PDB entry 6i2y

View 6i2y on RCSB PDB site
Description: Human STK10 bound to Foretinib
Class: transferase
Keywords: kinase, inhibitor, complex, LOK, TRANSFERASE, foretinib
Deposited on 2018-11-02, released 2018-12-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-12-12, with a file datestamp of 2018-12-07.
Experiment type: XRAY
Resolution: 2.56 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: STK10, LOK
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94804 (Start-301)
      • conflict (256)
    Domains in SCOPe 2.08: d6i2ya_
  • Chain 'B':
    Compound: serine/threonine-protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: STK10, LOK
    Database cross-references and differences (RAF-indexed):
    • Uniprot O94804 (Start-301)
      • conflict (256)
    Domains in SCOPe 2.08: d6i2yb_
  • Heterogens: 88Z

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6i2yA (A:)
smrksreyehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeel
edyiveieilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiq
vvcrqmlealnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqkrdsfigt
pywmapevvmcetmkdtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpp
tlltpskwsvefrdflaialdknpetrpsaaqllehpfvssitsnkalrelvaeakaevm
ee

    Sequence, based on observed residues (ATOM records): (download) 
    >6i2yA (A:)
ehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeeledyiveie
ilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiqvvcrqmle
alnflhskriihrdlkagnvlmtlegdirladfgvsaknigtpywmapevvmcepydyka
diwslgitliemaqiepphhelnpmrvllkiaksdpptlltpskwsvefrdflaialdkn
petrpsaaqllehpfvssitsnkalrelvaeakaevmee

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6i2yB (B:)
smrksreyehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvietkseeel
edyiveieilatcdhpyivkllgayyhdgklwimiefcpggavdaimleldrgltepqiq
vvcrqmlealnflhskriihrdlkagnvlmtlegdirladfgvsaknlktlqkrdsfigt
pywmapevvmcetmkdtpydykadiwslgitliemaqiepphhelnpmrvllkiaksdpp
tlltpskwsvefrdflaialdknpetrpsaaqllehpfvssitsnkalrelvaeakaevm
ee

    Sequence, based on observed residues (ATOM records): (download) 
    >6i2yB (B:)
ehvrrdldpnevweivgelgdgafgkvykaknketgalaaakvieteeeledyiveieil
atcdhpyivkllgayyhdglwimiefcpggavdaimleldrgltepqiqvvcrqmlealn
flhskriihrdlkagnvlmtlegdirladfgvsaknigtpywmapevvmcetpydykadi
wslgitliemaqiepphhelnpmrvllkiaksdpptlltpskwsvefrdflaialdknpe
trpsaaqllehpfvssitsnkalrelvaeakaevmee