PDB entry 6j8e

View 6j8e on RCSB PDB site
Description: human nav1.2-beta2-kiiia ternary complex
Deposited on 2019-01-18, released 2019-02-27
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-02.
Experiment type: EM
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sodium channel protein type 2 subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: SCN2A, NAC2, SCN2A1, SCN2A2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Sodium channel subunit beta-2
    Species: Homo sapiens [TaxId:9606]
    Gene: SCN2B, UNQ326/PRO386
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Mu-conotoxin KIIIA
    Species: Conus kinoshitai, synthetic [TaxId:376876]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, 9Z9, NA

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6j8eA (A:)
    maswshpqfekgggarggsgggswshpqfekgfdykddddkgtmaqsvlvppgpdsfrff
    treslaaieqriaeekakrpkqerkdeddengpkpnsdleagkslpfiygdippemvsvp
    ledldpyyinkktfivlnkgkaisrfsatpalyiltpfnpirklaikilvhslfnmlimc
    tiltncvfmtmsnppdwtknveytftgiytfeslikilargfcledftflrdpwnwldft
    vitfayvtefvdlgnvsalrtfrvlralktisvipglktivgaliqsvkklsdvmiltvf
    clsvfaliglqlfmgnlrnkclqwppdnssfeinitsffnnsldgngttfnrtvsifnwd
    eyiedkshfyflegqndallcgnssdagqcpegyicvkagrnpnygytsfdtfswaflsl
    frlmtqdfwenlyqltlraagktymiffvlviflgsfylinlilavvamayeeqnqatle
    eaeqkeaefqqmleqlkkqqeeaqaaaaaasaesrdfsgaggigvfsesssvasklssks
    ekelknrrkkkkqkeqsgeeekndrvrksesedsirrkgfrfslegsrltyekrfssphq
    sllsirgslfsprrnsraslfsfrgrakdigsendfaddehstfedndsrrdslfvphrh
    gerrhsnvsqasrasrvlpilpmngkmhsavdcngvvslvggpstltsagqllpegttte
    teirkrrsssyhvsmdlledptsrqramsiasiltntmeeleesrqkcppcwykfanmcl
    iwdcckpwlkvkhlvnlvvmdpfvdlaiticivlntlfmamehypmteqfssvlsvgnlv
    ftgiftaemflkiiamdpyyyfqegwnifdgfivslslmelglanveglsvlrsfrllrv
    fklakswptlnmlikiignsvgalgnltlvlaiivfifavvgmqlfgksykecvckisnd
    celprwhmhdffhsflivfrvlcgewietmwdcmevagqtmcltvfmmvmvignlvvlnl
    flalllssfssdnlaatdddnemnnlqiavgrmqkgidfvkrkirefiqkafvrkqkald
    eikpledlnnkkdscisnhttieigkdlnylkdgngttsgigssvekyvvdesdymsfin
    npsltvtvpiavgesdfenlnteefssesdmeeskeklnatsssegstvdigapaegeqp
    evepeeslepeacftedcvrkfkccqisieegkgklwwnlrktcykivehnwfetfivfm
    illssgalafediyieqrktiktmleyadkvftyifilemllkwvaygfqvyftnawcwl
    dflivdvslvsltanalgyselgaikslrtlralrplralsrfegmrvvvnallgaipsi
    mnvllvclifwlifsimgvnlfagkfyhcinyttgemfdvsvvnnyseckaliesnqtar
    wknvkvnfdnvglgylsllqvatfkgwmdimyaavdsrnvelqpkyednlymylyfvifi
    ifgsfftlnlfigviidnfnqqkkkfggqdifmteeqkkyynamkklgskkpqkpiprpa
    nkfqgmvfdfvtkqvfdisimiliclnmvtmmvetddqsqemtnilywinlvfivlftge
    cvlklislryyyftigwnifdfvvvilsivgmflaeliekyfvsptlfrvirlarigril
    rlikgakgirtllfalmmslpalfniglllflvmfiyaifgmsnfayvkrevgiddmfnf
    etfgnsmiclfqittsagwdgllapilnsgppdcdpdkdhpgssvkgdcgnpsvgifffv
    syiiisflvvvnmyiavilenfsvateesaeplseddfemfyevwekfdpdatqfiefak
    lsdfadaldpplliakpnkvqliamdlpmvsgdrihcldilfaftkrvlgesgemdalri
    qmeerfmasnpskvsyepitttlkrkqeevsaiiiqrayrryllkqkvkkvssiykkdkg
    kecdgtpikedtlidklnenstpektdmtpsttsppsydsvtkpekekfekdksekedkg
    kdireskk
    

    Sequence, based on observed residues (ATOM records):
    >6j8eA (A:)
    pirklaikilvhslfnmlimctiltncvfmtmsnppdwtknveytftgiytfeslikila
    rgfcledftflrdpwnwldftvitfayvtefvdlgnvsalrtfrvlralktisvipglkt
    ivgaliqsvkklsdvmiltvfclsvfaliglqlfmgnlrnkclqwppdfnwdeyiedksh
    fyflegqndallcgnssdagqcpegyicvkagrnpnygytsfdtfswaflslfrlmtqdf
    wenlyqltlraagktymiffvlviflgsfylinlilavvamayeeqnqatleeaeqdcck
    pwlkvkhlvnlvvmdpfvdlaiticivlntlfmamehypmteqfssvlsvgnlvftgift
    aemflkiiamdpyyyfqegwnifdgfivslslmelglanveglsvlrsfrllrvfklaks
    wptlnmlikiignsvgalgnltlvlaiivfifavvgmqlfgksykecvckisndcelprw
    hmhdffhsflivfrvlcgewietmwdcmevagqtmcltvfmmvmvignlvvlnlflalll
    ssfsgklwwnlrktcykivehnwfetfivfmillssgalafediyieqrktiktmleyad
    kvftyifilemllkwvaygfqvyftnawcwldflivdvslvsltanalgyselgaikslr
    tlralrplralsrfegmrvvvnallgaipsimnvllvclifwlifsimgvnlfagkfyhc
    inyttgemfdvsvvnnyseckaliesnqtarwknvkvnfdnvglgylsllqvatfkgwmd
    imyaavdsrnvelqpkyednlymylyfvifiifgsfftlnlfigviidnfnqqkkkfggq
    difmteeqkkyynamkklgskkpqkpiprpankfqgmvfdfvtkqvfdisimiliclnmv
    tmmvetddqsqemtnilywinlvfivlftgecvlklislryyyftigwnifdfvvvilsi
    vgmflaeliekyfvsptlfrvirlarigrilrlikgakgirtllfalmmslpalfnigll
    lflvmfiyaifgmsnfayvkrevgiddmfnfetfgnsmiclfqittsagwdgllapilns
    gppdcdpdkdhpgssvkgdcgnpsvgifffvsyiiisflvvvnmyiavilenfsvatee
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6j8eC (C:)
    grsmevtvpatlnvlngsdarlpctfnscytvnhkqfslnwtyqecnncseemflqfrmk
    iinlklerfqdrvefsgnpskydvsvmlrnvqpedegiyncyimnppdrhrghgkihlqv
    lm
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >6j8eD (D:)
    ccncsskwcrdhsrcc