PDB entry 6itt

View 6itt on RCSB PDB site
Description: Crystal structure of unactivated c-KIT in complex with compound
Class: oncoprotein
Keywords: Receptor tyrosine kinase DFG motif conformational control inhibitor, ONCOPROTEIN
Deposited on 2018-11-26, released 2019-11-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-27, with a file datestamp of 2019-11-22.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mast/stem cell growth factor receptor Kit
    Species: Homo sapiens [TaxId:9606]
    Gene: KIT, SCFR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6itta_
  • Chain 'B':
    Compound: Mast/stem cell growth factor receptor Kit
    Species: Homo sapiens [TaxId:9606]
    Gene: KIT, SCFR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ittb_
  • Heterogens: AWO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ittA (A:)
ylqkpmyevqwkvveeingnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvvea
taygliksdaamtvavkmlkpsahlterealmselkvlsylgnhmnivnllgactiggpt
lviteyccygdllnflrrkrdsficsktspaimeddelaldledllsfsyqvakgmafla
skncihrdlaarnillthgritkicdfglardikndsnyvvkgnarlpvkwmapesifnc
vytfesdvwsygiflwelfslgsspypgmpvdskfykmikegfrmlspehapaemydimk
tcwdadplkrptfkqivqliekqisestnhi

    Sequence, based on observed residues (ATOM records): (download) 
    >6ittA (A:)
ingnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvav
kmlkpsahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnfl
rrkrdseddelaldledllsfsyqvakgmaflaskncihrdlaarnillthgritkicdf
glardikndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwelfslgsspyp
gmpvdskfykmikegfrmlspehapaemydimktcwdadplkrptfkqivqliekqises
t

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ittB (B:)
ylqkpmyevqwkvveeingnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvvea
taygliksdaamtvavkmlkpsahlterealmselkvlsylgnhmnivnllgactiggpt
lviteyccygdllnflrrkrdsficsktspaimeddelaldledllsfsyqvakgmafla
skncihrdlaarnillthgritkicdfglardikndsnyvvkgnarlpvkwmapesifnc
vytfesdvwsygiflwelfslgsspypgmpvdskfykmikegfrmlspehapaemydimk
tcwdadplkrptfkqivqliekqisestnhi

    Sequence, based on observed residues (ATOM records): (download) 
    >6ittB (B:)
nnyvyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvavkml
kpsahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnflrrk
rmeddelaldledllsfsyqvakgmaflaskncihrdlaarnillthgritkicdfglar
dikndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwelfslgsspypgmpv
dskfykmikegfrmlspehapaemydimktcwdadplkrptfkqivqliekqisest