PDB entry 6ilh

View 6ilh on RCSB PDB site
Description: Crystal Structure of human lysyl-tRNA synthetase L350H mutant
Class: ligase
Keywords: lysyl-tRNA synthetase, LysRS, disease related mutant, LIGASE
Deposited on 2018-10-18, released 2019-02-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-10, with a file datestamp of 2019-04-05.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-tRNA ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: KARS, KIAA0070
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15046
      • engineered mutation (281)
    Domains in SCOPe 2.08: d6ilha1, d6ilha2
  • Chain 'B':
    Compound: Lysine-tRNA ligase
    Species: Homo sapiens [TaxId:9606]
    Gene: KARS, KIAA0070
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15046
      • engineered mutation (281)
    Domains in SCOPe 2.08: d6ilhb1, d6ilhb2
  • Heterogens: KAA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ilhA (A:)
msvdpnqyykirsqaihqlkvngedpyphkfhvdisltdfiqkyshlqpgdhltditlkv
agrihakrasggklifydlrgegvklqvmansrnykseeefihinnklrrgdiigvqgnp
gktkkgelsiipyeitllspclhmlphlhfglkdketryrqryldlilndfvrqkfiirs
kiityirsfldelgfleietpmmniipggavakpfityhneldmnlymriapelyhkmlv
vggidrvyeigrqfrnegidlthnpefttcefymayadyhdhmeitekmvsgmvkhitgs
ykvtyhpdgpegqaydvdftppfrrinmveelekalgmklpetnlfeteetrkilddicv
akavecppprttarlldklvgeflevtcinptficdhpqimsplakwhrskeglterfel
fvmkkeicnaytelndpmrqrqlfeeqakakaagddeamfidenfctaleyglpptagwg
mgidrvamfltdsnnikevllfpamkpedkkenlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6ilhA (A:)
vdpnqyykirsqaihqlkvngedpyphkfhvdisltdfiqkyshlqpgdhltditlkvag
rihakrasggklifydlrgegvklqvmansrnykseeefihinnklrrgdiigvqgnpgk
tkkgelsiipyeitllspclhmlphglkdketryrqryldlilndfvrqkfiirskiity
irsfldelgfleietpmmniipggavakpfityhneldmnlymriapelyhkmlvvggid
rvyeigrqfrnegidlthnpefttcefymayadyhdhmeitekmvsgmvkhitgsykvty
hpdgpegqaydvdftppfrrinmveelekalgmklpetnlfeteetrkilddicvakave
cppprttarlldklvgeflevtcinptficdhpqimsplakwhrskeglterfelfvmkk
eicnaytelndpmrqrqlfeeqakakaagddeamfidenfctaleyglpptagwgmgidr
vamfltdsnnikevllfpamkp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ilhB (B:)
msvdpnqyykirsqaihqlkvngedpyphkfhvdisltdfiqkyshlqpgdhltditlkv
agrihakrasggklifydlrgegvklqvmansrnykseeefihinnklrrgdiigvqgnp
gktkkgelsiipyeitllspclhmlphlhfglkdketryrqryldlilndfvrqkfiirs
kiityirsfldelgfleietpmmniipggavakpfityhneldmnlymriapelyhkmlv
vggidrvyeigrqfrnegidlthnpefttcefymayadyhdhmeitekmvsgmvkhitgs
ykvtyhpdgpegqaydvdftppfrrinmveelekalgmklpetnlfeteetrkilddicv
akavecppprttarlldklvgeflevtcinptficdhpqimsplakwhrskeglterfel
fvmkkeicnaytelndpmrqrqlfeeqakakaagddeamfidenfctaleyglpptagwg
mgidrvamfltdsnnikevllfpamkpedkkenlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6ilhB (B:)
dpnqyykirsqaihqlkvngedpyphkfhvdisltdfiqkyshlqpgdhltditlkvagr
ihakrasggklifydlrgegvklqvmansrnykseeefihinnklrrgdiigvqgnpgkt
kkgelsiipyeitllspclhmlphlhfglkdketryrqryldlilndfvrqkfiirskii
tyirsfldelgfleietpmmniipggavakpfityhneldmnlymriapelyhkmlvvgg
idrvyeigrqfrnegidlthnpefttcefymayadyhdhmeitekmvsgmvkhitgsykv
tyhpdgpegqaydvdftppfrrinmveelekalgmklpetnlfeteetrkilddicvaka
vecppprttarlldklvgeflevtcinptficdhpqimsplakwhrskeglterfelfvm
kkeicnaytelndpmrqrqlfeeqakakaagddeamfidenfctaleyglpptagwgmgi
drvamfltdsnnikevllfpamkp