PDB entry 6iqn

View 6iqn on RCSB PDB site
Description: Crystal structure of TrkA kinase with ligand
Class: transferase
Keywords: Inhibitor, TRANSFERASE
Deposited on 2018-11-08, released 2020-01-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-22, with a file datestamp of 2020-01-17.
Experiment type: XRAY
Resolution: 2.54 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: high affinity nerve growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NTRK1, MTC, TRK, TRKA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04629 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d6iqna1, d6iqna2
  • Chain 'B':
    Compound: high affinity nerve growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NTRK1, MTC, TRK, TRKA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04629 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d6iqnb1, d6iqnb2
  • Heterogens: AQ6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6iqnA (A:)
svhhikrrdivlkwelgegafgkvflaechnllpeqdkmlvavkalkeasesarqdfqre
aelltmlqhqhivrffgvctegrpllmvfeymrhgdlnrflrshgpdakllaggedvapg
plglgqllavasqvaagmvylaglhfvhrdlatrnclvgqglvvkigdfgmsrdiystdy
yrvggrtmlpirwmppesilyrkfttesdvwsfgvvlweiftygkqpwyqlsnteaidci
tqgrelerpracppevyaimrgcwqrepqqrhsikdvharlqalaqappvyldvlg

    Sequence, based on observed residues (ATOM records): (download) 
    >6iqnA (A:)
svhhikrrdivlkwelgegafgkvflaechnllpkmlvavkalkesarqdfqreaelltm
lqhqhivrffgvctegrpllmvfeymrhgdlnrflrshgpdakllaggedvapgplglgq
llavasqvaagmvylaglhfvhrdlatrnclvgqglvvkigdftdyyrtmlpirwmppes
ilyrkfttesdvwsfgvvlweiftygkqpwyqlsnteaidcitqgrelerpracppevya
imrgcwqrepqqrhsikdvharlqalaqappv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6iqnB (B:)
svhhikrrdivlkwelgegafgkvflaechnllpeqdkmlvavkalkeasesarqdfqre
aelltmlqhqhivrffgvctegrpllmvfeymrhgdlnrflrshgpdakllaggedvapg
plglgqllavasqvaagmvylaglhfvhrdlatrnclvgqglvvkigdfgmsrdiystdy
yrvggrtmlpirwmppesilyrkfttesdvwsfgvvlweiftygkqpwyqlsnteaidci
tqgrelerpracppevyaimrgcwqrepqqrhsikdvharlqalaqappvyldvlg

    Sequence, based on observed residues (ATOM records): (download) 
    >6iqnB (B:)
svhhikrrdivlkwelgegafgkvflaechnlldkmlvavkaldfqreaelltmlqhqhi
vrffgvctegrpllmvfeymrhgdlnrflrshgpdakllaggedvapgplglgqllavas
qvaagmvylaglhfvhrdlatrnclvgqglvvkigdfglpirwmppesilyrkfttesdv
wsfgvvlweiftygkqpwyqlsnteaidcitqgrelerpracppevyaimrgcwqrepqq
rhsikdvharlqalaqap