PDB entry 6iw7

View 6iw7 on RCSB PDB site
Description: structural insights into mycobacterium tuberculosis clpp1p2 inhibition by cediranib: implications for developing antimicrobial agents targeting clp protease
Deposited on 2018-12-04, released 2020-01-01
The last revision was dated 2020-04-29, with a file datestamp of 2020-04-24.
Experiment type: XRAY
Resolution: 2.69 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP-dependent Clp protease proteolytic subunit 2
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP2, MT2535
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: ATP-dependent clp protease proteolytic subunit 1
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP1, clpP, MT2536
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: ATP-dependent Clp protease proteolytic subunit 2
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP2, MT2535
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: ATP-dependent clp protease proteolytic subunit 1
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP1, clpP, MT2536
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: ATP-dependent Clp protease proteolytic subunit 2
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP2, MT2535
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: ATP-dependent Clp protease proteolytic subunit 2
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP2, MT2535
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: ATP-dependent clp protease proteolytic subunit 1
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP1, clpP, MT2536
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: ATP-dependent Clp protease proteolytic subunit 2
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP2, MT2535
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: ATP-dependent clp protease proteolytic subunit 1
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP1, clpP, MT2536
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: ATP-dependent Clp protease proteolytic subunit 2
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP2, MT2535
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: ATP-dependent clp protease proteolytic subunit 1
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP1, clpP, MT2536
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: ATP-dependent Clp protease proteolytic subunit 2
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP2, MT2535
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: ATP-dependent clp protease proteolytic subunit 1
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP1, clpP, MT2536
    Database cross-references and differences (RAF-indexed):
  • Chain 'N':
    Compound: ATP-dependent clp protease proteolytic subunit 1
    Species: Mycobacterium tuberculosis CDC1551 [TaxId:83331]
    Gene: clpP1, clpP, MT2536
    Database cross-references and differences (RAF-indexed):
  • Chain 'O':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'P':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'Q':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'R':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'T':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'U':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'V':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'W':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'X':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'Z':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'a':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'b':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'd':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Chain 'e':
    Compound: bez-leu-leu
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6IW7 (0-2)
  • Heterogens: AV3, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6iw7A (A:)
ryilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrdi
tmyinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarv
lihqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltae
eakdygiidtvleyrklsaqta

    Sequence, based on observed residues (ATOM records):
    >6iw7A (A:)
ilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrditm
yinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarvli
hqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltaeea
kdygiidtvleyrk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6iw7B (B:)
mrsnsqglsltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyins
pggsisagmaiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqpl
ggvtgsaadiaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfv
dhiitrahvngeaq

    Sequence, based on observed residues (ATOM records):
    >6iw7B (B:)
ltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyinspggsisagm
aiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqplggvtgsaad
iaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfvdhiitr

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6iw7C (C:)
ryilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrdi
tmyinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarv
lihqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltae
eakdygiidtvleyrklsaqta

    Sequence, based on observed residues (ATOM records):
    >6iw7C (C:)
ilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrditm
yinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarvli
hqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltaeea
kdygiidtvleyrkls

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6iw7D (D:)
mrsnsqglsltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyins
pggsisagmaiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqpl
ggvtgsaadiaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfv
dhiitrahvngeaq

    Sequence, based on observed residues (ATOM records):
    >6iw7D (D:)
tdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyinspggsisagma
iydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqplggvtgsaadi
aiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfvdhiit

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6iw7E (E:)
ryilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrdi
tmyinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarv
lihqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltae
eakdygiidtvleyrklsaqta

    Sequence, based on observed residues (ATOM records):
    >6iw7E (E:)
ilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrditm
yinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarvli
hqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltaeea
kdygiidtvleyr

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6iw7F (F:)
ryilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrdi
tmyinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarv
lihqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltae
eakdygiidtvleyrklsaqta

    Sequence, based on observed residues (ATOM records):
    >6iw7F (F:)
ilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrditm
yinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarvli
hqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltaeea
kdygiidtvleyrkls

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6iw7G (G:)
mrsnsqglsltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyins
pggsisagmaiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqpl
ggvtgsaadiaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfv
dhiitrahvngeaq

    Sequence, based on observed residues (ATOM records):
    >6iw7G (G:)
ltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyinspggsisagm
aiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqplggvtgsaad
iaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfvdhiit

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6iw7H (H:)
ryilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrdi
tmyinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarv
lihqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltae
eakdygiidtvleyrklsaqta

    Sequence, based on observed residues (ATOM records):
    >6iw7H (H:)
ilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrditm
yinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarvli
hqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltaeea
kdygiidtvleyrkls

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6iw7I (I:)
mrsnsqglsltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyins
pggsisagmaiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqpl
ggvtgsaadiaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfv
dhiitrahvngeaq

    Sequence, based on observed residues (ATOM records):
    >6iw7I (I:)
tdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyinspggsisagma
iydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqplggvtgsaadi
aiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfvdhiit

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6iw7J (J:)
ryilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrdi
tmyinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarv
lihqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltae
eakdygiidtvleyrklsaqta

    Sequence, based on observed residues (ATOM records):
    >6iw7J (J:)
yilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrdit
myinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarvl
ihqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltaee
akdygiidtvleyrk

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6iw7K (K:)
mrsnsqglsltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyins
pggsisagmaiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqpl
ggvtgsaadiaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfv
dhiitrahvngeaq

    Sequence, based on observed residues (ATOM records):
    >6iw7K (K:)
tdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyinspggsisagma
iydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqplggvtgsaadi
aiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfvdhiit

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6iw7L (L:)
ryilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrdi
tmyinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarv
lihqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltae
eakdygiidtvleyrklsaqta

    Sequence, based on observed residues (ATOM records):
    >6iw7L (L:)
ilpsfiehssfgvkesnpynklfeeriiflgvqvddasandimaqllvlesldpdrditm
yinspgggftslmaiydtmqyvradiqtvclgqaasaaavllaagtpgkrmalpnarvli
hqpslsgviqgqfsdleiqaaeiermrtlmettlarhtgkdagvirkdtdrdkiltaeea
kdygiidtvleyr

  • Chain 'M':
    Sequence, based on SEQRES records:
    >6iw7M (M:)
mrsnsqglsltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyins
pggsisagmaiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqpl
ggvtgsaadiaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfv
dhiitrahvngeaq

    Sequence, based on observed residues (ATOM records):
    >6iw7M (M:)
ltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyinspggsisagm
aiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqplggvtgsaad
iaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfvdhiit

  • Chain 'N':
    Sequence, based on SEQRES records:
    >6iw7N (N:)
mrsnsqglsltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyins
pggsisagmaiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqpl
ggvtgsaadiaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfv
dhiitrahvngeaq

    Sequence, based on observed residues (ATOM records):
    >6iw7N (N:)
ltdsvyerllseriiflgsevndeianrlcaqilllaaedaskdislyinspggsisagm
aiydtmvlapcdiatyamgmaasmgefllaagtkgkryalpharilmhqplggvtgsaad
iaiqaeqfavikkemfrlnaeftgqpierieadsdrdrwftaaealeygfvdhiit

  • Chain 'O':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7O (O:)
xll

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7P (P:)
xll

  • Chain 'Q':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7Q (Q:)
xll

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7R (R:)
xll

  • Chain 'T':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7T (T:)
xll

  • Chain 'U':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7U (U:)
xll

  • Chain 'V':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7V (V:)
xll

  • Chain 'W':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7W (W:)
xll

  • Chain 'X':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7X (X:)
xll

  • Chain 'Z':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7Z (Z:)
xll

  • Chain 'a':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7a (a:)
xll

  • Chain 'b':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7b (b:)
xll

  • Chain 'd':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7d (d:)
xll

  • Chain 'e':
    Sequence; same for both SEQRES and ATOM records:
    >6iw7e (e:)
xll