PDB entry 6iy6

View 6iy6 on RCSB PDB site
Description: crystal structure of human cytosolic aspartyl-trna synthetase (drs) in complex with glutathion-s transferase (gst) domains from aminoacyl trna synthase complex-interacting multifunctional protein 2 (aimp2) and glutamyl-prolyl-trna synthetase (eprs)
Deposited on 2018-12-13, released 2019-09-11
The last revision was dated 2019-11-20, with a file datestamp of 2019-11-15.
Experiment type: XRAY
Resolution: 3.6 Å
R-factor: N/A
AEROSPACI score: 0.09 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aspartate--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: DARS, PIG40
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Aspartate--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: DARS, PIG40
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: AIMP2, JTV1, PRO0992
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: AIMP2, JTV1, PRO0992
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Bifunctional glutamate/proline--tRNA ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: EPRS, GLNS, PARS, QARS, QPRS, PIG32
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07814 (Start-156)
      • expression tag (157-158)
  • Chain 'F':
    Compound: Bifunctional glutamate/proline--tRNA ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: EPRS, GLNS, PARS, QARS, QPRS, PIG32
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07814 (Start-156)
      • expression tag (157-158)
  • Chain 'G':
    Compound: Aspartate--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: DARS, PIG40
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Aspartate--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: DARS, PIG40
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: AIMP2, JTV1, PRO0992
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: AIMP2, JTV1, PRO0992
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Bifunctional glutamate/proline--tRNA ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: EPRS, GLNS, PARS, QARS, QPRS, PIG32
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07814 (Start-156)
      • expression tag (157-158)
  • Chain 'L':
    Compound: Bifunctional glutamate/proline--tRNA ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: EPRS, GLNS, PARS, QARS, QPRS, PIG32
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07814 (Start-156)
      • expression tag (157-158)
  • Heterogens: ZN, PO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6iy6A (A:)
mgsshhhhhhssglvprgshmaedyakerygissmiqsqekpdrvlvrvrdltiqkadev
vwvrarvhtsrakgkqcflvlrqqqfnvqalvavgdhaskqmvkfaaninkesivdvegv
vrkvnqkigsctqqdvelhvqkiyvislaeprlplqlddavrpeaegeeegratvnqdtr
ldnrvidlrtstsqavfrlqsgichlfretlinkgfveiqtpkiisaasegganvftvsy
fknnaylaqspqlykqmcicadfekvfsigpvfraedsnthrhltefvgldiemafnyhy
hevmeeiadtmvqifkglqerfqteiqtvnkqfpcepfkfleptlrleycealamlreag
vemgdeddlstpnekllghlvkekydtdfyildkyplavrpfytmpdprnpkqsnsydmf
mrgeeilsgaqrihdpqllteralhhgidlekikayidsfrfgapphagggiglervtml
flglhnvrqtsmfprdpkrltp

    Sequence, based on observed residues (ATOM records):
    >6iy6A (A:)
dyakerygissmiqsqekpdrvlvrvrdltiqkadevvwvrarvhtsrakgkqcflvlrq
qqfnvqalvavgdhaskqmvkfaaninkesivdvegvvrkvnqkigsctqqdvelhvqki
yvislaeprlplrldnrvidlrtstsqavfrlqsgichlfretlinkgfveiqtpkiisa
qspqlykqmcicadfekvfsigpvfrrhltefvgldiemafnyhyhevmeeiadtmvqif
kglqerfqteiqtvnkqfpcepfkfleptlrleycealamlreagvemgdeddlstpnek
llghlvkekydtdfyildkyplavrpfytmpdprnpkqsnsydmfmrgeeilsgaqrihd
pqllteralhhgidlekikayidsfrfgapphagggiglervtmlflglhnvrqtsmfpr
d

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6iy6B (B:)
mgsshhhhhhssglvprgshmaedyakerygissmiqsqekpdrvlvrvrdltiqkadev
vwvrarvhtsrakgkqcflvlrqqqfnvqalvavgdhaskqmvkfaaninkesivdvegv
vrkvnqkigsctqqdvelhvqkiyvislaeprlplqlddavrpeaegeeegratvnqdtr
ldnrvidlrtstsqavfrlqsgichlfretlinkgfveiqtpkiisaasegganvftvsy
fknnaylaqspqlykqmcicadfekvfsigpvfraedsnthrhltefvgldiemafnyhy
hevmeeiadtmvqifkglqerfqteiqtvnkqfpcepfkfleptlrleycealamlreag
vemgdeddlstpnekllghlvkekydtdfyildkyplavrpfytmpdprnpkqsnsydmf
mrgeeilsgaqrihdpqllteralhhgidlekikayidsfrfgapphagggiglervtml
flglhnvrqtsmfprdpkrltp

    Sequence, based on observed residues (ATOM records):
    >6iy6B (B:)
dyakerygissmiqsqekpdrvlvrvrdltiqkadevvwvrarvhtsrakgkqcflvlrq
qqfnvqalvavgdhaskqmvkfaaninkesivdvegvvrkvnqkigsctqqdvelhvqki
yvislaeprlplrldnrvidlrtstsqavfrlqsgichlfretlinkgfveiqtpkiiaq
spqlykqmcicadfekvfsigpvfrhltefvgldiemafnyhyhevmeeiadtmvqifkg
lqerfqteiqtvnkqfpcepfkfleptlrleycealamlreagvemgdeddlstpnekll
ghlvkekydtdfyildkyplavrpfytmpdprnpkqsnsydmfmrgeeilsgaqrihdpq
llteralhhgidlekikayidsfrfgapphagggiglervtmlflglhnvrqtsmfprd

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6iy6C (C:)
mdygalkdivinanpaspplsllvlhrllcehfrvlstvhthssvksvpenllkcfgeqn
kkqprqdyqlgftliwknvpktqmkfsiqtmcpiegegniarflfslfgqkhnavnatli
dswvdiaifqlkegsskekaavfrsmnsalgkspwlagneltvadvvlwsvlqqiggcsv
tvpanvqrwmrscenlapfntalkllklehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6iy6C (C:)
galkdivinanpaspplsllvlhrllcehfrvlstvhthssvksvpenllkcfgdyqlgf
tliwknvpktqmkfsiqtmcpiegegniarflfslfgqkhnavnatlidswvdiaifqlk
egsskekaavfrsmnsalgkspwlagneltvadvvlwsvlqqisvtvpanvqrwmrscen
lapfntalkllk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6iy6D (D:)
mdygalkdivinanpaspplsllvlhrllcehfrvlstvhthssvksvpenllkcfgeqn
kkqprqdyqlgftliwknvpktqmkfsiqtmcpiegegniarflfslfgqkhnavnatli
dswvdiaifqlkegsskekaavfrsmnsalgkspwlagneltvadvvlwsvlqqiggcsv
tvpanvqrwmrscenlapfntalkllklehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6iy6D (D:)
galkdivinanpaspplsllvlhrllcehfrvlstvhthssvksvpenllkcfgdyqlgf
tliwknvpktqmkfsiqtmcpiegegniarflfslfgqkhnavnatlidswvdiaifqlk
egsskekaavfrsmnsalgkspwlagneltvadvvlwsvlqqisvtvpanvqrwmrscen
lapfntalkllk

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6iy6E (E:)
matlsltvnsgdpplgallavehvkddvsisveegkenilhvsenviftdvnsilrylar
vattaglygsnlmehteidhwlefsatklsscdsftstinelnhclslrtylvgnslsla
dlcvwatlkgnaawqeqlkqkkapvhvkrwfgfleaqlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6iy6E (E:)
tlsltvnsgdpplgallavehvkddvsisveegkenilhvsenviftdvnsilrylarva
ttaglygsnlmehteidhwlefsatklsscdsftstinelnhclslrtylvgnslsladl
cvwatlkgnaawqeqlkqkkapvhvkrwfgfleaqle

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6iy6F (F:)
matlsltvnsgdpplgallavehvkddvsisveegkenilhvsenviftdvnsilrylar
vattaglygsnlmehteidhwlefsatklsscdsftstinelnhclslrtylvgnslsla
dlcvwatlkgnaawqeqlkqkkapvhvkrwfgfleaqlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6iy6F (F:)
tlsltvnsgdpplgallavehvkddvsisveegkenilhvsenviftdvnsilrylarva
ttaglygsnlmehteidhwlefsatklsscdsftstinelnhclslrtylvgnslsladl
cvwatlkgnaawqeqlkqkkapvhvkrwfgfleaqle

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6iy6G (G:)
mgsshhhhhhssglvprgshmaedyakerygissmiqsqekpdrvlvrvrdltiqkadev
vwvrarvhtsrakgkqcflvlrqqqfnvqalvavgdhaskqmvkfaaninkesivdvegv
vrkvnqkigsctqqdvelhvqkiyvislaeprlplqlddavrpeaegeeegratvnqdtr
ldnrvidlrtstsqavfrlqsgichlfretlinkgfveiqtpkiisaasegganvftvsy
fknnaylaqspqlykqmcicadfekvfsigpvfraedsnthrhltefvgldiemafnyhy
hevmeeiadtmvqifkglqerfqteiqtvnkqfpcepfkfleptlrleycealamlreag
vemgdeddlstpnekllghlvkekydtdfyildkyplavrpfytmpdprnpkqsnsydmf
mrgeeilsgaqrihdpqllteralhhgidlekikayidsfrfgapphagggiglervtml
flglhnvrqtsmfprdpkrltp

    Sequence, based on observed residues (ATOM records):
    >6iy6G (G:)
dyakerygissmiqsqekpdrvlvrvrdltiqkadevvwvrarvhtsrakgkqcflvlrq
qqfnvqalvavgdhaskqmvkfaaninkesivdvegvvrkvnqkigsctqqdvelhvqki
yvislaeprlplrldnrvidlrtstsqavfrlqsgichlfretlinkgfveiqtpkiiss
pqlykqmcicadfekvfsigpvfhltefvgldiemafnyhyhevmeeiadtmvqifkglq
erfqteiqtvnkqfpcepfkfleptlrleycealamlreagvemgdeddlstpnekllgh
lvkekydtdfyildkyplavrpfytmpdprnpkqsnsydmfmrgeeilsgaqrihdpqll
teralhhgidlekikayidsfrfgapphagggiglervtmlflglhnvrqtsmfprd

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6iy6H (H:)
mgsshhhhhhssglvprgshmaedyakerygissmiqsqekpdrvlvrvrdltiqkadev
vwvrarvhtsrakgkqcflvlrqqqfnvqalvavgdhaskqmvkfaaninkesivdvegv
vrkvnqkigsctqqdvelhvqkiyvislaeprlplqlddavrpeaegeeegratvnqdtr
ldnrvidlrtstsqavfrlqsgichlfretlinkgfveiqtpkiisaasegganvftvsy
fknnaylaqspqlykqmcicadfekvfsigpvfraedsnthrhltefvgldiemafnyhy
hevmeeiadtmvqifkglqerfqteiqtvnkqfpcepfkfleptlrleycealamlreag
vemgdeddlstpnekllghlvkekydtdfyildkyplavrpfytmpdprnpkqsnsydmf
mrgeeilsgaqrihdpqllteralhhgidlekikayidsfrfgapphagggiglervtml
flglhnvrqtsmfprdpkrltp

    Sequence, based on observed residues (ATOM records):
    >6iy6H (H:)
dyakerygissmiqsqekpdrvlvrvrdltiqkadevvwvrarvhtsrakgkqcflvlrq
qqfnvqalvavgdhaskqmvkfaaninkesivdvegvvrkvnqkigsctqqdvelhvqki
yvislaeprlplrldnrvidlrtstsqavfrlqsgichlfretlinkgfveiqtpkiiss
pqlykqmcicadfekvfsigpvfhltefvgldiemafnyhyhevmeeiadtmvqifkglq
erfqteiqtvnkqfpcepfkfleptlrleycealamlreagvemgdeddlstpnekllgh
lvkekydtdfyildkyplavrpfytmpdprnpkqsnsydmfmrgeeilsgaqrihdpqll
teralhhgidlekikayidsfrfgapphagggiglervtmlflglhnvrqtsmfprd

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6iy6I (I:)
mdygalkdivinanpaspplsllvlhrllcehfrvlstvhthssvksvpenllkcfgeqn
kkqprqdyqlgftliwknvpktqmkfsiqtmcpiegegniarflfslfgqkhnavnatli
dswvdiaifqlkegsskekaavfrsmnsalgkspwlagneltvadvvlwsvlqqiggcsv
tvpanvqrwmrscenlapfntalkllklehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6iy6I (I:)
galkdivinanpaspplsllvlhrllcehfrvlstvhthssvksvpenllkcfgdyqlgf
tliwknvpktqmkfsiqtmcpiegegniarflfslfgqkhnavnatlidswvdiaifqlk
egsskekaavfrsmnsalgkspwlagneltvadvvlwsvlqqisvtvpanvqrwmrscen
lapfntalkllk

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6iy6J (J:)
mdygalkdivinanpaspplsllvlhrllcehfrvlstvhthssvksvpenllkcfgeqn
kkqprqdyqlgftliwknvpktqmkfsiqtmcpiegegniarflfslfgqkhnavnatli
dswvdiaifqlkegsskekaavfrsmnsalgkspwlagneltvadvvlwsvlqqiggcsv
tvpanvqrwmrscenlapfntalkllklehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6iy6J (J:)
galkdivinanpaspplsllvlhrllcehfrvlstvhthssvksvpenllkcfgedyqlg
ftliwknvpktqmkfsiqtmcpiegegniarflfslfgqkhnavnatlidswvdiaifql
kegsskekaavfrsmnsalgkspwlagneltvadvvlwsvlqqisvtvpanvqrwmrsce
nlapfntalkllk

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6iy6K (K:)
matlsltvnsgdpplgallavehvkddvsisveegkenilhvsenviftdvnsilrylar
vattaglygsnlmehteidhwlefsatklsscdsftstinelnhclslrtylvgnslsla
dlcvwatlkgnaawqeqlkqkkapvhvkrwfgfleaqlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6iy6K (K:)
tlsltvnsgdpplgallavehvkddvsisveegkenilhvsenviftdvnsilrylarva
ttaglygsnlmehteidhwlefsatklsscdsftstinelnhclslrtylvgnslsladl
cvwatlkgnaawqeqlkqkkapvhvkrwfgfleaqle

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6iy6L (L:)
matlsltvnsgdpplgallavehvkddvsisveegkenilhvsenviftdvnsilrylar
vattaglygsnlmehteidhwlefsatklsscdsftstinelnhclslrtylvgnslsla
dlcvwatlkgnaawqeqlkqkkapvhvkrwfgfleaqlehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6iy6L (L:)
tlsltvnsgdpplgallavehvkddvsisveegkenilhvsenviftdvnsilrylarva
ttaglygsnlmehteidhwlefsatklsscdsftstinelnhclslrtylvgnslsladl
cvwatlkgnaawqeqlkqkkapvhvkrwfgfleaqle