PDB entry 6iuo

View 6iuo on RCSB PDB site
Description: Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor
Class: transferase/inhibitor
Keywords: protein kinase, TRANSFERASE-INHIBITOR complex
Deposited on 2018-11-29, released 2019-10-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-23, with a file datestamp of 2019-10-18.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 4
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22455 (13-End)
      • expression tag (12)
      • engineered mutation (232)
    Domains in SCOPe 2.08: d6iuoa1, d6iuoa2
  • Heterogens: AWX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6iuoA (A:)
mgsshhhhhhssgllaglvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmdp
arpdqastvavkmlkdnasdkdladlvsemevmkligrhkniinllgvctqegplyvive
caakgnlreflrarrppgpdlspdgprssegplsfpvlvscayqvargmqylesrkcihr
dlaarnvlvtednvmkiadfglargvhhidyykktsngrlpvkwmapealfdevythqsd
vwsfgillweiftlggspypgipveelfsllreghrmdrpphcppelyglmrecwhaaps
qrptfkqlvealdkvllavsee

    Sequence, based on observed residues (ATOM records): (download) 
    >6iuoA (A:)
gllaglvsldlpldplwefprdrlvlgkplgegcfgqvvraeafgmarpdqastvavkml
kdnasdkdladlvsemevmkligrhkniinllgvctqegplyvivecaakgnlreflrar
rppgplsfpvlvscayqvargmqylesrkcihrdlaarnvlvtednvmkiadfgllpvkw
mapealfdevythqsdvwsfgillweiftlggspypgipveelfsllreghrmdrpphcp
pelyglmrecwhaapsqrptfkqlvealdkvllav