PDB entry 6i2p

View 6i2p on RCSB PDB site
Description: Crystal structure of the Mycobacterium tuberculosis PknB kinase domain (L33E mutant) in complex with its substrate GarA
Class: signaling protein
Keywords: kinase, FHA-domain protein, SIGNALING PROTEIN
Deposited on 2018-11-01, released 2019-05-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-22, with a file datestamp of 2019-05-17.
Experiment type: XRAY
Resolution: 2.37 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase pknb
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: pknB, Rv0014c, MTCY10H4.14c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WI81 (1-End)
      • engineered mutation (33)
    Domains in SCOPe 2.08: d6i2pa_
  • Chain 'B':
    Compound: serine/threonine-protein kinase pknb
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: pknB, Rv0014c, MTCY10H4.14c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WI81
      • engineered mutation (33)
    Domains in SCOPe 2.08: d6i2pb_
  • Chain 'C':
    Compound: unk-unk-unk-unk-unk
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 6I2P (0-4)
  • Chain 'D':
    Compound: Glycogen accumulation regulator GarA
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: garA, Rv1827, MTCY1A11.16c
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Glycogen accumulation regulator GarA
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: garA, Rv1827, MTCY1A11.16c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6i2pe_
  • Heterogens: ACP, MG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6i2pA (A:)
gmttpshlsdryelgeilgfggmsevhlardlrehrdvavkvlradlardpsfylrfrre
aqnaaalnhpaivavydtgeaetpagplpyivmeyvdgvtlrdivhtegpmtpkraievi
adacqalnfshqngiihrdvkpanimisatnavkvmdfgiaraiadsgnsvtqtaavigt
aqylspeqargdsvdarsdvyslgcvlyevltgeppftgdspvsvayqhvredpippsar
heglsadldavvlkalaknpenryqtaaemradlvrvhng

    Sequence, based on observed residues (ATOM records): (download) 
    >6i2pA (A:)
mttpshlsdryelgeilgfggmsevhlardlrehrdvavkvlradlardpsfylrfrrea
qnaaalnhpaivavydtgeaetpagplpyivmeyvdgvtlrdivhtegpmtpkraievia
dacqalnfshqngiihrdvkpanimisatnavkvmdfgiarnsvtqtaavigtaqylspe
qargdsvdarsdvyslgcvlyevltgeppftgdspvsvayqhvredpippsarheglsad
ldavvlkalaknpenryqtaaemradlvrvhn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6i2pB (B:)
gmttpshlsdryelgeilgfggmsevhlardlrehrdvavkvlradlardpsfylrfrre
aqnaaalnhpaivavydtgeaetpagplpyivmeyvdgvtlrdivhtegpmtpkraievi
adacqalnfshqngiihrdvkpanimisatnavkvmdfgiaraiadsgnsvtqtaavigt
aqylspeqargdsvdarsdvyslgcvlyevltgeppftgdspvsvayqhvredpippsar
heglsadldavvlkalaknpenryqtaaemradlvrvhng

    Sequence, based on observed residues (ATOM records): (download) 
    >6i2pB (B:)
ttpshlsdryelgeilgfggmsevhlardlrehrdvavkvlradlardpsfylrfrreaq
naaalnhpaivavydtgeaetpagplpyivmeyvdgvtlrdivhtegpmtpkraieviad
acqalnfshqngiihrdvkpanimisatnavkvmdfgiansvtqtaataqylspeqargd
svdarsdvyslgcvlyevltgeppftgdspvsvayqhvredpippsarheglsadldavv
lkalaknpenryqtaaemradlvrvh

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6i2pE (E:)
gmtdmnpdiekdqtsdevtvettsvfradflseldapaqagtesavsgveglppgsallv
vkrgpnagsrflldqaitsagrhpdsdiflddvtvsrrhaefrlennefnvvdvgslngt
yvnrepvdsavlangdevqigkfrlvfltgpkqgeddgstggp

    Sequence, based on observed residues (ATOM records): (download) 
    >6i2pE (E:)
gveglppgsallvvkrgpnagsrflldqaitsagrhpdsdiflddvtvsrrhaefrlenn
efnvvdvgslngtyvnrepvdsavlangdevqigkfrlvfltgp