PDB entry 6i7q

View 6i7q on RCSB PDB site
Description: structure of pvhl-elongin b-elongin c (vcb) in complex with hydroxylated-hif-2alpha (523-542) in the c2221 form
Deposited on 2018-11-17, released 2019-11-27
The last revision was dated 2021-01-20, with a file datestamp of 2021-01-15.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: Elongin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOB, TCEB2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Elongin-C
    Species: Bos taurus [TaxId:9913]
    Gene: ELOC, TCEB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q2KII4 (1-96)
      • expression tag (0)
  • Chain 'H':
    Compound: Endothelial PAS domain-containing protein 1
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99814 (Start-19)
      • conflict (19)
  • Chain 'V':
    Compound: von hippel-lindau disease tumor suppressor
    Species: Homo sapiens [TaxId:9606]
    Gene: VHL
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6i7qB (B:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmkpqdsgssaneqavq

    Sequence, based on observed residues (ATOM records):
    >6i7qB (B:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmkp

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6i7qC (C:)
smyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6i7qH (H:)
eldletlapyipmdgedfqc

    Sequence, based on observed residues (ATOM records):
    >6i7qH (H:)
letlapyipmdgedfqc

  • Chain 'V':
    Sequence, based on SEQRES records:
    >6i7qV (V:)
meagrprpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyr
ghlwlfrdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpe
nyrrldivrslyedledhpnvqkdlerltqeriahqrmgd

    Sequence, based on observed residues (ATOM records):
    >6i7qV (V:)
rpvlrsvnsrepsqvifcnrsprvvlpvwlnfdgepqpyptlppgtgrrihsyrghlwlf
rdagthdgllvnqtelfvpslnvdgqpifanitlpvytlkerclqvvrslvkpenyrrld
ivrslyedledhpnvqkdlerltqeriahqr