PDB entry 6iid

View 6iid on RCSB PDB site
Description: human exog-h140a in complex with rna-dna chimeric duplex
Deposited on 2018-10-04, released 2019-04-03
The last revision was dated 2019-06-19, with a file datestamp of 2019-06-14.
Experiment type: XRAY
Resolution: 2.99 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: nuclease exog, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOG, ENDOGL1, ENDOGL2, ENGL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y2C4
      • engineered mutation (119)
  • Chain 'B':
    Compound: nuclease exog, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOG, ENDOGL1, ENDOGL2, ENGL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y2C4
      • engineered mutation (119)
  • Chain 'C':
    Compound: nuclease exog, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOG, ENDOGL1, ENDOGL2, ENGL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y2C4
      • engineered mutation (119)
  • Chain 'D':
    Compound: nuclease exog, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: EXOG, ENDOGL1, ENDOGL2, ENGL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y2C4
      • engineered mutation (119)
  • Chain 'E':
    Compound: DNA/RNA (5'-r(p*cp*gp*gp*gp*a)-d(p*t)-r(p*g)-d(p*t)-r(p*cp*ap*cp*g)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'F':
    Compound: DNA (5'-d(*cp*gp*tp*gp*ap*cp*ap*tp*cp*cp*cp*g)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'G':
    Compound: DNA/RNA (5'-r(p*cp*gp*gp*gp*a)-d(p*t)-r(p*g)-d(p*t)-r(p*cp*ap*cp*g)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'H':
    Compound: DNA (5'-d(*cp*gp*tp*gp*ap*cp*ap*tp*cp*cp*cp*g)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'I':
    Compound: DNA/RNA (5'-r(p*cp*gp*gp*gp*a)-d(p*t)-r(p*g)-d(p*t)-r(p*cp*ap*cp*g)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'J':
    Compound: DNA (5'-d(*cp*gp*tp*gp*ap*cp*ap*tp*cp*cp*cp*g)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'K':
    Compound: DNA/RNA (5'-r(p*cp*gp*gp*gp*a)-d(p*t)-r(p*g)-d(p*t)-r(p*cp*ap*cp*g)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'L':
    Compound: DNA (5'-d(*cp*gp*tp*gp*ap*cp*ap*tp*cp*cp*cp*g)-3')
    Species: synthetic construct, synthetic [TaxId:32630]
  • Heterogens: MG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6iidA (A:)
mgsshhhhhhssglvprgshmqgaegaltgkqpdgsaekavleqfgfpltgtearcytnh
alsydqakrvprwvlehiskskimgdadrkhckfkpdpnipptfsafnedyvgsgwsrga
mapagnnkfsskamaetfylsnivpqdfdnnsgywnriemycrelterfedvwvvsgplt
lpqtrgdgkkivsyqvigednvavpshlykvilarrssvsteplalgafvvpneaigfqp
qltefqvslqdleklsglvffphldrtsdirnicsvdtcklldfqeftlylstrkiegar
svlrlekimenlknaeiepddyfmsryekkleelkakeqsgtqirkps

    Sequence, based on observed residues (ATOM records):
    >6iidA (A:)
ekavleqfgfpltgtearcytnhalsydqakrvprwvlehiskskimgdadrkhckfkpd
pnipptfsafnedyvgsgwsrgamapagnnkfsskamaetfylsnivpqdfdnnsgywnr
iemycrelterfedvwvvsgpltlpqtrgdgkkivsyqvigednvavpshlykvilarrs
svsteplalgafvvpneaigfqpqltefqvslqdleklsglvffphldrtsdirnicsvd
tcklldfqeftlylstrkiegarsvlrlekimenlknaeiepddyfmsryekklee

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6iidB (B:)
mgsshhhhhhssglvprgshmqgaegaltgkqpdgsaekavleqfgfpltgtearcytnh
alsydqakrvprwvlehiskskimgdadrkhckfkpdpnipptfsafnedyvgsgwsrga
mapagnnkfsskamaetfylsnivpqdfdnnsgywnriemycrelterfedvwvvsgplt
lpqtrgdgkkivsyqvigednvavpshlykvilarrssvsteplalgafvvpneaigfqp
qltefqvslqdleklsglvffphldrtsdirnicsvdtcklldfqeftlylstrkiegar
svlrlekimenlknaeiepddyfmsryekkleelkakeqsgtqirkps

    Sequence, based on observed residues (ATOM records):
    >6iidB (B:)
ekavleqfgfpltgtearcytnhalsydqakrvprwvlehiskskimgdadrkhckfkpd
pnipptfsafnedyvgsgwsrgamapagnnkfsskamaetfylsnivpqdfdnnsgywnr
iemycrelterfedvwvvsgpltlpqtrgdgkkivsyqvigednvavpshlykvilarrs
svsteplalgafvvpneaigfqpqltefqvslqdleklsglvffphldrtsdirnicsvd
tcklldfqeftlylstrkieglekimenlknaeiepddyfmsryekklee

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6iidC (C:)
mgsshhhhhhssglvprgshmqgaegaltgkqpdgsaekavleqfgfpltgtearcytnh
alsydqakrvprwvlehiskskimgdadrkhckfkpdpnipptfsafnedyvgsgwsrga
mapagnnkfsskamaetfylsnivpqdfdnnsgywnriemycrelterfedvwvvsgplt
lpqtrgdgkkivsyqvigednvavpshlykvilarrssvsteplalgafvvpneaigfqp
qltefqvslqdleklsglvffphldrtsdirnicsvdtcklldfqeftlylstrkiegar
svlrlekimenlknaeiepddyfmsryekkleelkakeqsgtqirkps

    Sequence, based on observed residues (ATOM records):
    >6iidC (C:)
kavleqfgfpltgtearcytnhalsydqakrvprwvlehiskskimgdadrkhckfkpdp
nipptfsafnedyvgsgwsrgamapagnnkfsskamaetfylsnivpqdfdnnsgywnri
emycrelterfedvwvvsgpltlpqtrgdgkkivsyqvigednvavpshlykvilarrss
vsteplalgafvvpneaigfqpqltefqvslqdleklsglvffphldrtsdirnicsvdt
cklldfqeftlylstrkiegarsvlrlekimenlknaeiepddyfmsryek

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6iidD (D:)
mgsshhhhhhssglvprgshmqgaegaltgkqpdgsaekavleqfgfpltgtearcytnh
alsydqakrvprwvlehiskskimgdadrkhckfkpdpnipptfsafnedyvgsgwsrga
mapagnnkfsskamaetfylsnivpqdfdnnsgywnriemycrelterfedvwvvsgplt
lpqtrgdgkkivsyqvigednvavpshlykvilarrssvsteplalgafvvpneaigfqp
qltefqvslqdleklsglvffphldrtsdirnicsvdtcklldfqeftlylstrkiegar
svlrlekimenlknaeiepddyfmsryekkleelkakeqsgtqirkps

    Sequence, based on observed residues (ATOM records):
    >6iidD (D:)
aekavleqfgfpltgtearcytnhalsydqakrvprwvlehiskskimgdadrkhckfkp
dpnipptfsafnedyvgsgwsrgamapagnnkfsskamaetfylsnivpqdfdnnsgywn
riemycrelterfedvwvvsgpltlpqtrgdgkkivsyqvigednvavpshlykvilarr
ssvsteplalgafvvpneaigfqpqltefqvslqdleklsglvffphldrtsdirnicsv
dtcklldfqeftlylstrkvlrlekimenlknaeiepddyfmsryekk

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.