PDB entry 6iua

View 6iua on RCSB PDB site
Description: Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (S1678D)
Class: transport protein/protein binding
Keywords: importin, NLS, TRANSPORT PROTEIN, TRANSPORT PROTEIN-PROTEIN BINDING complex
Deposited on 2018-11-27, released 2019-01-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-02-20, with a file datestamp of 2019-02-15.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Importin subunit alpha-1
    Species: Mus musculus [TaxId:10090]
    Gene: Kpna2, Rch1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6iuaa_
  • Chain 'B':
    Compound: Peptide from TP53-binding protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53BP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12888 (0-21)
      • engineered mutation (13)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6iuaA (A:)
gtvnwsvedivkginsnnlesqlqatqaarkllsrekqppidniiraglipkfvsflgkt
dcspiqfesawaltniasgtseqtkavvdggaipafisllasphahiseqavwalgniag
dgsafrdlvikhgaidpllallavpdlstlacgylrnltwtlsnlcrnknpappldaveq
ilptlvrllhhndpevladscwaisyltdgpneriemvvkkgvvpqlvkllgatelpivt
palraignivtgtdeqtqkvidagalavfpslltnpktniqkeatwtmsnitagrqdqiq
qvvnhglvpflvgvlskadfktqkeaawaitnytsggtveqivylvhcgiieplmnllsa
kdtkiiqvildaisnifqaaeklgeteklsimieecggldkiealqrhenesvykaslnl
iekyfsv

    Sequence, based on observed residues (ATOM records): (download) 
    >6iuaA (A:)
nwsvedivkginsnnlesqlqatqaarkllsrekqppidniiraglipkfvsflgktdcs
piqfesawaltniasgtseqtkavvdggaipafisllasphahiseqavwalgniagdgs
afrdlvikhgaidpllallavpdlstlacgylrnltwtlsnlcrnknpappldaveqilp
tlvrllhhndpevladscwaisyltdgpneriemvvkkgvvpqlvkllgatelpivtpal
raignivtgtdeqtqkvidagalavfpslltnpktniqkeatwtmsnitagrqdqiqqvv
nhglvpflvgvlskadfktqkeaawaitnytsggtveqivylvhcgiieplmnllsakdt
kiiqvildaisnifqaaeklgeteklsimieecggldkiealqrhenesvykaslnliek
yf

  • Chain 'B':
    No sequence available.