PDB entry 6i68

View 6i68 on RCSB PDB site
Description: Co-crystal structure of human SPOP MATH domain (M117V) and human BRD3 fragment
Class: ligase
Keywords: ligase nuclear cancer ubiquitination, LIGASE
Deposited on 2018-11-15, released 2019-05-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-15, with a file datestamp of 2020-01-10.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Speckle-type POZ protein
    Species: Homo sapiens [TaxId:9606]
    Gene: SPOP
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43791 (6-144)
      • expression tag (4-5)
      • engineered mutation (95)
    Domains in SCOPe 2.08: d6i68a1, d6i68a2
  • Chain 'B':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Speckle-type POZ protein
    Species: Homo sapiens [TaxId:9606]
    Gene: SPOP
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43791 (6-144)
      • engineered mutation (95)
    Domains in SCOPe 2.08: d6i68c_
  • Chain 'D':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Speckle-type POZ protein
    Species: Homo sapiens [TaxId:9606]
    Gene: SPOP
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43791 (6-144)
      • engineered mutation (95)
    Domains in SCOPe 2.08: d6i68e_
  • Chain 'F':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Speckle-type POZ protein
    Species: Homo sapiens [TaxId:9606]
    Gene: SPOP
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43791 (6-End)
      • engineered mutation (95)
    Domains in SCOPe 2.08: d6i68g_
  • Chain 'H':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6i68A (A:)
gamasgkvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeesk
dylslylllvscpksevrakfkfsilnakgeetkavesqrayrfvqgkdwgfkkfirrdf
lldeangllpddkltlfcevsvvqd

    Sequence, based on observed residues (ATOM records): (download) 
    >6i68A (A:)
sgkvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeeskdyls
lylllvscpksevrakfkfsilnakgeetkavesqrayrfvqgkdwgfkkfirrdfllde
angllpddkltlfcevsvvqd

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6i68C (C:)
gamasgkvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeesk
dylslylllvscpksevrakfkfsilnakgeetkavesqrayrfvqgkdwgfkkfirrdf
lldeangllpddkltlfcevsvvqd

    Sequence, based on observed residues (ATOM records): (download) 
    >6i68C (C:)
kvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeeskdylsly
lllvscpksevrakfkfsilnakgeetkavesqrayrfvqgkdwgfkkfirrdflldean
gllpddkltlfcevsvvqd

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6i68E (E:)
gamasgkvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeesk
dylslylllvscpksevrakfkfsilnakgeetkavesqrayrfvqgkdwgfkkfirrdf
lldeangllpddkltlfcevsvvqd

    Sequence, based on observed residues (ATOM records): (download) 
    >6i68E (E:)
kvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeeskdylsly
lllvscpksevrakfkfsilnakgeetkavesqrayrfvqgkdwgfkkfirrdflldean
gllpddkltlfcevsvvqd

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6i68G (G:)
gamasgkvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeesk
dylslylllvscpksevrakfkfsilnakgeetkavesqrayrfvqgkdwgfkkfirrdf
lldeangllpddkltlfcevsvvqd

    Sequence, based on observed residues (ATOM records): (download) 
    >6i68G (G:)
kvvkfsymwtinnfsfcreemgeviksstfssgandklkwclrvnpkgldeeskdylsly
lllvscpksevrakfkfsilnakgeetkavesqrayrfvqgkdwgfkkfirrdflldean
gllpddkltlfcevsvv

  • Chain 'H':
    No sequence available.