PDB entry 6iq4

View 6iq4 on RCSB PDB site
Description: Nucleosome core particle cross-linked with a hetero-binuclear molecule possessing RAPTA and gold(I) 4-(diphenylphosphino)benzoic acid groups.
Class: DNA binding protein/DNA
Keywords: nucleosome, anticancer, organometallic, cross-link, gold, ruthenium, DNA BINDING PROTEIN-DNA complex
Deposited on 2018-11-06, released 2019-10-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-06, with a file datestamp of 2019-11-01.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Histone H3.1
  Species: Homo sapiens [TaxId:9606]
  Gene: H3C1, H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J
  Database cross-references and differences (RAF-indexed):
  • Uniprot P68431 (0-97)
  Domains in SCOPe 2.08: d6iq4a_
• Chain 'B':
  Compound: histone h4
  Species: Homo sapiens [TaxId:9606]
  Gene: HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62805 (0-81)
  Domains in SCOPe 2.08: d6iq4b_
• Chain 'C':
  Compound: Histone H2A type 1-B/E
  Species: Homo sapiens [TaxId:9606]
  Gene: HIST1H2AB, H2AFM, HIST1H2AE, H2AFA
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04908 (0-105)
  Domains in SCOPe 2.08: d6iq4c_
• Chain 'D':
  Compound: Histone H2B type 1-J
  Species: Homo sapiens [TaxId:9606]
  Gene: HIST1H2BJ, H2BFR
  Database cross-references and differences (RAF-indexed):
  • Uniprot P06899 (0-94)
  Domains in SCOPe 2.08: d6iq4d_
• Chain 'E':
  Compound: Histone H3.1
  Species: Homo sapiens [TaxId:9606]
  Gene: H3C1, H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J
  Database cross-references and differences (RAF-indexed):
  • Uniprot P68431 (0-97)
  Domains in SCOPe 2.08: d6iq4e_
• Chain 'F':
  Compound: histone h4
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P62805 (0-86)
  Domains in SCOPe 2.08: d6iq4f_
• Chain 'G':
  Compound: Histone H2A type 1-B/E
  Species: Homo sapiens [TaxId:9606]
  Gene: HIST1H2AB, H2AFM, HIST1H2AE, H2AFA
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04908 (0-105)
  Domains in SCOPe 2.08: d6iq4g_
• Chain 'H':
  Compound: Histone H2B type 1-J
  Species: Homo sapiens [TaxId:9606]
  Gene: HIST1H2BJ, H2BFR
  Database cross-references and differences (RAF-indexed):
  • Uniprot P06899 (0-94)
  Domains in SCOPe 2.08: d6iq4h_
• Chain 'I':
  Compound: DNA (145-mer)
  Species: Homo sapiens [TaxId:9606]
  
• Chain 'J':
  Compound: DNA (145-mer)
  Species: Homo sapiens [TaxId:9606]
  
• Heterogens: D0X, XIS, AU, MG, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6iq4A (A:)
  phryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavmalqeace
  aylvglfedtnlcaihakrvtimpkdiqlarrirgera
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6iq4B (B:)
  vlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtytehakrkt
  vtamdvvyalkrqgrtlygfgg
  

  
  
• Chain 'C':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6iq4C (C:)
  aktrssraglqfpvgrvhrllrkgnyservgagapvylaavleyltaeilelagnaardn
  kktriiprhlqlairndeelnkllgrvtiaqggvlpniqavllpkk
  

  
  
• Chain 'D':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6iq4D (D:)
  rsrkesysiyvykvlkqvhpdtgisskamgimnsfvndiferiageasrlahynkrstit
  sreiqtavrlllpgelakhavsegtkavtkytsak
  

  
  
• Chain 'E':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6iq4E (E:)
  phryrpgtvalreirryqkstellirklpfqrlvreiaqdfktdlrfqssavmalqeace
  aylvglfedtnlcaihakrvtimpkdiqlarrirgera
  

  
  
• Chain 'F':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6iq4F (F:)
  krhrkvlrdniqgitkpairrlarrggvkrisgliyeetrgvlkvflenvirdavtyteh
  akrktvtamdvvyalkrqgrtlygfgg
  

  
  
• Chain 'G':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6iq4G (G:)
  aktrssraglqfpvgrvhrllrkgnyservgagapvylaavleyltaeilelagnaardn
  kktriiprhlqlairndeelnkllgrvtiaqggvlpniqavllpkk
  

  
  
• Chain 'H':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >6iq4H (H:)
  rsrkesysiyvykvlkqvhpdtgisskamgimnsfvndiferiageasrlahynkrstit
  sreiqtavrlllpgelakhavsegtkavtkytsak
  

  
  
• Chain 'I':
  No sequence available.
  
  
• Chain 'J':
  No sequence available.