PDB entry 6i7u

View 6i7u on RCSB PDB site
Description: Alpha-1-antitrypsin (Ala250Met) in the native conformation
Class: protein binding
Keywords: Antitrypsin, protease inhibitor, serpin, mutant, deficiency, PROTEIN BINDING, breach region
Deposited on 2018-11-19, released 2019-11-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-11-27, with a file datestamp of 2019-11-22.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha-1-antitrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA1, AAT, PI, PRO0684, PRO2209
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01009 (Start-403)
      • engineered mutation (259)
    Domains in SCOPe 2.08: d6i7ua_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6i7uA (A:)
mrgshhhhhhtdpqgdaaqktdtshhdqdhptfnkitpnlaefafslyrqlahqsnstni
ffspvsiatafamlslgtkadthdeileglnfnlteipeaqihegfqellrtlnqpdsql
qlttgnglflseglklvdkfledvkklyhseaftvnfgdteeakkqindyvekgtqgkiv
dlvkeldrdtvfalvnyiffkgkwerpfevkdteeedfhvdqvttvkvpmmkrlgmfniq
hckklsswvllmkylgnatmifflpdegklqhlenelthdiitkflenedrrsaslhlpk
lsitgtydlksvlgqlgitkvfsngadlsgvteeaplklskavhkavltidekgteaaga
mfleaipmsippevkfnkpfvflmieqntksplfmgkvvnptqk

    Sequence, based on observed residues (ATOM records): (download) 
    >6i7uA (A:)
fnkitpnlaefafslyrqlahqsnstniffspvsiatafamlslgtkadthdeileglnf
nlteipeaqihegfqellrtlnqpdsqlqlttgnglflseglklvdkfledvkklyhsea
ftvnfgdteeakkqindyvekgtqgkivdlvkeldrdtvfalvnyiffkgkwerpfevkd
teeedfhvdqvttvkvpmmkrlgmfniqhckklsswvllmkylgnatmifflpdegklqh
lenelthdiitkflenedrrsaslhlpklsitgtydlksvlgqlgitkvfsngadlsgvt
eeaplklskavhkavltidekgteaagamfleaipmsippevkfnkpfvflmieqntksp
lfmgkvvnptqk