SCOPe 2.08: Structural Classification of Proteins

PDB entry 6i8s

View 6i8s on RCSB PDB site
Description: Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
Class: blood clotting
Keywords: serpin, plasminogen activator inhibitor-1, pai-1, antibody, fab, blood clotting
Deposited on 2018-11-21, released 2019-02-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-13, with a file datestamp of 2019-11-08.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Plasminogen activator inhibitor 1
Species: Homo sapiens [TaxId:9606]
Gene: SERPINE1, PAI1, PLANH1
Database cross-references and differences (RAF-indexed):
- Uniprot P05121 (Start-378)
  - engineered mutation (149)
  - engineered mutation (153)
  - engineered mutation (318)
  - engineered mutation (353)
Domains in SCOPe 2.08: d6i8sa_
Chain 'B':
Compound: Plasminogen activator inhibitor 1
Species: Homo sapiens [TaxId:9606]
Gene: SERPINE1, PAI1, PLANH1
Database cross-references and differences (RAF-indexed):
- Uniprot P05121 (Start-378)
  - engineered mutation (149)
  - engineered mutation (153)
  - engineered mutation (318)
  - engineered mutation (353)
Domains in SCOPe 2.08: d6i8sb_
Chain 'C':
Compound: Plasminogen activator inhibitor 1
Species: Homo sapiens [TaxId:9606]
Gene: SERPINE1, PAI1, PLANH1
Database cross-references and differences (RAF-indexed):
- Uniprot P05121 (Start-378)
  - engineered mutation (149)
  - engineered mutation (153)
  - engineered mutation (318)
  - engineered mutation (353)
Domains in SCOPe 2.08: d6i8sc_
Chain 'D':
Compound: Plasminogen activator inhibitor 1
Species: Homo sapiens [TaxId:9606]
Gene: SERPINE1, PAI1, PLANH1
Database cross-references and differences (RAF-indexed):
- Uniprot P05121 (Start-378)
  - engineered mutation (149)
  - engineered mutation (153)
  - engineered mutation (318)
  - engineered mutation (353)
Domains in SCOPe 2.08: d6i8sd_
Chain 'E':
Compound: heavy chain of fab fragment from an pai-1 antibody
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6I8S (0-End)
Domains in SCOPe 2.08: d6i8se_
Chain 'F':
Compound: heavy chain of fab fragment from an pai-1 antibody
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6I8S (0-End)
Domains in SCOPe 2.08: d6i8sf_
Chain 'G':
Compound: heavy chain of fab fragment from an pai-1 antibody
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6I8S (0-End)
Domains in SCOPe 2.08: d6i8sg_
Chain 'H':
Compound: heavy chain of fab fragment from an pai-1 antibody
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6I8S (0-End)
Domains in SCOPe 2.08: d6i8sh_
Chain 'I':
Compound: light chain of fab fragment from an pai-1 antibody
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6I8S (0-End)
Domains in SCOPe 2.08: d6i8si1, d6i8si2
Chain 'J':
Compound: light chain of fab fragment from an pai-1 antibody
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6I8S (0-End)
Domains in SCOPe 2.08: d6i8sj1, d6i8sj2
Chain 'K':
Compound: light chain of fab fragment from an pai-1 antibody
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6I8S (0-End)
Domains in SCOPe 2.08: d6i8sk1, d6i8sk2
Chain 'L':
Compound: light chain of fab fragment from an pai-1 antibody
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 6I8S (0-End)
Domains in SCOPe 2.08: d6i8sl1, d6i8sl2
Heterogens: HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>6i8sA (A:)
vhhppsyvahlasdfgvrvfqqvaqaskdrnvvfspygvasvlamlqlttggetqqqiqa
amgfkiddkgmapalrhlykelmgpwnkdeisttdaifvqrdlklvqgfmphffrlfrst
vkqvdfseverarfiindwvkthtkgmishllgtgavdqltrlvlvnalyfngqwktpfp
dssthrrlfhksdgstvsvpmmaqtnkfnytefttpdghyydilelpyhgdtlsmfiaap
yekevplsaltnilsaqlishwkgnmtrlprllvlpkfsletevdlrkplenlgmtdmfr
qfqadftslsdqeplhvalalqkvkievnesgtvassstavivsarmapeeiiidrpflf
vvrhnptgtvlfmgqvmep