PDB entry 6i4s

View 6i4s on RCSB PDB site
Description: crystal structure of the disease-causing r447g mutant of the human dihydrolipoamide dehydrogenase
Deposited on 2018-11-10, released 2019-11-20
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydrolipoyl dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DLD, GCSL, LAD, PHE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09622 (Start-495)
      • engineered mutation (468)
  • Chain 'B':
    Compound: Dihydrolipoyl dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DLD, GCSL, LAD, PHE3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09622 (22-495)
      • expression tag (15-21)
      • engineered mutation (468)
  • Heterogens: FAD, SO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6i4sA (A:)
maswshpqfekgalevlfqgpgadqpidadvtvigsgpggyvaaikaaqlgfktvciekn
etlggtclnvgcipskallnnshyyhmahgkdfasrgiemsevrlnldkmmeqkstavka
ltggiahlfkqnkvvhvngygkitgknqvtatkadggtqvidtkniliatgsevtpfpgi
tidedtivsstgalslkkvpekmvvigagvigvelgsvwqrlgadvtaveflghvggvgi
dmeisknfqrilqkqgfkfklntkvtgatkksdgkidvsieaasggkaevitcdvllvci
grrpftknlgleelgieldprgripvntrfqtkipniyaigdvvagpmlahkaedegiic
vegmaggavhidyncvpsviythpevawvgkseeqlkeegieykvgkfpfaansraktna
dtdgmvkilgqkstdrvlgahilgpgagemvneaalaleygascediagvchahptlsea
freanlaasfgksinf

    Sequence, based on observed residues (ATOM records):
    >6i4sA (A:)
qpidadvtvigsgpggyvaaikaaqlgfktvcieknetlggtclnvgcipskallnnshy
yhmahgkdfasrgiemsevrlnldkmmeqkstavkaltggiahlfkqnkvvhvngygkit
gknqvtatkadggtqvidtkniliatgsevtpfpgitidedtivsstgalslkkvpekmv
vigagvigvelgsvwqrlgadvtaveflghvggvgidmeisknfqrilqkqgfkfklntk
vtgatkksdgkidvsieaasggkaevitcdvllvcigrrpftknlgleelgieldprgri
pvntrfqtkipniyaigdvvagpmlahkaedegiicvegmaggavhidyncvpsviythp
evawvgkseeqlkeegieykvgkfpfaansraktnadtdgmvkilgqkstdrvlgahilg
pgagemvneaalaleygascediagvchahptlseafreanlaasfgksinf

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6i4sB (B:)
maswshpqfekgalevlfqgpgadqpidadvtvigsgpggyvaaikaaqlgfktvciekn
etlggtclnvgcipskallnnshyyhmahgkdfasrgiemsevrlnldkmmeqkstavka
ltggiahlfkqnkvvhvngygkitgknqvtatkadggtqvidtkniliatgsevtpfpgi
tidedtivsstgalslkkvpekmvvigagvigvelgsvwqrlgadvtaveflghvggvgi
dmeisknfqrilqkqgfkfklntkvtgatkksdgkidvsieaasggkaevitcdvllvci
grrpftknlgleelgieldprgripvntrfqtkipniyaigdvvagpmlahkaedegiic
vegmaggavhidyncvpsviythpevawvgkseeqlkeegieykvgkfpfaansraktna
dtdgmvkilgqkstdrvlgahilgpgagemvneaalaleygascediagvchahptlsea
freanlaasfgksinf

    Sequence, based on observed residues (ATOM records):
    >6i4sB (B:)
vlfqgpgadqpidadvtvigsgpggyvaaikaaqlgfktvcieknetlggtclnvgcips
kallnnshyyhmahgkdfasrgiemsevrlnldkmmeqkstavkaltggiahlfkqnkvv
hvngygkitgknqvtatkadggtqvidtkniliatgsevtpfpgitidedtivsstgals
lkkvpekmvvigagvigvelgsvwqrlgadvtaveflghvggvgidmeisknfqrilqkq
gfkfklntkvtgatkksdgkidvsieaasggkaevitcdvllvcigrrpftknlgleelg
ieldprgripvntrfqtkipniyaigdvvagpmlahkaedegiicvegmaggavhidync
vpsviythpevawvgkseeqlkeegieykvgkfpfaansraktnadtdgmvkilgqkstd
rvlgahilgpgagemvneaalaleygascediagvchahptlseafreanlaasfgksin
f