PDB entry 6iwb

View 6iwb on RCSB PDB site
Description: crystal structure of a computationally designed protein (ld3) in complex with bcl-2
Deposited on 2018-12-05, released 2019-12-11
The last revision was dated 2020-06-24, with a file datestamp of 2020-06-19.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: apolipoprotein e
    Species: Homo sapiens [TaxId:9606]
    Gene: Apoe
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02649 (9-End)
      • see sequence details (20-21)
      • see sequence details (24)
      • see sequence details (27)
      • variant (98)
      • see sequence details (128-129)
      • see sequence details (131-132)
      • see sequence details (135-136)
      • see sequence details (139)
  • Chain 'B':
    Compound: Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: apolipoprotein e
    Species: Homo sapiens [TaxId:9606]
    Gene: Apoe
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02649 (9-End)
      • see sequence details (20-21)
      • see sequence details (24)
      • see sequence details (27)
      • variant (98)
      • see sequence details (128-129)
      • see sequence details (131-132)
      • see sequence details (135-136)
      • see sequence details (139)
  • Chain 'D':
    Compound: Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2
    Species: Homo sapiens [TaxId:9606]
    Gene: BCL2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6iwbA (A:)
mhhhhhhgsgqrwelalgrfleylswvstlseqvqeellssqvtqelralmdetmkelka
ykseleeqltpvaeetrarlskelqaaqarlgadmedvrgrlvqyrgevqamlgqsteel
rvrlashlialqlrligdafdlqkrlavyqagaaeq

    Sequence, based on observed residues (ATOM records):
    >6iwbA (A:)
gqrwelalgrfleylswvstlseqvqeellssqvtqelralmdetmkelkaykseleeql
tpvaeetrarlskelqaaqarlgadmedvrgrlvqyrgevqamlgqsteelrvrlashli
alqlrligdafdlqkrlavyqa

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6iwbB (B:)
mahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhltlrqag
ddfsrryrrdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmcves
vnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr

    Sequence, based on observed residues (ATOM records):
    >6iwbB (B:)
ydnreivmkyihyklsqrgyewdsevvhltlrqagddfsrryrrdfaemssqlhltpfta
rgrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhlh
twiqdnggwdafvelygps

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6iwbC (C:)
mhhhhhhgsgqrwelalgrfleylswvstlseqvqeellssqvtqelralmdetmkelka
ykseleeqltpvaeetrarlskelqaaqarlgadmedvrgrlvqyrgevqamlgqsteel
rvrlashlialqlrligdafdlqkrlavyqagaaeq

    Sequence, based on observed residues (ATOM records):
    >6iwbC (C:)
gqrwelalgrfleylswvstlseqvqeellssqvtqelralmdetmkelkaykseleeql
tpvaeetrarlskelqaaqarlgadmedvrgrlvqyrgevqamlgqsteelrvrlashli
alqlrligdafdlqkrlavyqag

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6iwbD (D:)
mahagrtgydnreivmkyihyklsqrgyewdagddveenrteapegtesevvhltlrqag
ddfsrryrrdfaemssqlhltpftargrfatvveelfrdgvnwgrivaffefggvmcves
vnremsplvdnialwmteylnrhlhtwiqdnggwdafvelygpsmr

    Sequence, based on observed residues (ATOM records):
    >6iwbD (D:)
ydnreivmkyihyklsqrgyewdsevvhltlrqagddfsrryrrdfaemssqlhltpfta
rgrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhlh
twiqdnggwdafvelygps