PDB entry 6j64

View 6j64 on RCSB PDB site
Description: Crystal structure of human HINT1 mutant complexing with AP4A
Class: hydrolase
Keywords: hydrolase, nucleotide binding, regulation of transcription, signal transduction
Deposited on 2019-01-14, released 2019-09-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-08, with a file datestamp of 2020-04-03.
Experiment type: XRAY
Resolution: 0.95 Å
R-factor: N/A
AEROSPACI score: 0.86 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histidine triad nucleotide-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HINT1, HINT, PKCI1, PRKCNH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49773 (Start-127)
      • engineered mutation (115)
    Domains in SCOPe 2.08: d6j64a_
  • Chain 'B':
    Compound: Histidine triad nucleotide-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HINT1, HINT, PKCI1, PRKCNH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49773 (Start-127)
      • engineered mutation (115)
    Domains in SCOPe 2.08: d6j64b_
  • Heterogens: TAU, B4P, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6j64A (A:)
slmadeiakaqvarpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkk
hisqisvaedddesllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlgg
rqmhwppg

    Sequence, based on observed residues (ATOM records): (download) 
    >6j64A (A:)
ggdtifgkiirkeipakiifeddrclafhdispqapthflvipkkhisqisvaedddesl
lghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlggrqmhwppg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6j64B (B:)
slmadeiakaqvarpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkk
hisqisvaedddesllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlgg
rqmhwppg

    Sequence, based on observed residues (ATOM records): (download) 
    >6j64B (B:)
rpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkkhisqisvaeddde
sllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlggrqmhwppg