkkarmfgyfaschrgtgninirihdldhkig
    kngilegigvktalsfqkyqidelgkeirpcrlkkrppvr
    

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    Sequence, based on SEQRES records:
    >6je4O (O:)
    smaafkpnsinyilglaigiasvgwamveideeenpirlidlgvrvferaevpktgdsla
    marrlarsvrrltrrrahrllrtrrllkregvlqaanfdenglikslpntpwqlraaald
    rkltplewsavllhlikhrgylsqrknegetadkelgallkgvagnahalqtgdfrtpae
    lalnkfekesghirnqrsdyshtfsrkdlqaelillfekqkefgnphvsgglkegietll
    mtqrpalsgdavqkmlghctfepaepkaakntytaerfiwltklnnlrileqgserpltd
    teratlmdepyrkskltyaqarkllgledtaffkglrygkdnaeastlmemkayhaisra
    lekeglkdkksplnlspelqdeigtafslfktdeditgrlkdriqpeileallkhisfdk
    fvqislkalrrivplmeqgkrydeacaeiygdhygkknteekiylppipadeirnpvvlr
    alsqarkvingvvrrygsparihietarevgksfkdrkeiekrqeenrkdrekaaakfre
    yfpnfvgepkskdilklrlyeqqhgkclysgkeinlgrlnekgyveidaalpfsrtwdds
    fnnkvlvlgsenqnkgnqtpyeyfngkdnsrewqefkarvetsrfprskkqrillqkfde
    dgfkernlndtryvnrflcqfvadrmrltgkgkkrvfasngqitnllrgfwglrkvraen
    drhhaldavvvacstvamqqkitrfvrykemnafdgktidketgevlhqkthfpqpweff
    aqevmirvfgkpdgkpefeeadtleklrtllaeklssrpeavheyvtplfvsrapnrkms
    gqghmetvksakrldegvsvlrvpltqlklkdlekmvnrerepklyealkarleahkddp
    akafaepfykydkagnrtqqvkavrveqvqktgvwvrnhngiadnatmvrvdvfekgdky
    ylvpiyswqvakgilpdravvqgkdeedwqliddsfnfkfslhpndlvevitkkarmfgy
    faschrgtgninirihdldhkigkngilegigvktalsfqkyqidelgkeirpcrlkkrp
    pvr
    

    Sequence, based on observed residues (ATOM records):
    >6je4O (O:)
    kpnsinyilglaigiasvgwamveideeenpirlidlgvrvferaevpktgdslamarrl
    arsvrrltrrrahrllrtrrllkregvlqaanfdenglikslpntpwqlraaaldrkltp
    lewsavllhlikhrgylsqrknelgallkgvagnahalqtgdfrtpaelalnkfekesgh
    irnqrsdyshtfsrkdlqaelillfekqkefgnphvsgglkegietllmtqrpalsgdav
    qkmlghctfepaepkaakntytaerfiwltklnnlrileqgserpltdteratlmdepyr
    kskltyaqarkllgledtaffkglrygkdnaeastlmemkayhaisralekeglkdkksp
    lnlspelqdeigtafslfktdeditgrlkdriqpeileallkhisfdkfvqislkalrri
    vplmeqgkrydeacaeiygdnteekiylppipadeirnpvvlralsqarkvingvvrryg
    sparihietarevgksfkdrkeiekrqeenrkdrekaaakfreyfpnfvgepkskdilkl
    rlyeqqhgkclysgkeinlgrlnekgyveidaalpfsrtwddsfnnkvlvlgsenqnkgn
    qtpyeyfngkdnsrewqefkarvetsrfprskkqrillqkfdedgfkernlndtryvnrf
    lcqfvadrmrltgkgkkrvfasngqitnllrgfwglrkvraendrhhaldavvvacstva
    mqqkitrfvrykemnathfpqpweffaqevmirvfgkpdgkpefeeadtleklrtllaek
    lssrpeavheyvtplfvsrapnrkmsgqghmetvksakrldegvsvlrvpltqlklkdle
    kmvnrerepklyealkarleahkddpakafaepfykydkagnrtqqvkavrveqvqktgv
    wvrnhngiadnatmvrvdvfekgdkyylvpiyswqvakgilpdravvqgkdeedwqlidd
    sfnfkfslhpndlvevitkkarmfgyfaschrgtgninirihdldhkigkngilegigvk
    talsfqkyqidelgkeirpcrlkkrppvr
    

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.

  • Chain 'R':
    No sequence available.

  • Chain 'S':
    Sequence; same for both SEQRES and ATOM records:
    >6je4S (S:)
    smfkraiiftsfngfekvsrtekrrlakiinarvsiideylrakdtnasldgqyraflfn
    despamteflaklkafaesctgisidaweieeseyvrlpverrdflaaangkeifki
    

  • Chain 'T':
    Sequence; same for both SEQRES and ATOM records:
    >6je4T (T:)
    smfkraiiftsfngfekvsrtekrrlakiinarvsiideylrakdtnasldgqyraflfn
    despamteflaklkafaesctgisidaweieeseyvrlpverrdflaaangkeifki