PDB entry 6iso

View 6iso on RCSB PDB site
Description: human sirt3 recognizing h3k4cr
Deposited on 2018-11-17, released 2019-01-23
The last revision was dated 2019-01-23, with a file datestamp of 2019-01-18.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT3, SIR2L3
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT3, SIR2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NTG7 (Start-273)
      • expression tag (274)
  • Chain 'C':
    Compound: arg-thr-lys-gln-thr-ala-arg
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ISO (0-6)
  • Chain 'D':
    Compound: arg-thr-lys-gln-thr-ala-arg
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ISO (0-6)
  • Chain 'E':
    Compound: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT3, SIR2L3
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: arg-thr-lys-gln-thr-ala-arg
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ISO (0-6)
  • Chain 'G':
    Compound: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT3, SIR2L3
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: arg-thr-lys-gln-thr-ala-arg
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ISO (0-6)
  • Chain 'I':
    Compound: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT3, SIR2L3
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: arg-thr-lys-gln-thr-ala-arg
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ISO (0-6)
  • Chain 'K':
    Compound: NAD-dependent protein deacetylase sirtuin-3, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT3, SIR2L3
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: arg-thr-lys-gln-thr-ala-arg
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ISO (0-End)
  • Heterogens: ZN, CRD, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6isoA (A:)
gklslqdvaeliraracqrvvvmvgagistpsgipdfrspgsglysnlqqydlpypeaif
elpfffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgip
asklveahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpq
rfllhvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdv
aqlgdvvhgveslvellgwteemrdlvqretgkla

    Sequence, based on observed residues (ATOM records):
    >6isoA (A:)
gklslqdvaeliraracqrvvvmvgagistpsgipdfrspysnlqqydlpypeaifelpf
ffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgipaskl
veahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpqrfll
hvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdvaqlg
dvvhgveslvellgwteemrdlvqretgkl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6isoB (B:)
gklslqdvaeliraracqrvvvmvgagistpsgipdfrspgsglysnlqqydlpypeaif
elpfffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgip
asklveahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpq
rfllhvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdv
aqlgdvvhgveslvellgwteemrdlvqretgkla

    Sequence, based on observed residues (ATOM records):
    >6isoB (B:)
klslqdvaeliraracqrvvvmvgagistpsgipdfrsqydlpypeaifelpfffhnpkp
fftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgipasklveahgtf
asatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpqrfllhvvdfpm
adlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdvaqlgdvvhgve
slvellgwteemrdlvqretgkla

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6isoC (C:)
rtkqtar

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >6isoD (D:)
rtkqtar

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6isoE (E:)
gklslqdvaeliraracqrvvvmvgagistpsgipdfrspgsglysnlqqydlpypeaif
elpfffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgip
asklveahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpq
rfllhvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdv
aqlgdvvhgveslvellgwteemrdlvqretgkla

    Sequence, based on observed residues (ATOM records):
    >6isoE (E:)
klslqdvaeliraracqrvvvmvgagistpsgipdsnlqqydlpypeaifelpfffhnkp
fftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgipasklveahgtf
asatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpqrfllhvvdfpm
adlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdvaqlgdvvhgve
slvellgwteemrdlvqretgkl

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >6isoF (F:)
rtkqtar

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6isoG (G:)
gklslqdvaeliraracqrvvvmvgagistpsgipdfrspgsglysnlqqydlpypeaif
elpfffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgip
asklveahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpq
rfllhvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdv
aqlgdvvhgveslvellgwteemrdlvqretgkla

    Sequence, based on observed residues (ATOM records):
    >6isoG (G:)
gklslqdvaeliraracqrvvvmvgagistpsgippypeaifelpfffhnpkpfftlake
lypgnykpnvthyflrllhdkglllrlytqnidglervsgipasklveahgtfasatctv
qrpfpgediradvmadrvprcpvctgvvkpdivffgeplpqrfllhvvdfpmadlllilg
tslevepfaslteavrssvprllinrdlvgplawhprsrdvaqlgdvvhgveslvellgw
teemrdlvqretgkl

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records:
    >6isoH (H:)
rtkqtar

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6isoI (I:)
gklslqdvaeliraracqrvvvmvgagistpsgipdfrspgsglysnlqqydlpypeaif
elpfffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgip
asklveahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpq
rfllhvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdv
aqlgdvvhgveslvellgwteemrdlvqretgkla

    Sequence, based on observed residues (ATOM records):
    >6isoI (I:)
klslqdvaeliraracqrvvvmvgagistpspypeaifelpfffhnpkpfftlakelypg
pnvthyflrllhdkglllrlytqnidglervsgipasklveahgtfasatctvcqrpfpg
ediradvmadrvprcpvctgvvkpdivffgeplpqrfllhvvdfpmadlllilgtsleve
pfaslteavrssvprllinrdlvgplawhprsrdvaqlgdvvhgveslvellgwteemrd
lvqretgk

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records:
    >6isoJ (J:)
rtkqtar

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6isoK (K:)
gklslqdvaeliraracqrvvvmvgagistpsgipdfrspgsglysnlqqydlpypeaif
elpfffhnpkpfftlakelypgnykpnvthyflrllhdkglllrlytqnidglervsgip
asklveahgtfasatctvcqrpfpgediradvmadrvprcpvctgvvkpdivffgeplpq
rfllhvvdfpmadlllilgtslevepfaslteavrssvprllinrdlvgplawhprsrdv
aqlgdvvhgveslvellgwteemrdlvqretgkla

    Sequence, based on observed residues (ATOM records):
    >6isoK (K:)
lslqdvaeliraracqrvvvmvgagistpsgipykpnvthyflrllhdkglllrlytqni
dglervsgipasklveahgtfactgvvkpdivffgeplpqrfllhvvdfpmadlllilgt
slevepfaslteavrssvprllinrdlvgplawhprsrdvaqlgdvvhgveslvellgwt
eemrdlvqretgkl

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6isoL (L:)
rtkqtar

    Sequence, based on observed residues (ATOM records):
    >6isoL (L:)
rtkqta