PDB entry 6hzv

View 6hzv on RCSB PDB site
Description: human jak3 in complex with lasw959 protein in complex with ligand
Deposited on 2018-10-24, released 2019-10-23
The last revision was dated 2019-11-06, with a file datestamp of 2019-11-01.
Experiment type: XRAY
Resolution: 2.46 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK3
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (0-End)
      • conflict (233)
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK3
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (0-284)
      • conflict (233)
  • Chain 'C':
    Compound: Tyrosine-protein kinase JAK3
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (0-End)
      • conflict (233)
  • Chain 'D':
    Compound: Tyrosine-protein kinase JAK3
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P52333 (0-End)
      • conflict (233)
  • Heterogens: GYW, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hzvA (A:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqic
kgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwy
apeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgcerdvpalsrllell
eegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlw

    Sequence, based on observed residues (ATOM records):
    >6hzvA (A:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqgpdqqrdfqreiqilk
alhsdfivkyrgvsyqslrlvmeylpsgclrdflqrhrarldasrlllyssqickgmeyl
gsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrpifwyapeslsdnifs
rqsdvwsfgvvlyelftycdkscspsaeflrmpalsrllelleegqrlpappacpaevhe
lmklcwapspqdrpsfsalgpqldml

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hzvB (B:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqic
kgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwy
apeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgcerdvpalsrllell
eegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlw

    Sequence, based on observed residues (ATOM records):
    >6hzvB (B:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqgpdqqrdfqreiqilk
alhsdfivkyrgvsyqslrlvmeylpsgclrdflqrhrarldasrlllyssqickgmeyl
gsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvpifwyapeslsdnifsr
qsdvwsfgvvlyelftycdkscspsaeflrmrdvpalsrllelleegqrlpappacpaev
helmklcwapspqdrpsfsalgpqldmlw

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6hzvC (C:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqic
kgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwy
apeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgcerdvpalsrllell
eegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlw

    Sequence, based on observed residues (ATOM records):
    >6hzvC (C:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqgpdqqrdfqreiqilk
alhsdfivkyrgvsyslrlvmeylpsgclrdflqrhrarldasrlllyssqickgmeylg
srrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvspifwyapeslsdnifsr
qsdvwsfgvvlyelftycdkscspsaeflrmpalsrllelleegqrlpappacpaevhel
mklcwapspqdrpsfsalgpqldml

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6hzvD (D:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqhsgpdqqrdfqreiqi
lkalhsdfivkyrgvsygpgrqslrlvmeylpsgclrdflqrhrarldasrlllyssqic
kgmeylgsrrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvrepgqspifwy
apeslsdnifsrqsdvwsfgvvlyelftycdkscspsaeflrmmgcerdvpalsrllell
eegqrlpappacpaevhelmklcwapspqdrpsfsalgpqldmlw

    Sequence, based on observed residues (ATOM records):
    >6hzvD (D:)
tifeerhlkyisqlgkgnfgsvelcrydplgdntgalvavkqlqgpdqqrdfqreiqilk
alhsdfivkyrgvsyslrlvmeylpsgclrdflqrhrarldasrlllyssqickgmeylg
srrcvhrdlaarnilveseahvkiadfglakllpldkdyyvvspifwyapeslsdnifsr
qsdvwsfgvvlyelftycdkscspsaelsrllelleegqrlpappacpaevhelmklcwa
pspqdrpsfsalgpqldml