PDB entry 6i7a

View 6i7a on RCSB PDB site
Description: Co-crystal structure of human SPOP MATH domain (D140N) and human BRD3 fragment
Class: ligase
Keywords: ligase nuclear cancer ubiquitination, LIGASE
Deposited on 2018-11-16, released 2019-05-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-15, with a file datestamp of 2020-01-10.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Speckle-type POZ protein
    Species: Homo sapiens [TaxId:9606]
    Gene: SPOP
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43791 (6-144)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d6i7aa_
  • Chain 'B':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Speckle-type POZ protein
    Species: Homo sapiens [TaxId:9606]
    Gene: SPOP
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43791 (6-144)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d6i7ac_
  • Chain 'D':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Speckle-type POZ protein
    Species: Homo sapiens [TaxId:9606]
    Gene: SPOP
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43791 (6-144)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d6i7ae_
  • Chain 'F':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Speckle-type POZ protein
    Species: Homo sapiens [TaxId:9606]
    Gene: SPOP
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43791 (6-144)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d6i7ag_
  • Chain 'H':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6i7aA (A:)
gamasgkvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeesk
dylslylllvscpksevrakfkfsilnakgeetkamesqrayrfvqgkdwgfkkfirrnf
lldeangllpddkltlfcevsvvqd

    Sequence, based on observed residues (ATOM records): (download) 
    >6i7aA (A:)
kvvkfsymwtinnfsfcreemgeviksstfssndklkwclrvnpkgldeeskdylslyll
lvscpksevrakfkfsilnakgeetkamesqrayrfvqgkdwgfkkfirrnflldeangl
lpddkltlfcevsvvqd

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6i7aC (C:)
gamasgkvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeesk
dylslylllvscpksevrakfkfsilnakgeetkamesqrayrfvqgkdwgfkkfirrnf
lldeangllpddkltlfcevsvvqd

    Sequence, based on observed residues (ATOM records): (download) 
    >6i7aC (C:)
kvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeeskdylsly
lllvscpksevrakfkfsilnakgeetkamesqrayrfvqgkdwgfkkfirrnflldean
gllpddkltlfcevsvvqd

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6i7aE (E:)
gamasgkvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeesk
dylslylllvscpksevrakfkfsilnakgeetkamesqrayrfvqgkdwgfkkfirrnf
lldeangllpddkltlfcevsvvqd

    Sequence, based on observed residues (ATOM records): (download) 
    >6i7aE (E:)
kvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeeskdylsly
lllvscpksevrakfkfsilnakgeetkamesqrayrfvqgkdwgfkkfirrnflldean
gllpddkltlfcevsvvqd

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6i7aG (G:)
gamasgkvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeesk
dylslylllvscpksevrakfkfsilnakgeetkamesqrayrfvqgkdwgfkkfirrnf
lldeangllpddkltlfcevsvvqd

    Sequence, based on observed residues (ATOM records): (download) 
    >6i7aG (G:)
kvvkfsymwtinnfsfcremgeviksstfssgandklkwclrvnpkgldeeskdylslyl
llvscpksevrakfkfsilnakgeetkamesqrayrfvqgkdwgfkkfirrnflldeang
llpddkltlfcevsvvqd

  • Chain 'H':
    No sequence available.