PDB entry 6izq

View 6izq on RCSB PDB site
Description: PRMT4 bound with a bicyclic compound
Class: transferase
Keywords: Histone-arginine methyltransferase CARM1, TRANSFERASE
Deposited on 2018-12-20, released 2019-12-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: histone-arginine methyltransferase carm1
    Species: Homo sapiens [TaxId:9606]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6izqa_
  • Chain 'B':
    Compound: histone-arginine methyltransferase carm1
    Species: Homo sapiens [TaxId:9606]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6izqb_
  • Chain 'C':
    Compound: histone-arginine methyltransferase carm1
    Species: Homo sapiens [TaxId:9606]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6izqc_
  • Chain 'D':
    Compound: histone-arginine methyltransferase carm1
    Species: Homo sapiens [TaxId:9606]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6izqd_
  • Heterogens: XJ2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6izqA (A:)
savqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaq
agarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlf
nermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdls
alrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglv
hglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliank
rqsydisivaqvdqtgskssnlldlknpffryt

    Sequence, based on observed residues (ATOM records): (download) 
    >6izqA (A:)
savqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaq
agarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlf
nermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdls
alrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglv
hglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliank
rqsydisivaqvdqtgskssnlldlknpffry

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6izqB (B:)
savqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaq
agarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlf
nermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdls
alrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglv
hglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliank
rqsydisivaqvdqtgskssnlldlknpffryt

    Sequence, based on observed residues (ATOM records): (download) 
    >6izqB (B:)
vqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqag
arkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfne
rmlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsal
rgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvhg
lafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankrq
sydisivaqvdqtgskssnlldlknpffry

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6izqC (C:)
savqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaq
agarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlf
nermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdls
alrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglv
hglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliank
rqsydisivaqvdqtgskssnlldlknpffryt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6izqD (D:)
savqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaq
agarkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlf
nermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdls
alrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglv
hglafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliank
rqsydisivaqvdqtgskssnlldlknpffryt

    Sequence, based on observed residues (ATOM records): (download) 
    >6izqD (D:)
avqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqa
garkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfn
ermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsa
lrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvh
glafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankr
qsydisivaqvdqtgskssnlldlknpffr