PDB entry 6ito

View 6ito on RCSB PDB site
Description: crystal structure of pyruvate kinase (pyk) from mycobacterium tuberculosis in complex with oxalate, amp and inhibitor ribose 5- phosphate
Deposited on 2018-11-24, released 2019-08-14
The last revision was dated 2019-09-25, with a file datestamp of 2019-09-20.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: pyruvate kinase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: pyk, pykA, Rv1617, MTCY01B2.09
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: pyruvate kinase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: pyk, pykA, Rv1617, MTCY01B2.09
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: pyruvate kinase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: pyk, pykA, Rv1617, MTCY01B2.09
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: pyruvate kinase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: pyk, pykA, Rv1617, MTCY01B2.09
    Database cross-references and differences (RAF-indexed):
  • Heterogens: MG, OXL, R5P, AMP, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6itoA (A:)
gghmtrrgkivctlgpatqrddlvralveagmdvarmnfshgdyddhkvayervrvasda
tgravgvladlqgpkirlgrfasgathwaegetvritvgacegshdrvsttykrlaqdav
agdrvlvddgkvalvvdavegddvvctvveggpvsdnkgislpgmnvtapalsekdiedl
tfalnlgvdmvalsfvrspadvelvhevmdrigrrvpviaklekpeaidnleaivlafda
vmvargdlgvelpleevplvqkraiqmarenakpvivatqmldsmiensrptraeasdva
navldgadalmlsgetsvgkyplaavrtmsriicaveenstaapplthiprtkrgvisya
ardigerldakalvaftqsgdtvrrlarlhtplpllaftawpevrsqlamtwgtetfivp
kmqstdgmirqvdksllelarykrgdlvvivagappgtvgstnlihvhrigeddv

    Sequence, based on observed residues (ATOM records):
    >6itoA (A:)
trrgkivctlgpatqrddlvralveagmdvarmnfshgdyddhkvayervrvasdatgra
vgvladlqgpkirlgrfasgathwaegetvritvgacegshdrvsttykrlaqdavagdr
vlvddgkvalvvdavegddvvctvveggpvsdnkgislpgmnvtapalsekdiedltfal
nlgvdmvalsfvrspadvelvhevmdrigrrvpviaklekpeaidnleaivlafdavmva
rgdlgvelpleevplvqkraiqmarenakpvivatqmldsmiensrptraeasdvanavl
dgadalmlsgetsvgkyplaavrtmsriicaveenstaapplthiprtkrgvisyaardi
gerldakalvaftqsgdtvrrlarlhtplpllaftawpevrsqlamtwgtetfivpkmqs
tdgmirqvdksllelarykrgdlvvivagappgtvgstnlihvhrigeddv

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6itoB (B:)
gghmtrrgkivctlgpatqrddlvralveagmdvarmnfshgdyddhkvayervrvasda
tgravgvladlqgpkirlgrfasgathwaegetvritvgacegshdrvsttykrlaqdav
agdrvlvddgkvalvvdavegddvvctvveggpvsdnkgislpgmnvtapalsekdiedl
tfalnlgvdmvalsfvrspadvelvhevmdrigrrvpviaklekpeaidnleaivlafda
vmvargdlgvelpleevplvqkraiqmarenakpvivatqmldsmiensrptraeasdva
navldgadalmlsgetsvgkyplaavrtmsriicaveenstaapplthiprtkrgvisya
ardigerldakalvaftqsgdtvrrlarlhtplpllaftawpevrsqlamtwgtetfivp
kmqstdgmirqvdksllelarykrgdlvvivagappgtvgstnlihvhrigeddv

    Sequence, based on observed residues (ATOM records):
    >6itoB (B:)
trrgkivctlgpatqrddlvralveagmdvarmnfshgdyddhkvayervrvasdatgra
vgvladlqgpkirlgrfasgathwaegetvritvgacegshdrvsttykrlaqdavagdr
vlvddgkvalvvdavegddvvctvveggpvsdnkgislpgmnvtapalsekdiedltfal
nlgvdmvalsfvrspadvelvhevmdrigrrvpviaklekpeaidnleaivlafdavmva
rgdlgvelpleevplvqkraiqmarenakpvivatqmldsmiensrptraeasdvanavl
dgadalmlsgetsvgkyplaavrtmsriicaveenstaapplthiprtkrgvisyaardi
gerldakalvaftqsgdtvrrlarlhtplpllaftawpevrsqlamtwgtetfivpkmqs
tdgmirqvdksllelarykrgdlvvivagappgtvgstnlihvhrigeddv

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6itoC (C:)
gghmtrrgkivctlgpatqrddlvralveagmdvarmnfshgdyddhkvayervrvasda
tgravgvladlqgpkirlgrfasgathwaegetvritvgacegshdrvsttykrlaqdav
agdrvlvddgkvalvvdavegddvvctvveggpvsdnkgislpgmnvtapalsekdiedl
tfalnlgvdmvalsfvrspadvelvhevmdrigrrvpviaklekpeaidnleaivlafda
vmvargdlgvelpleevplvqkraiqmarenakpvivatqmldsmiensrptraeasdva
navldgadalmlsgetsvgkyplaavrtmsriicaveenstaapplthiprtkrgvisya
ardigerldakalvaftqsgdtvrrlarlhtplpllaftawpevrsqlamtwgtetfivp
kmqstdgmirqvdksllelarykrgdlvvivagappgtvgstnlihvhrigeddv

    Sequence, based on observed residues (ATOM records):
    >6itoC (C:)
trrgkivctlgpatqrddlvralveagmdvarmnfshgdyddhkvayervrvasdatgra
vgvladlqgpkirlgrfasgathwaegetvritvgacegshdrvsttykrlaqdavagdr
vlvddgkvalvvdavegddvvctvveggpvsdnkgislpgmnvtapalsekdiedltfal
nlgvdmvalsfvrspadvelvhevmdrigrrvpviaklekpeaidnleaivlafdavmva
rgdlgvelpleevplvqkraiqmarenakpvivatqmldsmiensrptraeasdvanavl
dgadalmlsgetsvgkyplaavrtmsriicaveenstaapplthiprtkrgvisyaardi
gerldakalvaftqsgdtvrrlarlhtplpllaftawpevrsqlamtwgtetfivpkmqs
tdgmirqvdksllelarykrgdlvvivagappgtvgstnlihvhrigeddv

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6itoD (D:)
gghmtrrgkivctlgpatqrddlvralveagmdvarmnfshgdyddhkvayervrvasda
tgravgvladlqgpkirlgrfasgathwaegetvritvgacegshdrvsttykrlaqdav
agdrvlvddgkvalvvdavegddvvctvveggpvsdnkgislpgmnvtapalsekdiedl
tfalnlgvdmvalsfvrspadvelvhevmdrigrrvpviaklekpeaidnleaivlafda
vmvargdlgvelpleevplvqkraiqmarenakpvivatqmldsmiensrptraeasdva
navldgadalmlsgetsvgkyplaavrtmsriicaveenstaapplthiprtkrgvisya
ardigerldakalvaftqsgdtvrrlarlhtplpllaftawpevrsqlamtwgtetfivp
kmqstdgmirqvdksllelarykrgdlvvivagappgtvgstnlihvhrigeddv

    Sequence, based on observed residues (ATOM records):
    >6itoD (D:)
trrgkivctlgpatqrddlvralveagmdvarmnfshgdyddhkvayervrvasdatgra
vgvladlqgpkirlgrfasgathwaegetvritvgacegshdrvsttykrlaqdavagdr
vlvddgkvalvvdavegddvvctvveggpvsdnkgislpgmnvtapalsekdiedltfal
nlgvdmvalsfvrspadvelvhevmdrigrrvpviaklekpeaidnleaivlafdavmva
rgdlgvelpleevplvqkraiqmarenakpvivatqmldsmiensrptraeasdvanavl
dgadalmlsgetsvgkyplaavrtmsriicaveenstaapplthiprtkrgvisyaardi
gerldakalvaftqsgdtvrrlarlhtplpllaftawpevrsqlamtwgtetfivpkmqs
tdgmirqvdksllelarykrgdlvvivagappgtvgstnlihvhrigeddv