PDB entry 6in3

View 6in3 on RCSB PDB site
Description: Crystal structure of DOT1L in complex with 18-Crown-6
Class: transferase
Keywords: histone H3K79 methyltransferase, TRANSFERASE
Deposited on 2018-10-24, released 2019-10-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-30, with a file datestamp of 2019-10-25.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-79 specific
    Species: Homo sapiens [TaxId:9606]
    Gene: DOT1L, KIAA1814, KMT4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6in3a_
  • Heterogens: O4B, SAH, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6in3A (A:)
mklelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlid
ydtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdp
eklnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhh
ygvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnn
fafgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgs
vswtgkpvsyylhtidrtilenyfsslklehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6in3A (A:)
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsvtdpek
lnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhyg
vekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfa
fgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelspvsyylh
tidrtilenyfsslk