PDB entry 6i4u

View 6i4u on RCSB PDB site
Description: crystal structure of the disease-causing g426e mutant of the human dihydrolipoamide dehydrogenase
Deposited on 2018-11-10, released 2019-11-20
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydrolipoyl dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DLD, GCSL, LAD, PHE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09622 (Start-495)
      • engineered mutation (447)
  • Chain 'B':
    Compound: Dihydrolipoyl dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DLD, GCSL, LAD, PHE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09622 (22-495)
      • expression tag (14-21)
      • engineered mutation (447)
  • Heterogens: FAD, SO4, 1PE, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6i4uA (A:)
maswshpqfekgalevlfqgpgadqpidadvtvigsgpggyvaaikaaqlgfktvciekn
etlggtclnvgcipskallnnshyyhmahgkdfasrgiemsevrlnldkmmeqkstavka
ltggiahlfkqnkvvhvngygkitgknqvtatkadggtqvidtkniliatgsevtpfpgi
tidedtivsstgalslkkvpekmvvigagvigvelgsvwqrlgadvtaveflghvggvgi
dmeisknfqrilqkqgfkfklntkvtgatkksdgkidvsieaasggkaevitcdvllvci
grrpftknlgleelgieldprgripvntrfqtkipniyaigdvvagpmlahkaedegiic
vegmaggavhidyncvpsviythpevawvgkseeqlkeegieykvgkfpfaansraktna
dtdgmvkilgqkstdrvlgahilgpgaeemvneaalaleygascediarvchahptlsea
freanlaasfgksinf

    Sequence, based on observed residues (ATOM records):
    >6i4uA (A:)
qpidadvtvigsgpggyvaaikaaqlgfktvcieknetlggtclnvgcipskallnnshy
yhmahgkdfasrgiemsevrlnldkmmeqkstavkaltggiahlfkqnkvvhvngygkit
gknqvtatkadggtqvidtkniliatgsevtpfpgitidedtivsstgalslkkvpekmv
vigagvigvelgsvwqrlgadvtaveflghvggvgidmeisknfqrilqkqgfkfklntk
vtgatkksdgkidvsieaasggkaevitcdvllvcigrrpftknlgleelgieldprgri
pvntrfqtkipniyaigdvvagpmlahkaedegiicvegmaggavhidyncvpsviythp
evawvgkseeqlkeegieykvgkfpfaansraktnadtdgmvkilgqkstdrvlgahilg
pgaeemvneaalaleygascediarvchahptlseafreanlaasfgksinf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6i4uB (B:)
maswshpqfekgalevlfqgpgadqpidadvtvigsgpggyvaaikaaqlgfktvciekn
etlggtclnvgcipskallnnshyyhmahgkdfasrgiemsevrlnldkmmeqkstavka
ltggiahlfkqnkvvhvngygkitgknqvtatkadggtqvidtkniliatgsevtpfpgi
tidedtivsstgalslkkvpekmvvigagvigvelgsvwqrlgadvtaveflghvggvgi
dmeisknfqrilqkqgfkfklntkvtgatkksdgkidvsieaasggkaevitcdvllvci
grrpftknlgleelgieldprgripvntrfqtkipniyaigdvvagpmlahkaedegiic
vegmaggavhidyncvpsviythpevawvgkseeqlkeegieykvgkfpfaansraktna
dtdgmvkilgqkstdrvlgahilgpgaeemvneaalaleygascediarvchahptlsea
freanlaasfgksinf

    Sequence, based on observed residues (ATOM records):
    >6i4uB (B:)
evlfqgpgadqpidadvtvigsgpggyvaaikaaqlgfktvcieknetlggtclnvgcip
skallnnshyyhmahgkdfasrgiemsevrlnldkmmeqkstavkaltggiahlfkqnkv
vhvngygkitgknqvtatkadggtqvidtkniliatgsevtpfpgitidedtivsstgal
slkkvpekmvvigagvigvelgsvwqrlgadvtaveflghvggvgidmeisknfqrilqk
qgfkfklntkvtgatkksdgkidvsieaasggkaevitcdvllvcigrrpftknlgleel
gieldprgripvntrfqtkipniyaigdvvagpmlahkaedegiicvegmaggavhidyn
cvpsviythpevawvgkseeqlkeegieykvgkfpfaansraktnadtdgmvkilgqkst
drvlgahilgpgaeemvneaalaleygascediarvchahptlseafreanlaasfgksi
nf