PDB entry 6i3u

View 6i3u on RCSB PDB site
Description: optimization of potent and selective atm inhibitors suitable for a proof-of-concept study in huntington's disease models
Deposited on 2018-11-07, released 2019-03-20
The last revision was dated 2019-04-10, with a file datestamp of 2019-04-05.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 3-kinase catalytic subunit type 3
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3C3, VPS34
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NEB9
      • engineered mutation (346)
      • engineered mutation (350)
      • engineered mutation (368)
      • engineered mutation (416)
      • engineered mutation (418)
      • insertion (421)
  • Heterogens: H2E, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6i3uA (A:)
smskhhklarslrsgpsdhdlkpnaatrdqlniivsypptkqltyeeqdlvwkfryyltn
qekaltkflkcvnwdlpqeakqalellgkwkpmdvedslellsshytnptvrryavarlr
qaddedllmyllqlvqalkyenfddikngleptkkdsqssvsenvsnsginsaeidssqi
itsplpsvsspppasktkevpdgenleqdlctflisracknstlanylywyvivecedqd
tqqrdpkthemylnvmrrfsqallkgdksvrvmrsllaaqqtfvdrlvhlmkavqresgn
rkkknerlqallgdnekmnlsdveliplplepqvkirgiipetatlaksanmpaqlffkt
edggkypvlfkhgddlrqdqlilqiislmdkllrkenldlkltpykvlatstkhgflqwi
qgsvpvaevldtegsiqnffrkyapsengpngisaevmdtyvkscagycvityilgvgdr
hldnllltktgklfhidfgyilgrdpkplpppmklnkemvegmggtqseqyqefrkqcyt
aflhlrrysnlilnlfslmvdanipdialepdktvkkvqdkfrldlsdeeavhymqslid
esvhalfaavveqih

    Sequence, based on observed residues (ATOM records):
    >6i3uA (A:)
klarslrsgpsdhdlkpnaatrdqlniivsypptkqltyeeqdlvwkfryyltnqekalt
kflkcvnwdlpqeakqalellgkwkpmdvedslellsshytnptvrryavarlrqadded
llmyllqlvqalkyenfddiknglidssqiitsplpeqdlctflisracknstlanylyw
yvivecedqdtqqrdpkthemylnvmrrfsqallkgdksvrvmrsllaaqqtfvdrlvhl
mkavqresgnrkkknerlqallgdnekmnlsdveliplplepqvkirgiipetatlaksa
nmpaqlffktedggkypvlfkhgddlrqdqlilqiislmdkllrkenldlkltpykvlat
stkhgflqwiqgsvpvaevldtegsiqnffrkyapsengpngisaevmdtyvkscagycv
ityilgvgdrhldnllltktgklfhidfgyilgrdpkplpppmklnkemvegmggtqseq
yqefrkqcytaflhlrrysnlilnlfslmvdanipdialepdktvkkvqdkfrldlsdee
avhymqslidesvhalf