PDB entry 6j5z

View 6j5z on RCSB PDB site
Description: Crystal structure of human HINT1 mutant complexing with AP3A
Class: hydrolase
Keywords: hydrolase, nucleotide binding, regulation of transcription, signal transduction
Deposited on 2019-01-12, released 2019-09-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-08, with a file datestamp of 2020-04-03.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: N/A
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histidine triad nucleotide-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HINT1, HINT, PKCI1, PRKCNH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49773 (Start-127)
      • engineered mutation (115)
    Domains in SCOPe 2.08: d6j5za_
  • Chain 'B':
    Compound: Histidine triad nucleotide-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HINT1, HINT, PKCI1, PRKCNH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49773 (Start-127)
      • engineered mutation (115)
    Domains in SCOPe 2.08: d6j5zb_
  • Chain 'C':
    Compound: Histidine triad nucleotide-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HINT1, HINT, PKCI1, PRKCNH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49773 (Start-127)
      • engineered mutation (115)
    Domains in SCOPe 2.08: d6j5zc_
  • Chain 'D':
    Compound: Histidine triad nucleotide-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: HINT1, HINT, PKCI1, PRKCNH1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P49773 (Start-127)
      • engineered mutation (115)
    Domains in SCOPe 2.08: d6j5zd_
  • Heterogens: ESA, ADN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6j5zA (A:)
slmadeiakaqvarpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkk
hisqisvaedddesllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlgg
rqmhwppg

    Sequence, based on observed residues (ATOM records): (download) 
    >6j5zA (A:)
rpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkkhisqisvaeddde
sllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlggrqmhwppg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6j5zB (B:)
slmadeiakaqvarpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkk
hisqisvaedddesllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlgg
rqmhwppg

    Sequence, based on observed residues (ATOM records): (download) 
    >6j5zB (B:)
gdtifgkiirkeipakiifeddrclafhdispqapthflvipkkhisqisvaedddesll
ghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlggrqmhwppg

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6j5zC (C:)
slmadeiakaqvarpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkk
hisqisvaedddesllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlgg
rqmhwppg

    Sequence, based on observed residues (ATOM records): (download) 
    >6j5zC (C:)
gdtifgkiirkeipakiifeddrclafhdispqapthflvipkkhisqisvaedddesll
ghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlggrqmhwppg

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6j5zD (D:)
slmadeiakaqvarpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkk
hisqisvaedddesllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlgg
rqmhwppg

    Sequence, based on observed residues (ATOM records): (download) 
    >6j5zD (D:)
rpggdtifgkiirkeipakiifeddrclafhdispqapthflvipkkhisqisvaeddde
sllghlmivgkkcaadlglnkgyrmvvnegsdggqsvyhvhlavlggrqmhwppg