PDB entry 6jcu

View 6jcu on RCSB PDB site
Description: Crystal structure of an actin monomer in complex with a nucleator Cordon-Bleu WH2-motif peptide mutant. T22V, H11R
Class: structural protein/protein binding
Keywords: WH2, actin, sequestering, PROTEIN BINDING, STRUCTURAL PROTEIN-PROTEIN BINDING complex
Deposited on 2019-01-30, released 2020-02-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-05, with a file datestamp of 2020-01-31.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Actin, alpha skeletal muscle
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: ACTA1, ACTA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jcua1, d6jcua2
  • Chain 'B':
    Compound: Peptide from Protein cordon-bleu
    Species: Mus musculus [TaxId:10090]
    Gene: Cobl, Kiaa0633
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NBX1 (0-21)
      • engineered mutation (10)
      • engineered mutation (21)
  • Chain 'C':
    Compound: Actin, alpha skeletal muscle
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: ACTA1, ACTA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jcuc1, d6jcuc2
  • Chain 'D':
    Compound: Peptide from Protein cordon-bleu
    Species: Mus musculus [TaxId:10090]
    Gene: Cobl, Kiaa0633
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5NBX1 (0-21)
      • engineered mutation (10)
      • engineered mutation (21)
  • Heterogens: ATP, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6jcuA (A:)
    mcdedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdea
    qskrgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrek
    mtqimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrl
    dlagrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataasssslek
    syelpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannv
    msggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwit
    kqeydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6jcuA (A:)
    ttalvcdngsglvkagfagddapravfpsivgrprkdsyvgdeaqskrgiltlkypiehg
    iitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimfetfnvpamyv
    aiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrdltdylmkilt
    ergysfvttaereivrdikeklcyvaldfenemataassssleksyelpdgqvitigner
    frcpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggttmypgiadrmq
    keitalapstmkikiiapperkysvwiggsilaslstfqqmwitkqeydeagpsivhrkc
    f
    

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >6jcuC (C:)
    mcdedettalvcdngsglvkagfagddapravfpsivgrprhqgvmvgmgqkdsyvgdea
    qskrgiltlkypiehgiitnwddmekiwhhtfynelrvapeehptllteaplnpkanrek
    mtqimfetfnvpamyvaiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrl
    dlagrdltdylmkiltergysfvttaereivrdikeklcyvaldfenemataasssslek
    syelpdgqvitignerfrcpetlfqpsfigmesagihettynsimkcdidirkdlyannv
    msggttmypgiadrmqkeitalapstmkikiiapperkysvwiggsilaslstfqqmwit
    kqeydeagpsivhrkcf
    

    Sequence, based on observed residues (ATOM records): (download)
    >6jcuC (C:)
    ttalvcdngsglvkagfagddapravfpsivgrprkdsyvgdeaqskrgiltlkypiehg
    iitnwddmekiwhhtfynelrvapeehptllteaplnpkanrekmtqimfetfnvpamyv
    aiqavlslyasgrttgivldsgdgvthnvpiyegyalphaimrldlagrdltdylmkilt
    ergysfvttaereivrdikeklcyvaldfenemataassssleksyelpdgqvitigner
    frcpetlfqpsfigmesagihettynsimkcdidirkdlyannvmsggttmypgiadrmq
    keitalapstmkikiiapperkysvwiggsilaslstfqqmwitkqeydeagpsivhrkc
    

  • Chain 'D':
    No sequence available.