PDB entry 6irg

View 6irg on RCSB PDB site
Description: structure of the human glun1/glun2a nmda receptor in the glutamate/glycine-bound state at ph 6.3, class ii
Deposited on 2018-11-12, released 2019-01-16
The last revision was dated 2019-06-05, with a file datestamp of 2019-05-30.
Experiment type: EM
Resolution: 5.5 Å
R-factor: N/A
AEROSPACI score: 0.03 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutamate receptor ionotropic, NMDA 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Grin1, Nmdar1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05586
      • engineered mutation (611)
  • Chain 'B':
    Compound: Glutamate receptor ionotropic, NMDA 2A
    Species: Homo sapiens [TaxId:9606]
    Gene: Grin2a
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12879 (Start-840)
      • engineered mutation (656)
  • Chain 'C':
    Compound: Glutamate receptor ionotropic, NMDA 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Grin1, Nmdar1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05586
      • engineered mutation (611)
  • Chain 'D':
    Compound: Glutamate receptor ionotropic, NMDA 2A
    Species: Homo sapiens [TaxId:9606]
    Gene: Grin2a
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12879 (Start-840)
      • engineered mutation (656)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6irgA (A:)
mstmrlltlallfscsvaraacdpkivnigavlstrkheqmfreavnqankrhgswkiql
natsvthkpnaiqmalsvcedlissqvyailvshpptpndhftptpvsytagfyripvlg
lttrmsiysdksihlsflrtvppyshqssvwfemmrvyswnhiillvsddhegraaqkrl
etlleereskaekvlqfdpgtknvtallmeakelearviilsaseddaatvyraaamlnm
tgsgyvwlvgereisgnalryapdgilglqlingknesahisdavgvvaqavhelleken
itdpprgcvgntniwktgplfkrvlmsskyadgvtgrvefnedgdrkfanysimnlqnrk
lvqvgiyngthvipndrkiiwpggetekprgyqmstrlkivtihqepfvyvkptlsdgtc
keeftvngdpvkkvictgpndtspgsprhtvpqccygfcidlliklartmnftyevhlva
dgkfgtqervnnsnkkewngmmgellsgqadmivapltinneraqyiefskpfkyqglti
lvkkeiprstldsfmqpfqstlwllvglsvhvvavmlylldrfspfgrfkvnseeeeeda
ltlssamwfswrvllnsgigegaprsfsarilgmvwagfamiivasytanlaaflvldrp
eeritgindprlrnpsdkfiyatvkqssvdiyfrrqvelstmyrhmekhnyesaaeaiqa
vrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkdspwkqnvslsilksh
engfmedldktwvryqecdsrsnapatltfenmagvfmlvaggivagiflifieiaykrh
kdarrkq

    Sequence, based on observed residues (ATOM records):
    >6irgA (A:)
kivnigavlstrkheqmfreavnqankrhgswkiqlnatsvthkpnaiqmalsvcedlis
sqvyailvshpptpndhftptpvsytagfyripvlglttrmsiysdksihlsflrtvppy
shqssvwfemmrvyswnhiillvsddhegraaqkrletlleereskaekvlqfdpgtknv
tallmeakelearviilsaseddaatvyraaamlnmtgsgyvwlvgereisgnalryapd
gilglqlingknesahisdavgvvaqavhellekenitdpprgcvgntniwktgplfkrv
lmsskyadgvtgrvefnedgdrkfanysimnlqnrklvqvgiyngthvipndrkiiwpgg
etekprgyqmstrlkivtihqepfvyvkptlsdgtckeeftvngdpvkkvictgpndtsp
gsprhtvpqccygfcidlliklartmnftyevhlvadgkfgtqervnnsnkkewngmmge
llsgqadmivapltinneraqyiefskpfkyqgltilvkkeiprsfmqpfqstlwllvgl
svhvvavmlylldrfsltlssamwfswrvllnsgigegsfsarilgmvwagfamiivasy
tanlaaflvldritgindprlrnpsdkfiyatvkqssvdiyfrrqvelstmyrhmekhny
esaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkdspwkqn
vslsilkshengfmedldktwvryqecdsrstfenmagvfmlvaggivagiflifieiay
krhkdar

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6irgB (B:)
mgrvgywtllvlpallvwrgpapsaaaekgppalniavmlghshdvterelrtlwgpeqa
aglpldvnvvallmnrtdpkslithvcdlmsgarihglvfgddtdqeavaqmldfissht
fvpilgihggasmimadkdptstffqfgasiqqqatvmlkimqdydwhvfslvttifpgy
refisfvkttvdnsfvgwdmqnvitldtsfedaktqvqlkkihssvillycskdeavlil
searslgltgydffwivpslvsgntelipkefpsglisvsyddwdyslearvrdgigilt
taassmlekfsyipeakascygqmerpevpmhtlhpfmvnvtwdgkdlsfteegyqvhpr
lvvivlnkdrewekvgkwenhtlslrhavwpryksfsdcepddnhlsivtleeapfvive
didpltetcvrntvpcrkfvkinnstnegmnvkkcckgfcidilkklsrtvkftydlylv
tngkhgkkvnnvwngmigevvyqravmavgsltineersevvdfsvpfvetgisvmvsrs
ngtvspsaflepfsasvwvmmfvmllivsaiavfvfeyfspvgynrnlakgkaphgpsft
igkaiwllwglvfnnsvpvqnpkgttskimvsvwaffaviflasytanlaafmiqrrfvd
qvtglsdkkfqrphdysppfrfgtvpngsternirnnypymhqymtkfnqkgvedalvsl
ktgkldafiydaavlnykagrdegcklvtigsgyifattgygialqkgspwkrqidlall
qfvgdgemeeletlwltgichneknevmssqldidnmagvfymlaaamalslitfiwehl
f

    Sequence, based on observed residues (ATOM records):
    >6irgB (B:)
lniavmlghshdvterelrtlwgpeqaaglpldvnvvallmnrtdpkslithvcdlmsga
rihglvfgddtdqeavaqmldfisshtfvpilgihggasmimadkdptstffqfgasiqq
qatvmlkimqdydwhvfslvttifpgyrefisfvkttvdnsfvgwdmqnvitldtsfeda
ktqvqlkkihssvillycskdeavlilsearslgltgydffwivpslvsgntelipkefp
sglisvsyddwdyslearvrdgigilttaassmlekfsyipeakascygqmerpevpmht
lhpfmvnvtwdgkdlsfteegyqvhprlvvivlnkdrewekvgkwenhtlslrhavwpry
ksfsdepddnhlsivtleeapfvivedidpltetcvrntvpcrkfvkinnstnegmnvkk
cckgfcidilkklsrtvkftydlylvtngkhgkkvnnvwngmigevvyqravmavgslti
neersevvdfsvpfvetgisvmvsasvwvmmfvmllivsaiavfvfeyfspsftigkaiw
llwglvfttskimvsvwaffaviflasytanlaafmiqrfvdqvtglsdkkfqrphdysp
pfrfgtvpngsternirnnypymhqymtkfnqkgvedalvslktgkldafiydaavlnyk
agrdegcklvtigsgyifatqkgspwkrqidlallqfvgdgemeeletlwltgichnekn
evmsidnmagvfymlaaamalslitfiwehlf

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6irgC (C:)
mstmrlltlallfscsvaraacdpkivnigavlstrkheqmfreavnqankrhgswkiql
natsvthkpnaiqmalsvcedlissqvyailvshpptpndhftptpvsytagfyripvlg
lttrmsiysdksihlsflrtvppyshqssvwfemmrvyswnhiillvsddhegraaqkrl
etlleereskaekvlqfdpgtknvtallmeakelearviilsaseddaatvyraaamlnm
tgsgyvwlvgereisgnalryapdgilglqlingknesahisdavgvvaqavhelleken
itdpprgcvgntniwktgplfkrvlmsskyadgvtgrvefnedgdrkfanysimnlqnrk
lvqvgiyngthvipndrkiiwpggetekprgyqmstrlkivtihqepfvyvkptlsdgtc
keeftvngdpvkkvictgpndtspgsprhtvpqccygfcidlliklartmnftyevhlva
dgkfgtqervnnsnkkewngmmgellsgqadmivapltinneraqyiefskpfkyqglti
lvkkeiprstldsfmqpfqstlwllvglsvhvvavmlylldrfspfgrfkvnseeeeeda
ltlssamwfswrvllnsgigegaprsfsarilgmvwagfamiivasytanlaaflvldrp
eeritgindprlrnpsdkfiyatvkqssvdiyfrrqvelstmyrhmekhnyesaaeaiqa
vrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkdspwkqnvslsilksh
engfmedldktwvryqecdsrsnapatltfenmagvfmlvaggivagiflifieiaykrh
kdarrkq

    Sequence, based on observed residues (ATOM records):
    >6irgC (C:)
kivnigavlstrkheqmfreavnqankrhgswkiqlnatsvthkpnaiqmalsvcedlis
sqvyailvshpptpndhftptpvsytagfyripvlglttrmsiysdksihlsflrtvppy
shqssvwfemmrvyswnhiillvsddhegraaqkrletlleereskaekvlqfdpgtknv
tallmeakelearviilsaseddaatvyraaamlnmtgsgyvwlvgereisgnalryapd
gilglqlingknesahisdavgvvaqavhellekenitdpprgcvgntniwktgplfkrv
lmsskyadgvtgrvefnedgdrkfanysimnlqnrklvqvgiyngthvipndrkiiwpgg
etekprgyqmstrlkivtihqepfvyvkptlsdgtckeeftvngdpvkkvictgpndtsp
gsprhtvpqccygfcidlliklartmnftyevhlvadgkfgtqervnnsnkkewngmmge
llsgqadmivapltinneraqyiefskpfkyqgltilvkkeiprsfmqpfqstlwllvgl
svhvvavmlylldrfsltlssamwfswrvllnsgigegsfsarilgmvwagfamiivasy
tanlaaflvldritgindprlrnpsdkfiyatvkqssvdiyfrrqvelstmyrhmekhny
esaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgelffrsgfgigmrkdspwkqn
vslsilkshengfmedldktwvryqecdsrstfenmagvfmlvaggivagiflifieiay
krhkdar

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6irgD (D:)
mgrvgywtllvlpallvwrgpapsaaaekgppalniavmlghshdvterelrtlwgpeqa
aglpldvnvvallmnrtdpkslithvcdlmsgarihglvfgddtdqeavaqmldfissht
fvpilgihggasmimadkdptstffqfgasiqqqatvmlkimqdydwhvfslvttifpgy
refisfvkttvdnsfvgwdmqnvitldtsfedaktqvqlkkihssvillycskdeavlil
searslgltgydffwivpslvsgntelipkefpsglisvsyddwdyslearvrdgigilt
taassmlekfsyipeakascygqmerpevpmhtlhpfmvnvtwdgkdlsfteegyqvhpr
lvvivlnkdrewekvgkwenhtlslrhavwpryksfsdcepddnhlsivtleeapfvive
didpltetcvrntvpcrkfvkinnstnegmnvkkcckgfcidilkklsrtvkftydlylv
tngkhgkkvnnvwngmigevvyqravmavgsltineersevvdfsvpfvetgisvmvsrs
ngtvspsaflepfsasvwvmmfvmllivsaiavfvfeyfspvgynrnlakgkaphgpsft
igkaiwllwglvfnnsvpvqnpkgttskimvsvwaffaviflasytanlaafmiqrrfvd
qvtglsdkkfqrphdysppfrfgtvpngsternirnnypymhqymtkfnqkgvedalvsl
ktgkldafiydaavlnykagrdegcklvtigsgyifattgygialqkgspwkrqidlall
qfvgdgemeeletlwltgichneknevmssqldidnmagvfymlaaamalslitfiwehl
f

    Sequence, based on observed residues (ATOM records):
    >6irgD (D:)
lniavmlghshdvterelrtlwgpeqaaglpldvnvvallmnrtdpkslithvcdlmsga
rihglvfgddtdqeavaqmldfisshtfvpilgihggasmimadkdptstffqfgasiqq
qatvmlkimqdydwhvfslvttifpgyrefisfvkttvdnsfvgwdmqnvitldtsfeda
ktqvqlkkihssvillycskdeavlilsearslgltgydffwivpslvsgntelipkefp
sglisvsyddwdyslearvrdgigilttaassmlekfsyipeakascygqmerpevpmht
lhpfmvnvtwdgkdlsfteegyqvhprlvvivlnkdrewekvgkwenhtlslrhavwpry
ksfsdepddnhlsivtleeapfvivedidpltetcvrntvpcrkfvkinnstnegmnvkk
cckgfcidilkklsrtvkftydlylvtngkhgkkvnnvwngmigevvyqravmavgslti
neersevvdfsvpfvetgisvmvsasvwvmmfvmllivsaiavfvfeyfspsftigkaiw
llwglvfttskimvsvwaffaviflasytanlaafmiqrfvdqvtglsdkkfqrphdysp
pfrfgtvpngsternirnnypymhqymtkfnqkgvedalvslktgkldafiydaavlnyk
agrdegcklvtigsgyifatqkgspwkrqidlallqfvgdgemeeletlwltgichnekn
evmsidnmagvfymlaaamalslitfiwehlf