PDB entry 6i5j

View 6i5j on RCSB PDB site
Description: crystal structure of socs2:elongin c:elongin b in complex with growth hormone receptor peptide
Deposited on 2018-11-13, released 2019-05-29
The last revision was dated 2019-11-20, with a file datestamp of 2019-11-15.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: suppressor of cytokine signaling 2
    Species: Homo sapiens [TaxId:9606]
    Gene: SOCS2, CIS2, SSI2, STATI2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14508 (0-168)
      • engineered mutation (1)
  • Chain 'B':
    Compound: Elongin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOB, TCEB2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Elongin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOC, TCEB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15369 (1-96)
      • initiating methionine (0)
  • Chain 'D':
    Compound: suppressor of cytokine signaling 2
    Species: Homo sapiens [TaxId:9606]
    Gene: SOCS2, CIS2, SSI2, STATI2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14508 (0-168)
      • engineered mutation (1)
  • Chain 'E':
    Compound: Elongin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOB, TCEB2
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Elongin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: ELOC, TCEB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15369 (1-96)
      • initiating methionine (0)
  • Chain 'I':
    Compound: Growth hormone receptor peptide
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6I5J (0-10)
  • Chain 'J':
    Compound: Growth hormone receptor peptide
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6I5J (0-End)
  • Chain 'K':
    Compound: Growth hormone receptor peptide
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6I5J (Start-10)
  • Chain 'L':
    Compound: Growth hormone receptor peptide
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6I5J (Start-10)
  • Heterogens: CO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6i5jA (A:)
smqaarlakalrelgqtgwywgsmtvneakeklkeapegtflirdsshsdylltisvkts
agptnlrieyqdgkfrldsiicvksklkqfdsvvhlidyyvqmckdkrtgpeaprngtvh
lyltkplytsapslqhlcrltinkctgaiwglplptrlkdyleeykfqv

    Sequence, based on observed residues (ATOM records):
    >6i5jA (A:)
smqaarlakalrelgqtgwywgsmtvneakeklkeapegtflirdsshsdylltisvkts
agptnlrieyqdgkfrldsiicvksklkqfdsvvhlidyyvqmckdkrgpeaprngtvhl
yltkplytsapslqhlcrltinkctgaiwglplptrlkdyleeykfqv

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6i5jB (B:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6i5jC (C:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >6i5jD (D:)
smqaarlakalrelgqtgwywgsmtvneakeklkeapegtflirdsshsdylltisvkts
agptnlrieyqdgkfrldsiicvksklkqfdsvvhlidyyvqmckdkrtgpeaprngtvh
lyltkplytsapslqhlcrltinkctgaiwglplptrlkdyleeykfqv

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6i5jE (E:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvmk

    Sequence, based on observed residues (ATOM records):
    >6i5jE (E:)
mdvflmirrhkttiftdakesstvfelkrivegilkrppdeqrlykddqllddgktlgec
gftsqtarpqapatvglafraddtfealciepfssppelpdvm

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records:
    >6i5jF (F:)
mmyvklissdghefivkrehaltsgtikamlsgpgqfaenetnevnfreipshvlskvcm
yftykvrytnssteipefpiapeialellmaanfldc

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records:
    >6i5jI (I:)
pvpdytsihix

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6i5jJ (J:)
pvpdytsihix

    Sequence, based on observed residues (ATOM records):
    >6i5jJ (J:)
pvpdytsihi

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6i5jK (K:)
pvpdytsihix

    Sequence, based on observed residues (ATOM records):
    >6i5jK (K:)
vpdytsihix

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6i5jL (L:)
pvpdytsihix

    Sequence, based on observed residues (ATOM records):
    >6i5jL (L:)
pdytsihix