PDB entry 6i99

View 6i99 on RCSB PDB site
Description: bone marrow tyrosine kinase in chromosome x in complex with a newly designed covalent inhibitor js24
Deposited on 2018-11-22, released 2020-05-27
The last revision was dated 2020-11-04, with a file datestamp of 2020-10-30.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytoplasmic tyrosine-protein kinase BMX
    Species: Homo sapiens [TaxId:9606]
    Gene: BMX
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51813 (13-End)
      • expression tag (8-12)
      • engineered mutation (34)
      • engineered mutation (213)
      • engineered mutation (219)
      • engineered mutation (222)
  • Chain 'B':
    Compound: Cytoplasmic tyrosine-protein kinase BMX
    Species: Homo sapiens [TaxId:9606]
    Gene: BMX
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51813 (13-End)
      • engineered mutation (34)
      • engineered mutation (213)
      • engineered mutation (219)
      • engineered mutation (222)
  • Heterogens: H88, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6i99A (A:)
hhhhhhenlyfqgelkreeitllkelgsgqfgvvklgkwkgqydvavkmikegsmsedef
fqeaqtmmklshpklvkfygvcskeypiyivteyisngcllnylrshgkglepsqllemc
ydvcegmafleshqfihrdlaarnclvdrdlcvkvsdfgmtryvlddqyvssvgtkfpvk
wsapevfhyfkyssksdvwafgilmwevfslgkmpydlytnsevvlkvsqghrlyrphla
sdtiyqimyscwhelpekrptfqqllssieplrekdkh

    Sequence, based on observed residues (ATOM records):
    >6i99A (A:)
lyfqgelkreeitllkelgsgqfgvvklgkwkgqydvavkmikegsmsedeffqeaqtmm
klshpklvkfygvcskeypiyivteyisngcllnylrshgkglepsqllemcydvcegma
fleshqfihrdlaarnclvdrdlcvkvsdfgmtryvlddqyvssvgtkfpvkwsapevfh
yfkyssksdvwafgilmwevfslgkmpydlytnsevvlkvsqghrlyrphlasdtiyqim
yscwhelpekrptfqqllssieplre

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6i99B (B:)
hhhhhhenlyfqgelkreeitllkelgsgqfgvvklgkwkgqydvavkmikegsmsedef
fqeaqtmmklshpklvkfygvcskeypiyivteyisngcllnylrshgkglepsqllemc
ydvcegmafleshqfihrdlaarnclvdrdlcvkvsdfgmtryvlddqyvssvgtkfpvk
wsapevfhyfkyssksdvwafgilmwevfslgkmpydlytnsevvlkvsqghrlyrphla
sdtiyqimyscwhelpekrptfqqllssieplrekdkh

    Sequence, based on observed residues (ATOM records):
    >6i99B (B:)
elkreeitllkelgsgqfgvvklgkwkgqydvavkmikegsmsedeffqeaqtmmklshp
klvkfygvcskeypiyivteyisngcllnylrshgkglepsqllemcydvcegmaflesh
qfihrdlaarnclvdrdlcvkvsdfgmtryvlddqyvssvgtkfpvkwsapevfhyfkys
sksdvwafgilmwevfslgkmpydlytnsevvlkvsqghrlyrphlasdtiyqimyscwh
elpekrptfqqllssieplre