PDB entry 6iem

View 6iem on RCSB PDB site
Description: Argininosuccinate lyase from Mycobacterium tuberculosis
Class: lyase
Keywords: arginine biosynthesis, mycobacterium tuberculosis, tetramer, aspartase/fumarase, LYASE
Deposited on 2018-09-14, released 2019-02-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-17, with a file datestamp of 2019-04-12.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Argininosuccinate Lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: argH, Rv1659, MTCY06H11.24
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6iema_
  • Chain 'B':
    Compound: Argininosuccinate Lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: argH, Rv1659, MTCY06H11.24
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6iemb_
  • Chain 'C':
    Compound: Argininosuccinate Lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: argH, Rv1659, MTCY06H11.24
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6iemc_
  • Chain 'D':
    Compound: Argininosuccinate Lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: argH, Rv1659, MTCY06H11.24
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6iemd_
  • Chain 'E':
    Compound: Argininosuccinate Lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: argH, Rv1659, MTCY06H11.24
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ieme_
  • Chain 'F':
    Compound: Argininosuccinate Lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: argH, Rv1659, MTCY06H11.24
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6iemf_
  • Chain 'G':
    Compound: Argininosuccinate Lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: argH, Rv1659, MTCY06H11.24
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6iemg_
  • Chain 'H':
    Compound: Argininosuccinate Lyase
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: argH, Rv1659, MTCY06H11.24
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6iemh_
  • Heterogens: GOL, EDO, PG4, P3G, 2PE, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6iemA (A:)
mstnegslwggrfaggpsdalaalsksthfdwvlapydltasrahtmvlfragllteeqr
dgllagldslaqdvadgsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaa
lfrmwlrdavrrvatgvldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahp
llrdldrivdfdkraavspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfa
aeaafvfamiavdlsrlaediivwsstefgyvtlhdswstgssimpqkknpdiaelargk
sgrlignlagllatlkaqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqr
maelapagytlatdlaewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaisp
eltpqvrevltiegsvsardcrggtapgrvaeqlnaigeaaerlrrqlvr

    Sequence, based on observed residues (ATOM records): (download) 
    >6iemA (A:)
psdalaalsksthfdwvlapydltasrahtmvlfragllteeqrdgllagldslaqdvad
gsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaalfrmwlrdavrrvatg
vldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahpllrdldrivdfdkraa
vspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfaaeaafvfamiavdlsr
laediivwsstefgyvtlhdswstgpqkknpdiaelargksgrlignlagllatlkaqpl
aynrdlqedkepvfdsvaqlelllpamaglvasltfnvqrmaelapagytlatdlaewlv
rqgvpfrsaheaagaavraaeqrgvglqeltddelaaispeltpqvrevltiegsvsard
crggtapgrvaeqlnaigeaaerlrrqlvr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6iemB (B:)
mstnegslwggrfaggpsdalaalsksthfdwvlapydltasrahtmvlfragllteeqr
dgllagldslaqdvadgsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaa
lfrmwlrdavrrvatgvldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahp
llrdldrivdfdkraavspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfa
aeaafvfamiavdlsrlaediivwsstefgyvtlhdswstgssimpqkknpdiaelargk
sgrlignlagllatlkaqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqr
maelapagytlatdlaewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaisp
eltpqvrevltiegsvsardcrggtapgrvaeqlnaigeaaerlrrqlvr

    Sequence, based on observed residues (ATOM records): (download) 
    >6iemB (B:)
slwggrfaggpsdalaalsksthfdwvlapydltasrahtmvlfragllteeqrdgllag
ldslaqdvadgsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaalfrmwl
rdavrrvatgvldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahpllrdld
rivdfdkraavspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfaaeaafv
famiavdlsrlaediivwsstefgyvtlhdswstgimpqkknpdiaelargksgrlignl
agllatlkaqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqrmaelapag
ytlatdlaewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaispeltpqvre
vltiegsvsardcrggtapgrvaeqlnaigeaaerlrrqlvr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6iemC (C:)
mstnegslwggrfaggpsdalaalsksthfdwvlapydltasrahtmvlfragllteeqr
dgllagldslaqdvadgsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaa
lfrmwlrdavrrvatgvldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahp
llrdldrivdfdkraavspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfa
aeaafvfamiavdlsrlaediivwsstefgyvtlhdswstgssimpqkknpdiaelargk
sgrlignlagllatlkaqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqr
maelapagytlatdlaewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaisp
eltpqvrevltiegsvsardcrggtapgrvaeqlnaigeaaerlrrqlvr

    Sequence, based on observed residues (ATOM records): (download) 
    >6iemC (C:)
psdalaalsksthfdwvlapydltasrahtmvlfragllteeqrdgllagldslaqdvad
gsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaalfrmwlrdavrrvatg
vldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahpllrdldrivdfdkraa
vspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfaaeaafvfamiavdlsr
laediivwsstefgyvtlhdswstgpqkknpdiaelargksgrlignlagllatlkaqpl
aynrdlqedkepvfdsvaqlelllpamaglvasltfnvqrmaelapagytlatdlaewlv
rqgvpfrsaheaagaavraaeqrgvglqeltddelaaispeltpqvrevltiegsvsard
crggtapgrvaeqlnaigeaaerlrrqlvr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6iemD (D:)
mstnegslwggrfaggpsdalaalsksthfdwvlapydltasrahtmvlfragllteeqr
dgllagldslaqdvadgsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaa
lfrmwlrdavrrvatgvldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahp
llrdldrivdfdkraavspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfa
aeaafvfamiavdlsrlaediivwsstefgyvtlhdswstgssimpqkknpdiaelargk
sgrlignlagllatlkaqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqr
maelapagytlatdlaewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaisp
eltpqvrevltiegsvsardcrggtapgrvaeqlnaigeaaerlrrqlvr

    Sequence, based on observed residues (ATOM records): (download) 
    >6iemD (D:)
psdalaalsksthfdwvlapydltasrahtmvlfragllteeqrdgllagldslaqdvad
gsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaalfrmwlrdavrrvatg
vldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahpllrdldrivdfdkraa
vspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfaaeaafvfamiavdlsr
laediivwsstefgyvtlhdswstgssimpqkknpdiaelargksgrlignlagllatlk
aqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqrmaelapagytlatdla
ewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaispeltpqvrevltiegsv
sardcrggtapgrvaeqlnaigeaaerlrrqlvr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6iemE (E:)
mstnegslwggrfaggpsdalaalsksthfdwvlapydltasrahtmvlfragllteeqr
dgllagldslaqdvadgsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaa
lfrmwlrdavrrvatgvldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahp
llrdldrivdfdkraavspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfa
aeaafvfamiavdlsrlaediivwsstefgyvtlhdswstgssimpqkknpdiaelargk
sgrlignlagllatlkaqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqr
maelapagytlatdlaewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaisp
eltpqvrevltiegsvsardcrggtapgrvaeqlnaigeaaerlrrqlvr

    Sequence, based on observed residues (ATOM records): (download) 
    >6iemE (E:)
psdalaalsksthfdwvlapydltasrahtmvlfragllteeqrdgllagldslaqdvad
gsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaalfrmwlrdavrrvatg
vldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahpllrdldrivdfdkraa
vspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfaaeaafvfamiavdlsr
laediivwsstefgyvtlhdswstgkknpdiaelargksgrlignlagllatlkaqplay
nrdlqedkepvfdsvaqlelllpamaglvasltfnvqrmaelapagytlatdlaewlvrq
gvpfrsaheaagaavraaeqrgvglqeltddelaaispeltpqvrevltiegsvsardcr
ggtapgrvaeqlnaigeaaerlrrqlvr

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6iemF (F:)
mstnegslwggrfaggpsdalaalsksthfdwvlapydltasrahtmvlfragllteeqr
dgllagldslaqdvadgsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaa
lfrmwlrdavrrvatgvldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahp
llrdldrivdfdkraavspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfa
aeaafvfamiavdlsrlaediivwsstefgyvtlhdswstgssimpqkknpdiaelargk
sgrlignlagllatlkaqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqr
maelapagytlatdlaewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaisp
eltpqvrevltiegsvsardcrggtapgrvaeqlnaigeaaerlrrqlvr

    Sequence, based on observed residues (ATOM records): (download) 
    >6iemF (F:)
psdalaalsksthfdwvlapydltasrahtmvlfragllteeqrdgllagldslaqdvad
gsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaalfrmwlrdavrrvatg
vldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahpllrdldrivdfdkraa
vspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfaaeaafvfamiavdlsr
laediivwsstefgyvtlhdswstgpqkknpdiaelargksgrlignlagllatlkaqpl
aynrdlqedkepvfdsvaqlelllpamaglvasltfnvqrmaelapagytlatdlaewlv
rqgvpfrsaheaagaavraaeqrgvglqeltddelaaispeltpqvrevltiegsvsard
crggtapgrvaeqlnaigeaaerlrrqlvr

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6iemG (G:)
mstnegslwggrfaggpsdalaalsksthfdwvlapydltasrahtmvlfragllteeqr
dgllagldslaqdvadgsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaa
lfrmwlrdavrrvatgvldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahp
llrdldrivdfdkraavspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfa
aeaafvfamiavdlsrlaediivwsstefgyvtlhdswstgssimpqkknpdiaelargk
sgrlignlagllatlkaqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqr
maelapagytlatdlaewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaisp
eltpqvrevltiegsvsardcrggtapgrvaeqlnaigeaaerlrrqlvr

    Sequence, based on observed residues (ATOM records): (download) 
    >6iemG (G:)
psdalaalsksthfdwvlapydltasrahtmvlfragllteeqrdgllagldslaqdvad
gsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaalfrmwlrdavrrvatg
vldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahpllrdldrivdfdkraa
vspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfaaeaafvfamiavdlsr
laediivwsstefgyvtlhdswstgskknpdiaelargksgrlignlagllatlkaqpla
ynrdlqedkepvfdsvaqlelllpamaglvasltfnvqrmaelapagytlatdlaewlvr
qgvpfrsaheaagaavraaeqrgvglqeltddelaaispeltpqvrevltiegsvsardc
rggtapgrvaeqlnaigeaaerlrrqlvr

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6iemH (H:)
mstnegslwggrfaggpsdalaalsksthfdwvlapydltasrahtmvlfragllteeqr
dgllagldslaqdvadgsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaa
lfrmwlrdavrrvatgvldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahp
llrdldrivdfdkraavspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfa
aeaafvfamiavdlsrlaediivwsstefgyvtlhdswstgssimpqkknpdiaelargk
sgrlignlagllatlkaqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqr
maelapagytlatdlaewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaisp
eltpqvrevltiegsvsardcrggtapgrvaeqlnaigeaaerlrrqlvr

    Sequence, based on observed residues (ATOM records): (download) 
    >6iemH (H:)
psdalaalsksthfdwvlapydltasrahtmvlfragllteeqrdgllagldslaqdvad
gsfgplvtdedvhaalerglidrvgpdlggrlragrsrndqvaalfrmwlrdavrrvatg
vldvvgalaeqaaahpsaimpgkthlqsaqpillahhllahahpllrdldrivdfdkraa
vspygsgalagsslgldpdaiaadlgfsaaadnsvdataardfaaeaafvfamiavdlsr
laediivwsstefgyvtlhdswstgssimpqkknpdiaelargksgrlignlagllatlk
aqplaynrdlqedkepvfdsvaqlelllpamaglvasltfnvqrmaelapagytlatdla
ewlvrqgvpfrsaheaagaavraaeqrgvglqeltddelaaispeltpqvrevltiegsv
sardcrggtapgrvaeqlnaigeaaerlrrqlvr