PDB entry 6iwi

View 6iwi on RCSB PDB site
Description: Crystal structure of PDE5A in complex with a novel inhibitor
Class: hydrolase
Keywords: PDE5A, Inhibitor, Complex structure, HYDROLASE
Deposited on 2018-12-05, released 2019-12-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-23, with a file datestamp of 2020-12-18.
Experiment type: XRAY
Resolution: 2.16 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE5A, PDE5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6iwia_
  • Heterogens: MG, ZN, B0C, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6iwiA (A:)
mgsshhhhhhssglvprgshmeetrelqslaaavvpsaqtlkitdfsfsdfelsdletal
ctirmftdlnlvqnfqmkhevlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagk
iqnkltdleilalliaalshdldhrgvnnsyiqrsehplaqlychsimehhhfdqclmil
nspgnqilsglsieeykttlkiikqailatdlalyikrrgeffelirknqfnledphqke
lflamlmtacdlsaitkpwpiqqriaelvateffdqgdrerkelnieptdlmnrekknki
psmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq

    Sequence, based on observed residues (ATOM records): (download) 
    >6iwiA (A:)
etrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevl
crwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdl
dhrgvnnhsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdlalyik
rrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvateffdqk
nkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq