PDB entry 6i8a

View 6i8a on RCSB PDB site
Description: the crystal structure of the pol2 catalytic domain of dna polymerase epsilon carrying a p301r substitution.
Deposited on 2018-11-19, released 2019-01-30
The last revision was dated 2019-02-06, with a file datestamp of 2019-02-01.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA polymerase epsilon catalytic subunit A
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: POL2, DUN2, YNL262W, N0825
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21951 (Start-1189)
      • engineered mutation (305)
  • Chain 'B':
    Compound: DNA polymerase epsilon catalytic subunit A
    Species: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) [TaxId:559292]
    Gene: POL2, DUN2, YNL262W, N0825
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21951 (Start-1189)
      • engineered mutation (305)
  • Chain 'C':
    Compound: Primer DNA
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'D':
    Compound: Template DNA
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'P':
    Compound: Primer DNA
    Species: synthetic construct, synthetic [TaxId:32630]
  • Chain 'T':
    Compound: Template DNA
    Species: synthetic construct, synthetic [TaxId:32630]
  • Heterogens: DTP, CA, FE, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6i8aA (A:)
    ggdphmmfgkkknnggsstarysagnkyntlsnnyalsaqqllnaskiddidsmmgfery
    vppqyngrfdakdidqipgrvgwltnmhatlvsqetlssgsngggnsndgervttnqgis
    gvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirkedl
    tmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvaangsekvda
    khliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettk
    pplkfrdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnende
    vallqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykss
    ycshmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysv
    sdavatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkh
    tdpierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfs
    vevenkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasmypnimttnrlq
    pdsikaerdcascdfnrpgktcarklkwawrgeffpskmdeynmikralqnetfpnknkf
    skkkvltfdelsyadqvihikkrlteysrkvyhrvkvseivereaivcqrenpfyvdtvk
    sfrdrryefkglaktwkgnlskidpsdkhardeakkmivlydslqlahkvilnsfygyvm
    rkgsrwysmemagitcltgatiiqmaralvervgrpleldtdgiwcilpksfpetyfftl
    engkklylsypcsmlnyrvhqkftnhqyqelkdplnyiyethsentiffevdgpykamil
    psskeegkgikkryavfnedgslaelkgfelkrrgelqliknfqsdifkvflegdtlegc
    ysavasvcnrwldvldshglmlededlvslicenrsmsktlkeyegqkstsittarrlgd
    flgedmvkdkglqckyiisskpfnapvteraipvaifsadipikrsflrrwtldpsledl
    dirtiidwgyyrerlgsaiqkiitipaalqgvsnpvprvehpdwlkrkia
    

    Sequence, based on observed residues (ATOM records):
    >6i8aA (A:)
    alsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqe
    nqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqii
    rkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvdakhl
    iedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettkppl
    kfrdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnendeval
    lqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykssycs
    hmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysvsda
    vatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkhtdp
    ierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfsvev
    enkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasmypnimttnrlqpds
    ikaetcarklkwawrgeffpskmdeynmikralqnetfpnknltfdelsyadqvihikkr
    lteysrkvyhrvkvseivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlski
    dpsdkhardeakkmivlydslqlahkvilnsfygyvmrkgsrwysmemagitcltgatii
    qmaralvervgrpleldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkf
    tnhqyqelkdplnyiyethsentiffevdgpykamilpsskeegkgikkryavfnedgsl
    aelkgfelkrrgelqliknfqsdifkvflegdtlegcysavasvcnrwldvldshglmle
    dedlvslicenrsmsktlkeyegqkstsittarrlgdflgedmvkdkglqckyiisskpf
    napvteraipvaifsadipikrsflrrwtldpsledldirtiidwgyyrerlgsaiqkii
    tipaalqgvsnpvprvehpdwlkrkia
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6i8aB (B:)
    ggdphmmfgkkknnggsstarysagnkyntlsnnyalsaqqllnaskiddidsmmgfery
    vppqyngrfdakdidqipgrvgwltnmhatlvsqetlssgsngggnsndgervttnqgis
    gvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirkedl
    tmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvaangsekvda
    khliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettk
    pplkfrdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnende
    vallqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykss
    ycshmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysv
    sdavatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkh
    tdpierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfs
    vevenkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasmypnimttnrlq
    pdsikaerdcascdfnrpgktcarklkwawrgeffpskmdeynmikralqnetfpnknkf
    skkkvltfdelsyadqvihikkrlteysrkvyhrvkvseivereaivcqrenpfyvdtvk
    sfrdrryefkglaktwkgnlskidpsdkhardeakkmivlydslqlahkvilnsfygyvm
    rkgsrwysmemagitcltgatiiqmaralvervgrpleldtdgiwcilpksfpetyfftl
    engkklylsypcsmlnyrvhqkftnhqyqelkdplnyiyethsentiffevdgpykamil
    psskeegkgikkryavfnedgslaelkgfelkrrgelqliknfqsdifkvflegdtlegc
    ysavasvcnrwldvldshglmlededlvslicenrsmsktlkeyegqkstsittarrlgd
    flgedmvkdkglqckyiisskpfnapvteraipvaifsadipikrsflrrwtldpsledl
    dirtiidwgyyrerlgsaiqkiitipaalqgvsnpvprvehpdwlkrkia
    

    Sequence, based on observed residues (ATOM records):
    >6i8aB (B:)
    nyalsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvs
    qqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqii
    rkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvdakhl
    iedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettkppl
    kfrdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnendeval
    lqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykssycs
    hmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysvsda
    vatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkhtdp
    ierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfsvev
    enkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasmypnimttnrlqpds
    iktcarklkwawrgeffpskmdeynmikralqnetfpnktfdelsyadqvihikkrltey
    vseivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlskidpsdkhardeakk
    mivlydslqlahkvilnsfygyvmrkgsrwysmemagitcltgatiiqmaralvervgrp
    leldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkftnhqyqelkdpln
    yiyethsentiffevdgpykamilpsskeegkgikkryavfnedgslaelkgfelkrrge
    lqliknfqsdifkvflegdtlegcysavasvcnrwldvldshglmlededlvslicenrs
    msktlkeyegqkstsittarrlgdflgedmvkdkglqckyiisskpfnapvteraipvai
    fsadipikrsflrrwtldpsledldirtiidwgyyrerlgsaiqkiitipaalqgvsnpv
    prvehpdwlkrkia
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'P':
    No sequence available.

  • Chain 'T':
    No sequence available.