PDB entry 6iwl

View 6iwl on RCSB PDB site
Description: Crystal structure of enoyl-ACP-reductase (FabI) from Moraxella catarrhalis, in complex with NAD and estradiol
Class: oxidoreductase
Keywords: FabI, NADH, Estradiol, OXIDOREDUCTASE
Deposited on 2018-12-05, released 2019-12-11
Made obsolete by 7f44 on 2022-06-22

The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 2.34 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Enoyl-[acyl-carrier-protein] reductase [NADH]
    Species: Moraxella catarrhalis (strain BBH18) [TaxId:1236608]
    Gene: fabI, MCR_1078
    Database cross-references and differences (RAF-indexed):
    • Uniprot D5VCE0 (13-End)
      • variant (234)
    Domains in SCOPe 2.08: d6iwla_
  • Chain 'B':
    Compound: Enoyl-[acyl-carrier-protein] reductase [NADH]
    Species: Moraxella catarrhalis (strain BBH18) [TaxId:1236608]
    Gene: fabI, MCR_1078
    Database cross-references and differences (RAF-indexed):
    • Uniprot D5VCE0 (13-End)
      • variant (234)
    Domains in SCOPe 2.08: d6iwlb_
  • Chain 'C':
    Compound: Enoyl-[acyl-carrier-protein] reductase [NADH]
    Species: Moraxella catarrhalis (strain BBH18) [TaxId:1236608]
    Gene: fabI, MCR_1078
    Database cross-references and differences (RAF-indexed):
    • Uniprot D5VCE0 (13-End)
      • variant (234)
    Domains in SCOPe 2.08: d6iwlc_
  • Chain 'D':
    Compound: Enoyl-[acyl-carrier-protein] reductase [NADH]
    Species: Moraxella catarrhalis (strain BBH18) [TaxId:1236608]
    Gene: fabI, MCR_1078
    Database cross-references and differences (RAF-indexed):
    • Uniprot D5VCE0 (13-End)
      • variant (234)
    Domains in SCOPe 2.08: d6iwld_
  • Heterogens: EST, NAD, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6iwlA (A:)
hhhhhhenlyfqsmllkgqrfvvtgiasklsiawaiaeslhregaqliltypndkikkrv
dmaaeafdavaviecdvgsdesiqvcfdeiakhwgvgddkgidgivhaigfapadqldgd
ftqattregsqiahdissysfvalakagrellaarqgslltltyegsisvlpnynvmgma
kasleasvrylasslggegirvnaisagpirtlaasgiksfrrmldvsekiaplqrnvsq
eevgnaalfllspwasgitgeilfvdagfntvaisekimmmagdgeq

    Sequence, based on observed residues (ATOM records): (download) 
    >6iwlA (A:)
mllkgqrfvvtgiasklsiawaiaeslhregaqliltypndkikkrvdmaaeafdavavi
ecdvgsdesiqvcfdeiakhwgvgddkgidgivhaigfapadqldgdftqattregsqia
hdissysfvalakagrellaarqgslltltyegsisvlpnynvmgmakasleasvrylas
slggegirvnaisagpirtlaasgiksfrrmldvsekiaplqrnvsqeevgnaalfllsp
wasgitgeilfvdagfntvaisekimm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6iwlB (B:)
hhhhhhenlyfqsmllkgqrfvvtgiasklsiawaiaeslhregaqliltypndkikkrv
dmaaeafdavaviecdvgsdesiqvcfdeiakhwgvgddkgidgivhaigfapadqldgd
ftqattregsqiahdissysfvalakagrellaarqgslltltyegsisvlpnynvmgma
kasleasvrylasslggegirvnaisagpirtlaasgiksfrrmldvsekiaplqrnvsq
eevgnaalfllspwasgitgeilfvdagfntvaisekimmmagdgeq

    Sequence, based on observed residues (ATOM records): (download) 
    >6iwlB (B:)
mllkgqrfvvtgiasklsiawaiaeslhregaqliltypndkikkrvdmaaeafdavavi
ecdvgsdesiqvcfdeiakhwgvgddkgidgivhaigfapadqldgdftqattregsqia
hdissysfvalakagrellaarqgslltltyegsisvlpnynvmgmakasleasvrylas
slggegirvnaisagpirtlaasgiksfrrmldvsekiaplqrnvsqeevgnaalfllsp
wasgitgeilfvdagfntvaisekimm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6iwlC (C:)
hhhhhhenlyfqsmllkgqrfvvtgiasklsiawaiaeslhregaqliltypndkikkrv
dmaaeafdavaviecdvgsdesiqvcfdeiakhwgvgddkgidgivhaigfapadqldgd
ftqattregsqiahdissysfvalakagrellaarqgslltltyegsisvlpnynvmgma
kasleasvrylasslggegirvnaisagpirtlaasgiksfrrmldvsekiaplqrnvsq
eevgnaalfllspwasgitgeilfvdagfntvaisekimmmagdgeq

    Sequence, based on observed residues (ATOM records): (download) 
    >6iwlC (C:)
mllkgqrfvvtgiasklsiawaiaeslhregaqliltypndkikkrvdmaaeafdavavi
ecdvgsdesiqvcfdeiakhwgvgddkgidgivhaigfapadqldgdftqattregsqia
hdissysfvalakagrellaarqgslltltyegsisvlpnynvmgmakasleasvrylas
slggegirvnaisagpirtlaasgiksfrrmldvsekiaplqrnvsqeevgnaalfllsp
wasgitgeilfvdagfntvaisekimm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6iwlD (D:)
hhhhhhenlyfqsmllkgqrfvvtgiasklsiawaiaeslhregaqliltypndkikkrv
dmaaeafdavaviecdvgsdesiqvcfdeiakhwgvgddkgidgivhaigfapadqldgd
ftqattregsqiahdissysfvalakagrellaarqgslltltyegsisvlpnynvmgma
kasleasvrylasslggegirvnaisagpirtlaasgiksfrrmldvsekiaplqrnvsq
eevgnaalfllspwasgitgeilfvdagfntvaisekimmmagdgeq

    Sequence, based on observed residues (ATOM records): (download) 
    >6iwlD (D:)
mllkgqrfvvtgiasklsiawaiaeslhregaqliltypndkikkrvdmaaeafdavavi
ecdvgsdesiqvcfdeiakhwgvgddkgidgivhaigfapadqldgdftqattregsqia
hdissysfvalakagrellaarqgslltltyegsisvlpnynvmgmakasleasvrylas
slggegirvnaisagpirtlaasgiksfrrmldvsekiaplqrnvsqeevgnaalfllsp
wasgitgeilfvdagfntvaisekim