PDB entry 6imr

View 6imr on RCSB PDB site
Description: Crystal structure of PDE4D complexed with a novel inhibitor
Class: hydrolase/hydrolase inhibitor
Keywords: PDE4D, Inhibitor, Complex, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2018-10-23, released 2019-10-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-23, with a file datestamp of 2019-10-18.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6imra_
  • Chain 'B':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4D, DPDE3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6imrb_
  • Heterogens: ZN, MG, AJX, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6imrA (A:)
mgsshhhhhhssglvprgshmteqedvlakeledvnkwglhvfriaelsgnrpltvimht
ifqerdllktfkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleav
ftdleilaaifasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqee
ncdifqnltkkqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnys
driqvlqnmvhcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnas
veksqvgfidyivhplwetwadlvhpdaqdildtlednrewyqstipqs

    Sequence, based on observed residues (ATOM records): (download) 
    >6imrA (A:)
eqedvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlityl
mtledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhpg
vsnqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvid
ivlatdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkpl
qlyrqwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwad
lvhpdaqdildtlednrewyqstip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6imrB (B:)
mgsshhhhhhssglvprgshmteqedvlakeledvnkwglhvfriaelsgnrpltvimht
ifqerdllktfkipvdtlitylmtledhyhadvayhnnihaadvvqsthvllstpaleav
ftdleilaaifasaihdvdhpgvsnqflintnselalmyndssvlenhhlavgfkllqee
ncdifqnltkkqrqslrkmvidivlatdmskhmnlladlktmvetkkvtssgvllldnys
driqvlqnmvhcadlsnptkplqlyrqwtdrimeeffrqgdrerergmeispmcdkhnas
veksqvgfidyivhplwetwadlvhpdaqdildtlednrewyqstipqs

    Sequence, based on observed residues (ATOM records): (download) 
    >6imrB (B:)
edvlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlitylmt
ledhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhpgvs
nqflintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvidiv
latdmskhmnlladlktmvetkkvtvllldnysdriqvlqnmvhcadlsnptkplqlyrq
wtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwadlvhpd
aqdildtlednrewyqstip