PDB entry 6i3z

View 6i3z on RCSB PDB site
Description: Fab fragment of an antibody selective for wild-type alpha-1-antitrypsin in complex with its antigen
Class: protein binding
Keywords: Antibody fragment, Antitrypsin binding, Diagnostic, Monoclonal, PROTEIN BINDING, selective, wild-type, Glu342, E342
Deposited on 2018-11-08, released 2019-11-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-05, with a file datestamp of 2020-07-31.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha-1-antitrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA1, AAT, PI, PRO0684, PRO2209
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: alpha-1-antitrypsin
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINA1, AAT, PI, PRO0684, PRO2209
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: FAB 2H2 heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6I3Z
    Domains in SCOPe 2.08: d6i3zh_
  • Chain 'L':
    Compound: FAB 2H2 light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6I3Z (0-End)
    Domains in SCOPe 2.08: d6i3zl1, d6i3zl2
  • Heterogens: NA, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6i3zH (H:)
evqleesggglvkpggslklscaasgfafsiydmswvrqtpekrlewvayissgggttyy
pdtvkgrftisrdnakntlylqmsslksedtaiyycarhagvhywgqgttltvssakttp
psvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytls
ssvtvpsstwpsetvtcnvahpasstkvdkkivprd

    Sequence, based on observed residues (ATOM records): (download) 
    >6i3zH (H:)
leesggglvkpggslklscaasgfafsiydmswvrqtpekrlewvayissgggttyypdt
vkgrftisrdnakntlylqmsslksedtaiyycarhagvhywgqgttltvssakttppsv
yplapvtlgclvkgyfpepvtvtwnsgslssvhtfpavlqsdlytlsssvtvpsstwpse
tvtcnvahpasstkvdkkivpr

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6i3zL (L:)
divmtqspssmyaslgervtitckasqdinsylswfqqkpgkspknliyranrlvdgvps
rfsgsgsgqdysltissleyedmgiyyclqydefpwtfgggtkleskradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >6i3zL (L:)
divmtqspssmyaslgervtitckasqdinsylswfqqkpgkspknliyranrlvdgvps
rfsgsgsgqdysltissleyedmgiyyclqydefpwtfgggtkleskradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgsegvlnswtdqdskdstysmsstltltk
deyerhnsytceathktstspivksfnr