PDB entry 6i8t

View 6i8t on RCSB PDB site
Description: the catalytic fragment of poly(ADP-ribose) polymerase complexed with an isoindolinone inhibitor
Class: transferase
Keywords: transferase, chicken parp1, inhibitor complex, ADP-ribosylation, DNA damage
Deposited on 2018-11-21, released 2019-05-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-01, with a file datestamp of 2019-04-26.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Poly [ADP-ribose] polymerase 1
    Species: Gallus gallus [TaxId:9031]
    Gene: Parp1, Adprt
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6i8ta1, d6i8ta2
  • Heterogens: H7Z, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6i8tA (A:)
gpkltvsagtksklakpiqdlikmifdvesmkkamvefeidlqkmplgklskrqiqsays
ilnevqqavsdggsesqildlsnrfytliphdfgmkkppllsnleyiqakvqmldnlldi
evaysllrggnedgdkdpidinyeklrtdikvvdkdseeakiikqyvknthaathnaydl
kvveifrieregesqrykpfkqlhnrqllwhgsrttnfagilsqglriappeapvtgymf
gkgiyfadmvsksanychtsqadpiglillgevalgnmyelknashitklpkgkhsvkgl
gktapdptatttldgvevplgngistgindtcllyneyivydvaqvnlkyllklkfnykt
slw

    Sequence, based on observed residues (ATOM records): (download) 
    >6i8tA (A:)
ksklakpiqdlikmifdvesmkkamvefeidlqkmplgklskrqiqsaysilnevqqavs
dggsesqildlsnrfytliphdfgmkkppllsnleyiqakvqmldnlldievaysllrgg
nedgdkdpidinyeklrtdikvvdkdseeakiikqyvknthaathnaydlkvveifrier
egesqrykpfkqlhnrqllwhgsrttnfagilsqglriappeapvtgymfgkgiyfadmv
sksanychtsqadpiglillgevalgnmyelknashitklpkgkhsvkglgktapdptat
ttldgvevplgngistgindtcllyneyivydvaqvnlkyllklkfny