PDB entry 6il3

View 6il3 on RCSB PDB site
Description: Crystal structure of the FLT3 kinase bound to a small molecule inhibitor
Class: transferase
Keywords: receptor tyrosine kinase type I inhibitor ATP binding domain DFG-in, SIGNALING PROTEIN, TRANSFERASE
Deposited on 2018-10-16, released 2018-12-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-12-12, with a file datestamp of 2018-12-07.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor-type tyrosine-protein kinase FLT3
    Species: Homo sapiens [TaxId:9606]
    Gene: FLT3, CD135, FLK2, STK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6il3a_
  • Heterogens: A9R, PO4, CXS, GOL, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6il3A (A:)
msyyhhhhhhdydipttenlyfqsiahkykkqfryesqlqmvqvtgssdneyfyvdfrey
eydlkwefprenlefgkvlgsgafgkvmnataygisktgvsiqvavkmlkekadsserea
lmselkmmtqlgshenivnllgactlsgpiylifeyccygdllnylrskrekfsedeiey
enqkrleeeedlnvltfedllcfayqvakgmeflefkscvhrdlaarnvlvthgkvvkic
dfglardimsdsnyvvrgnarlpvkwmapeslfegiytiksdvwsygillweifslgvnp
ypgipvdanfykliqngfkmdqpfyateeiyiimqscwafdsrkrpsfpnltsflgcqla
daeeamyqnv

    Sequence, based on observed residues (ATOM records): (download) 
    >6il3A (A:)
qfryesqlqmvqvtgssdneyfyvdfreyeydlkwefprenlefgkvlgsgafgkvmnat
aygisktgvsiqvavkmlkekadsserealmselkmmtqlgshenivnllgactlsgpiy
lifeyccygdllnylrskrekfsnvltfedllcfayqvakgmeflefkscvhrdlaarnv
lvthgkvvkicdfglardimsdsnyvvrgnarlpvkwmapeslfegiytiksdvwsygil
lweifslgvnpypgipvdanfykliqngfkmdqpfyateeiyiimqscwafdsrkrpsfp
nltsflgcql