PDB entry 6hzm

View 6hzm on RCSB PDB site
Description: cryo-em structure of the abcg2 e211q mutant bound to atp and magnesium (alternative placement of magnesium into the cryo-em density)
Deposited on 2018-10-23, released 2018-11-14
The last revision was dated 2019-12-18, with a file datestamp of 2019-12-13.
Experiment type: EM
Resolution: 3.09 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ATP-binding cassette sub-family G member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCG2, ABCP, BCRP, BCRP1, MXR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UNQ0
      • engineered mutation (210)
  • Chain 'B':
    Compound: ATP-binding cassette sub-family G member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ABCG2, ABCP, BCRP, BCRP1, MXR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UNQ0
      • engineered mutation (210)
  • Heterogens: ATP, MG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6hzmA (A:)
msssnvevfipvsqgntngfpatasndlkaftegavlsfhnicyrvklksgflpcrkpve
keilsningimkpglnailgptgggksslldvlaarkdpsglsgdvlingaprpanfkcn
sgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqelgldkvadskvgt
qfirgvsggerkrtsigmelitdpsilfldqpttgldsstanavllllkrmskqgrtiif
sihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceaynnpadffldiing
dstavalnreedfkateiiepskqdkplieklaeiyvnssfyketkaelhqlsggekkkk
itvfkeisyttsfchqlrwvskrsfknllgnpqasiaqiivtvvlglvigaiyfglknds
tgiqnragvlfflttnqcfssvsavelfvvekklfiheyisgyyrvssyflgkllsdllp
mrmlpsiiftcivyfmlglkpkadaffvmmftlmmvaysassmalaiaagqsvvsvatll
mticfvfmmifsgllvnlttiaswlswlqyfsiprygftalqhneflgqnfcpglnatgn
npcnyatctgeeylvkqgidlspwglwknhvalacmivifltiaylkllflkkys

    Sequence, based on observed residues (ATOM records):
    >6hzmA (A:)
gavlsfhnicyrvklpvekeilsningimkpglnailgptgggksslldvlaarkdpsgl
sgdvlingaprpanfkcnsgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerin
rviqelgldkvadskvgtqfirgvsggerkrtsigmelitdpsilfldqpttgldsstan
avllllkrmskqgrtiifsihqprysifklfdsltllasgrlmfhgpaqealgyfesagy
hceaynnpadffldiingdstavalnrekplieklaeiyvnssfyketkaelhqlsisyt
tsfchqlrwvskrsfknllgnpqasiaqiivtvvlglvigaiyfglkndstgiqnragvl
fflttnqcfssvsavelfvvekklfiheyisgyyrvssyflgkllsdllpmrmlpsiift
civyfmlglkpkadaffvmmftlmmvaysassmalaiaagqsvvsvatllmticfvfmmi
fsgllvnlttiaswlswlqyfsiprygftalqhneflgqnfcpglnatgnnpcnyatctg
eeylvkqgidlspwglwknhvalacmivifltiaylkllflkky

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6hzmB (B:)
msssnvevfipvsqgntngfpatasndlkaftegavlsfhnicyrvklksgflpcrkpve
keilsningimkpglnailgptgggksslldvlaarkdpsglsgdvlingaprpanfkcn
sgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerinrviqelgldkvadskvgt
qfirgvsggerkrtsigmelitdpsilfldqpttgldsstanavllllkrmskqgrtiif
sihqprysifklfdsltllasgrlmfhgpaqealgyfesagyhceaynnpadffldiing
dstavalnreedfkateiiepskqdkplieklaeiyvnssfyketkaelhqlsggekkkk
itvfkeisyttsfchqlrwvskrsfknllgnpqasiaqiivtvvlglvigaiyfglknds
tgiqnragvlfflttnqcfssvsavelfvvekklfiheyisgyyrvssyflgkllsdllp
mrmlpsiiftcivyfmlglkpkadaffvmmftlmmvaysassmalaiaagqsvvsvatll
mticfvfmmifsgllvnlttiaswlswlqyfsiprygftalqhneflgqnfcpglnatgn
npcnyatctgeeylvkqgidlspwglwknhvalacmivifltiaylkllflkkys

    Sequence, based on observed residues (ATOM records):
    >6hzmB (B:)
gavlsfhnicyrvklpvekeilsningimkpglnailgptgggksslldvlaarkdpsgl
sgdvlingaprpanfkcnsgyvvqddvvmgtltvrenlqfsaalrlattmtnheknerin
rviqelgldkvadskvgtqfirgvsggerkrtsigmelitdpsilfldqpttgldsstan
avllllkrmskqgrtiifsihqprysifklfdsltllasgrlmfhgpaqealgyfesagy
hceaynnpadffldiingdstavalnrekplieklaeiyvnssfyketkaelhqlsisyt
tsfchqlrwvskrsfknllgnpqasiaqiivtvvlglvigaiyfglkndstgiqnragvl
fflttnqcfssvsavelfvvekklfiheyisgyyrvssyflgkllsdllpmrmlpsiift
civyfmlglkpkadaffvmmftlmmvaysassmalaiaagqsvvsvatllmticfvfmmi
fsgllvnlttiaswlswlqyfsiprygftalqhneflgqnfcpglnatgnnpcnyatctg
eeylvkqgidlspwglwknhvalacmivifltiaylkllflkky