PDB entry 6i83

View 6i83 on RCSB PDB site
Description: Crystal structure of phosphorylated RET V804M tyrosine kinase domain complexed with PDD00018366
Class: oncoprotein
Keywords: inhibitor, kinase, proto-oncogene, ONCOPROTEIN
Deposited on 2018-11-19, released 2020-03-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-22, with a file datestamp of 2020-04-17.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07949 (5-313)
      • expression tag (0-4)
      • engineered mutation (104)
    Domains in SCOPe 2.08: d6i83a1, d6i83a2
  • Heterogens: H72, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6i83A (A:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgplllimeyakygslrgflres
rkvgpgylgsggsrnsssldhpderaltmgdlisfawqisqgmqylaemklvhrdlaarn
ilvaegrkmkisdfglsrdvyeedsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgv
llweivtlggnpypgipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfa
diskdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >6i83A (A:)
gplslsvdafkiledpkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgplllimeyakygslrgflres
rkraltmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfglsrdvye
edsyvkrsqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypgipperlf
nllktghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkrr