PDB entry 6j8h

View 6j8h on RCSB PDB site
Description: structure of human voltage-gated sodium channel nav1.7 in complex with auxiliary beta subunits, huwentoxin-iv and saxitoxin (y1755 down)
Deposited on 2019-01-19, released 2019-02-27
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-02.
Experiment type: EM
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sodium channel protein type 9 subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: SCN9A, NENA
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15858
      • variant (448)
  • Chain 'B':
    Compound: Sodium channel subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: SCN1B
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Sodium channel subunit beta-2
    Species: Homo sapiens [TaxId:9606]
    Gene: SCN2B, UNQ326/PRO386
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, 9SL

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6j8hA (A:)
    maswshpqfekgggarggsgggswshpqfekgfdykddddkgtmamlpppgpqsfvhftk
    qslalieqriaerkskepkeekkdddeeapkpssdleagkqlpfiygdippgmvsepled
    ldpyyadkktfivlnkgktifrfnatpalymlspfsplrrisikilvhslfsmlimctil
    tncifmtmnnppdwtknveytftgiytfeslvkilargfcvgeftflrdpwnwldfvviv
    fayltefvnlgnvsalrtfrvlralktisvipglktivgaliqsvkklsdvmiltvfcls
    vfaliglqlfmgnlkhkcfrnslennetlesimntleseedfrkyfyylegskdallcgf
    stdsgqcpegytcvkigrnpdygytsfdtfswaflalfrlmtqdywenlyqqtlraagkt
    ymiffvvviflgsfylinlilavvamaykeqnqanieeakqkelefqqmldrlkkeqeea
    eaiaaaaaeytsirrsrimglsesssetsklssksakerrnrrkkknqkklssgeekgda
    eklsksesedsirrksfhlgveghrrahekrlstpnqsplsirgslfsarrssrtslfsf
    kgrgrdigsetefaddehsifgdnesrrgslfvphrpqerrssnisqasrsppmlpvngk
    mhsavdcngvvslvdgrsalmlpngqllpeviidkatsddsgttnqihkkrrcssyllse
    dmlndpnlrqramsrasiltntveeleesrqkcppwwyrfahkfliwncspywikfkkci
    yfivmdpfvdlaiticivlntlfmamehhpmteefknvlaignlvftgifaaemvlklia
    mdpyeyfqvgwnifdslivtlslvelfladveglsvlrsfrllrvfklakswptlnmlik
    iignsvgalgnltlvlaiivfifavvgmqlfgksykecvckinddctlprwhmndffhsf
    livfrvlcgewietmwdcmevagqamclivymmvmvignlvvlnlflalllssfssdnlt
    aieedpdannlqiavtrikkginyvkqtlrefilkafskkpkisreirqaedlntkkeny
    isnhtlaemskghnflkekdkisgfgssvdkhlmedsdgqsfihnpsltvtvpiapgesd
    lenmnaeelssdsdseyskvrlnrssssecstvdnplpgegeeaeaepmnsdepeacftd
    gcvwrfsccqvniesgkgkiwwnirktcykivehswfesfivlmillssgalafediyie
    rkktikiileyadkiftyifilemllkwiaygyktyftnawcwldflivdvslvtlvant
    lgysdlgpikslrtlralrplralsrfegmrvvvnaligaipsimnvllvclifwlifsi
    mgvnlfagkfyecinttdgsrfpasqvpnrsecfalmnvsqnvrwknlkvnfdnvglgyl
    sllqvatfkgwtiimyaavdsvnvdkqpkyeyslymyiyfvvfiifgsfftlnlfigvii
    dnfnqqkkklggqdifmteeqkkyynamkklgskkpqkpiprpgnkiqgcifdlvtnqaf
    disimvliclnmvtmmvekegqsqhmtevlywinvvfiilftgecvlklislrhyyftvg
    wnifdfvvviisivgmfladlietyfvsptlfrvirlarigrilrlvkgakgirtllfal
    mmslpalfniglllflvmfiyaifgmsnfayvkkedgindmfnfetfgnsmiclfqitts
    agwdgllapilnskppdcdpkkvhpgssvegdcgnpsvgifyfvsyiiisflvvvnmyia
    vilenfsvateesteplseddfemfyevwekfdpdatqfiefsklsdfaaaldpplliak
    pnkvqliamdlpmvsgdrihcldilfaftkrvlgesgemdslrsqmeerfmsanpskvsy
    epitttlkrkqedvsatviqrayrryrlrqnvknissiyikdgdrdddllnkkdmafdnv
    nensspektdatssttsppsydsvtkpdkekyeqdrtekedkgkdskeskk
    

    Sequence, based on observed residues (ATOM records):
    >6j8hA (A:)
    plrrisikilvhslfsmlimctiltncifmtmnnppdwtknveytftgiytfeslvkila
    rgfcvgeftflrdpwnwldfvvivfayltefvnlgnvsalrtfrvlralktisvipglkt
    ivgaliqsvkklsdvmiltvfclsvfaliglqlfmgnlkhkcfrnslennetlesimntl
    eseedfrkyfyylegskdallcgfstdsgqcpegytcvkigrnpdygytsfdtfswafla
    lfrlmtqdywenlyqqtlraagktymiffvvviflgsfylinlilavvamaykeqnqani
    eeakcspywikfkkciyfivmdpfvdlaiticivlntlfmamehhpmteefknvlaignl
    vftgifaaemvlkliamdpyeyfqvgwnifdslivtlslvelfllsvlrsfrllrvfkla
    kswptlnmlikiignsvgalgnltlvlaiivfifavvgmqlfgksykecvckinddctlp
    rwhmndffhsflivfrvlcgewietmwdcmevagqamclivymmvmvignlvvlnlflal
    llssfsgkiwwnirktcykivehswfesfivlmillssgalafediyierkktikiiley
    adkiftyifilemllkwiaygyktyftnawcwldflivdvslvtlvantlgysdlgpiks
    lrtlralrplralsrfegmrvvvnaligaipsimnvllvclifwlifsimgvnlfagkfy
    ecinttdgsrfpasqvpnrsecfalmnvsqnvrwknlkvnfdnvglgylsllqvatfkgw
    tiimyaavdsvnvdkqpkyeyslymyiyfvvfiifgsfftlnlfigviidnfnqqkkklg
    gqdifmteeqkkyynamkklgskkpqkpiprpgnkiqgcifdlvtnqafdisimvlicln
    mvtmmvekegqsqhmtevlywinvvfiilftgecvlklislrhyyftvgwnifdfvvvii
    sivgmfladlietyfvsptlfrvirlarigrilrlvkgakgirtllfalmmslpalfnig
    lllflvmfiyaifgmsnfayvkkedgindmfnfetfgnsmiclfqittsagwdgllapil
    nskppdcdpkkvhpgssvegdcgnpsvgifyfvsyiiisflvvvnmyiavilenfsvate
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6j8hB (B:)
    mgrllalvvgaalvssacggcvevdseteavygmtfkilcisckrrsetnaetftewtfr
    qkgteefvkilryenevlqleederfegrvvwngsrgtkdlqdlsifitnvtynhsgdye
    chvyrllffenyehntsvvkkihievvdkanrdmasivseimmyvlivvltiwlvaemiy
    cykkiaaatetaaqenaseylaitseskenctgvqvae
    

    Sequence, based on observed residues (ATOM records):
    >6j8hB (B:)
    gcvevdseteavygmtfkilcisckrrsetnaetftewtfrqkgteefvkilryenevlq
    leederfegrvvwngsrgtkdlqdlsifitnvtynhsgdyechvyrllffenyehntsvv
    kkihievvdkanrdmasivseimmyvlivvltiwlvaemiycykkiaaateta
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6j8hC (C:)
    mhrdawlprpafsltglslffslvppgrsmevtvpatlnvlngsdarlpctfnscytvnh
    kqfslnwtyqecnncseemflqfrmkiinlklerfqdrvefsgnpskydvsvmlrnvqpe
    degiyncyimnppdrhrghgkihlqvlmeepperdstvavivgasvggflavvilvlmvv
    kcvrrkkeqklstddlkteeegktdgegnpddgak
    

    Sequence, based on observed residues (ATOM records):
    >6j8hC (C:)
    smevtvpatlnvlngsdarlpctfnscytvnhkqfslnwtyqecnncseemflqfrmkii
    nlklerfqdrvefsgnpskydvsvmlrnvqpedegiyncyimnppdrhrghgkihlqvlm