PDB entry 6jcy

View 6jcy on RCSB PDB site
Description: mycobacterium tuberculosis rna polymerase transcription initiation open complex with a chimeric ecf sigma factor sigh/e
Deposited on 2019-01-30, released 2019-05-29
The last revision was dated 2019-07-31, with a file datestamp of 2019-07-26.
Experiment type: XRAY
Resolution: 3.11 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA-directed RNA polymerase subunit alpha
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Gene: rpoA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: DNA-directed RNA polymerase subunit alpha
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Gene: rpoA
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: DNA-directed RNA polymerase subunit beta
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Gene: rpoB
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DNA-directed RNA polymerase subunit beta'
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Gene: rpoC
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: DNA-directed RNA polymerase subunit omega
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Gene: rpoZ
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: ECF RNA polymerase sigma factor SigH,ECF RNA polymerase sigma factor SigE,ECF RNA polymerase sigma factor SigH
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Gene: sigH
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: DNA (5'-d(*tp*tp*gp*tp*gp*gp*gp*ap*gp*cp*tp*gp*tp*cp*ap*cp*gp*gp*ap*tp*gp*cp*a)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'H':
    Compound: DNA (5'-d(*tp*gp*cp*ap*tp*cp*cp*gp*tp*gp*ap*gp*tp*cp*gp*ap*gp*gp*gp*t)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'I':
    Compound: RNA (5'-r(*cp*cp*up*cp*gp*a)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Heterogens: ZN, MG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6jcyA (A:)
mghhhhhhhhhhssghiegrhmlisqrptlsedvltdnrsqfvieplepgfgytlgnslr
rtllssipgaavtsiridgvlhefttvpgvkedvteiilnlkslvvsseedepvtmylrk
qgpgevtagdivppagvtvhnpgmhiatlndkgklevelvvergrgyvpavqnrasgaei
gripvdsiyspvlkvtykvdatrveqrtdfdklildvetknsisprdalasagktlvelf
glarelnveaegieigpspaeadhiasfalpiddldltvrsynclkregvhtvgelvart
esdlldirnfgqksidevkiklhqlglslkdsppsfdpsevagydvatgtwstegaydeq
dyaeteql

    Sequence, based on observed residues (ATOM records):
    >6jcyA (A:)
isqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvlhe
fttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhnpg
mhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvdatr
veqrtdfdklildvetknsisprdalasagktlvelfglar

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6jcyB (B:)
mghhhhhhhhhhssghiegrhmlisqrptlsedvltdnrsqfvieplepgfgytlgnslr
rtllssipgaavtsiridgvlhefttvpgvkedvteiilnlkslvvsseedepvtmylrk
qgpgevtagdivppagvtvhnpgmhiatlndkgklevelvvergrgyvpavqnrasgaei
gripvdsiyspvlkvtykvdatrveqrtdfdklildvetknsisprdalasagktlvelf
glarelnveaegieigpspaeadhiasfalpiddldltvrsynclkregvhtvgelvart
esdlldirnfgqksidevkiklhqlglslkdsppsfdpsevagydvatgtwstegaydeq
dyaeteql

    Sequence, based on observed residues (ATOM records):
    >6jcyB (B:)
mlisqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvl
hefttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhn
pgmhiatlndkgklevelvvergrgyvpavsgaeigripvdsiyspvlkvtykvdatrve
qrtdfdklildvetknsisprdalasagktlvelfglarelnveaegieig

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6jcyC (C:)
mvladsrqsktaaspspsrpqsssnnsvpgapnrvsfaklreplevpglldvqtdsfewl
igsprwresaaergdvnpvggleevlyelspiedfsgsmslsfsdprfddvkapvdeckd
kdmtyaaplfvtaefinnntgeiksqtvfmgdfpmmtekgtfiingtervvvsqlvrspg
vyfdetidkstdktlhsvkvipsrgawlefdvdkrdtvgvridrkrrqpvtvllkalgwt
seqiverfgfseimrstlekdntvgtdealldiyrklrpgepptkesaqtllenlffkek
rydlarvgrykvnkklglhvgepitsstlteedvvatieylvrlhegqttmtvpggvevp
vetddidhfgnrrlrtvgeliqnqirvgmsrmervvrermttqdveaitpqtlinirpvv
aaikeffgtsqlsqfmdqnnplsglthkrrlsalgpgglsreraglevrdvhpshygrmc
pietpegpnigligslsvyarvnpfgfietpyrkvvdgvvsdeivyltadeedrhvvaqa
nspidadgrfveprvlvrrkageveyvpssevdymdvsprqmvsvatamipflehddanr
almganmqrqavplvrseaplvgtgmelraaidagdvvvaeesgvieevsadyitvmhdn
gtrrtyrmrkfarsnhgtcanqcpivdagdrveagqviadgpctddgemalgknllvaim
pweghnyedaiilsnrlveedvltsihieeheidardtklgaeeitrdipnisdevladl
dergivrigaevrdgdilvgkvtpkgeteltpeerllraifgekarevrdtslkvphges
gkvigirvfsrededelpagvnelvrvyvaqkrkisdgdklagrhgnkgvigkilpvedm
pfladgtpvdiilnthgvprrmnigqilethlgwcahsgwkvdaakgvpdwaarlpdell
eaqpnaivstpvfdgaqeaelqgllsctlpnrdgdvlvdadgkamlfdgrsgepfpypvt
vgymyimklhhlvddkiharstgpysmitqqplggkaqfggqrfgemecwamqaygaayt
lqelltiksddtvgrvkvyeaivkgenipepgipesfkvllkelqslclnvevlssdgaa
ielregededleraaanlginlsrnesasvedla

    Sequence, based on observed residues (ATOM records):
    >6jcyC (C:)
rpqsssnnsvpgapnrvsfaklreplevpglldvqtdsfewligsprwresaaergdvnp
vggleevlyelspiedfsgsmslsfsdprfddvkapvdeckdkdmtyaaplfvtaefinn
ntgeiksqtvfmgdfpmmtekgtfiingtervvvsqlvrspgvyfdetidkstdktlhsv
kvipsrgawlefdvdkrdtvgvridrkrrqpvtvllkalgwtseqiverfgfseimrstl
ekdntvgtdealldiyrklrpgepptkesaqtllenlffkekrydlarvgrykvnkklgl
hvgepitsstlteedvvatieylvrlhegqttmtvpggvevpvetddidhfgnrrlrtvg
eliqnqirvgmsrmervvrermttqdveaitpqtlinirpvvaaikeffgtsqlsqfmdq
nnplsglthkrrlsalgpgglsreraglevrdvhpshygrmcpietpegpnigligslsv
yarvnpfgfietpyrkvvdgvvsdeivyltadeedrhvvaqanspidadgrfveprvlvr
rkageveyvpssevdymdvsprqmvsvatamipflehddanralmganmqrqavplvrse
aplvgtgmelraaidagdvvvaeesgvieevsadyitvmhdngtrrtyrmrkfarsnhgt
canqcpivdagdrveagqviadgpctddgemalgknllvaimpweghnyedaiilsnrlv
eedvltsihieeheidardtklgaeeitrdipnisdevladldergivrigaevrdgdil
vgkvtpkgeteltpeerllraifgekarevrdtslkvphgesgkvigirvfsrededelp
agvnelvrvyvaqkrkisdgdklagrhgnkgvigkilpvedmpfladgtpvdiilnthgv
prrmnigqilethlgwcahsgwkvdaakgvpdwaarlpdelleaqpnaivstpvfdgaqe
aelqgllsctlpnrdgdvlvdadgkamlfdgrsgepfpypvtvgymyimklhhlvddkih
arstgpysmitqqplggkaqfggqrfgemecwamqaygaaytlqelltiksddtvgrvkv
yeaivkgenipepgipesfkvllkelqslclnvevlssdgaaielregededleraaan

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6jcyD (D:)
mvldvnffdelriglataedirqwsygevkkpetinyrtlkpekdglfcekifgptrdwe
cycgkykrvrfkgiicercgvevtrakvrrermghielaapvthiwyfkgvpsrlgylld
lapkdlekiiyfaayvitsvdeemrhnelstleaemaverkavedqrdgelearaqklea
dlaeleaegakadarrkvrdggeremrqirdraqreldrlediwstftklapkqlivden
lyrelvdrygeyftgamgaesiqklienfdidaeaeslrdvirngkgqkklralkrlkvv
aafqqsgnspmgmvldavpvippelrpmvqldggrfatsdlndlyrrvinrnnrlkrlid
lgapeiivnnekrmlqesvdalfdngrrgrpvtgpgnrplkslsdllkgkqgrfrqnllg
krvdysgrsvivvgpqlklhqcglpklmalelfkpfvmkrlvdlnhaqniksakrmverq
rpqvwdvleeviaehpvllnraptlhrlgiqafepmlvegkaiqlhplvceafnadfdgd
qmavhlplsaeaqaearilmlssnnilspasgrplamprldmvtglyylttevpgdtgey
qpasgdhpetgvysspaeaimaadrgvlsvrakikvrltqlrppveieaelfghsgwqpg
dawmaettlgrvmfnellplgypfvnkqmhkkvqaaiindlaerypmivvaqtvdklkda
gfywatrsgvtvsmadvlvpprkkeildhyeeradkvekqfqrgalnhdernealveiwk
eatdevgqalrehypddnpiitivdsgatgnftqtrtlagmkglvtnpkgefiprpvkss
fregltvleyfinthgarkgladtalrtadsgyltrrlvdvsqdvivrehdcqtergivv
elaerapdgtlirdpyietsayartlgtdavdeagnvivergqdlgdpeidallaagitq
vkvrsvltcatstgvcatcygrsmatgklvdigeavgivaaqsigepgtqltmrtfhqgg
vgeditgglprvqelfearvprgkapiadvtgrvrledgerfykitivpddggeevvydk
iskrqrlrvfkhedgservlsdgdhvevgqqlmegsadphevlrvqgprevqihlvrevq
evyraqgvsihdkhievivrqmlrrvtiidsgsteflpgslidraefeaenrrvvaegge
paagrpvlmgitkaslatdswlsaasfqettrvltdaaincrsdklnglkenviigklip
agtginryrniavqpteearaaaytipsyedqyyspdfgaatgaavplddygysdyr

    Sequence, based on observed residues (ATOM records):
    >6jcyD (D:)
ldvnffdelriglataedirqwsygevkkpetinyrtlkpekdglfcekifgptrdwecy
cgkykrvrfkgiicercgvevtrakvrrermghielaapvthiwyfkgvpsrlgylldla
pkdlekiiyfaayvitsvdeemrhnelstleaemaverkavedqrdgelearaqkleadl
aeleaegakadarrkvrdggeremrqirdraqreldrlediwstftklapkqlivdenly
relvdrygeyftgamgaesiqklienfdidaeaeslrdvirngkgqkklralkrlkvvaa
fqqsgnspmgmvldavpvippelrpmvqldggrfatsdlndlyrrvinrnnrlkrlidlg
apeiivnnekrmlqesvdalfdngrrgrpvtgpgnrplkslsdllkgkqgrfrqnllgkr
vdysgrsvivvgpqlklhqcglpklmalelfkpfvmkrlvdlnhaqniksakrmverqrp
qvwdvleeviaehpvllnraptlhrlgiqafepmlvegkaiqlhplvceafnadfdgdqm
avhlplsaeaqaearilmlssnnilspasgrplamprldmvtglyylttevpgdtgeyqp
asgdhpetgvysspaeaimaadrgvlsvrakikvrltqlrppveieaelfghsgwqpgda
wmaettlgrvmfnellplgypfvnkqmhkkvqaaiindlaerypmivvaqtvdklkdagf
ywatrsgvtvsmadvlvpprkkeildhyeeradkvekqfqrgalnhdernealveiwkea
tdevgqalrehypddnpiitivdsgatgnftqtrtlagmkglvtnpkgefiprpvkssfr
egltvleyfinthgarkgladtalrtadsgyltrrlvdvsqdvivrehdcqtergivvel
aerapdgtlirdpyietsayartlgtdavdeagnvivergqdlgdpeidallaagitqvk
vrsvltcatstgvcatcygrsmatgklvdigeavgivaaqsigepgtqlttgglprvqel
fearvprgkapiadvtgrvrledgerfykitivpddggeevvydkiskrqrlrvfkhedg
servlsdgdhvevgqqlmegsadphevlrvqgprevqihlvrevqevyraqgvsihdkhi
evivrqmlrrvtiidsgsteflpgslidraefeaenrrvaagrpvlmgitkaslatdswl
saasfqettrvltdaaincrsdklnglkenviigklipagtginryrniavqpteearaa

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6jcyE (E:)
msisqsdaslaavpavdqfdpssgasggydtplgitnppidelldrvsskyalviyaakr
arqindyynqlgegileyvgplvepglqekplsialreihadllehtege

    Sequence, based on observed residues (ATOM records):
    >6jcyE (E:)
ggydtplgitnppidelldrvsskyalviyaakrarqindyynqlyvgplvepglqekpl
sialreihadllehte

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6jcyF (F:)
gamadidgvtgsaglqpgpseetdeeltarferdaiplldqlyggalrmtrnpadaedll
qetmvkayagfrsfrhgtnlkawlyriltntyinsyrrrarirmealpedydrvpadepn
peqiyhdarlgpdlqaalqalpeefrmavyyadvegfpykeiaeimdtpigtvmsrlhrg
rrqlrglladvardrgfargeqahegvss

    Sequence, based on observed residues (ATOM records):
    >6jcyF (F:)
deeltarferdaiplldqlyggalrmtrnpadaedllqetmvkayagfrsfrhgtnlkaw
lyriltntyinsyrrrarirmealpedydrvpadepnpeqiyhdarlgpdlqaalqalpe
efrmavyyadvegfpykeiaeimdtpigtvmsrlhrgrrqlrgl

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.